| abstract |
NEW MATERIAL:The compound of formulaI(R is H, lower alkyl, or cycloalkyl; A is lower alkylene; the dotted line represents single or double bond) and its salt. n EXAMPLE: 5-[(2-Cyclohexyl-imidazol-1-yl)]-3,4-dihydrocarbostyril. n USE: Preventive for thrombosis, and remedy or preventive for ischemic cardiopathy such as hypertension, stenocardia, cardiac infaction, etc., and cerebral diseases such as cerebral apoplexy, transient ischemic attack, migraine, etc. n PROCESS: The compound of formulaIcan be prepared e.g. by reacting the compound of formula II[X is halogen, -OSO 2 R 1 (R 1 is lower alkyl or aryl), or - + N(R 2 ) 3 (R 2 is lower alkyl)]with the compound of formula III preferably in the presence of a basic compound (e.g. NaOH) at room temperature W100°C. n COPYRIGHT: (C)1982,JPO&Japio |