| abstract |
PURPOSE: To obtain a platelet adhesion suppresser useful for arteriosclerosis, etc., containing a specific carbostyril derivative or a salt thereof as an active ingredient. n CONSTITUTION: A platelet adhesion suppresser containing a compound shown by formula 1 [R is (substituted) unsaturated heterocyclic residue containing 1W4 hetero atoms selected from N, O, S, etc.; R 1 is H, lower alkyl or phenyl lower alkyl; R 2 is H, halogen, etc.; Z is O, S, group -NH-, etc.; A is lower alkylene; X is O, S group -SO-, etc.; n is 0 or 1; carbon-carbon bond of carbostyril skeleton at 3- and 4-positions is single or double bond] or a salt thereof as an active ingredient. The compound shown formula 1 is obtained by various method and a compound shown by formula 1a is obtained by reacting a compound shown by formula 2 (Za is O, S, etc.) with a compound shown by formula 3 (X 1 is halogen, etc.) in the presence of NaOH, etc., according to the reaction formula. n COPYRIGHT: (C)1988,JPO&Japio |