http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101822761-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4709 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G02B2207-114 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-6458 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N21-64 |
| filingDate | 2016-12-21^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-01-29^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2018-01-29^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101822761-B1 |
| titleOfInvention | New compounds or pharmaceutically acceptable salt thereof selective for amyloid-β plaque and method for imaging amyloid-β plaque in vivo using the same |
| abstract | The present invention relates to a novel compound which is selective for beta amyloid plaques or a pharmaceutically acceptable salt thereof and a method for imaging beta amyloid plaques using the same, more specifically, And a method for synthesizing a novel compound or a pharmaceutically acceptable salt thereof, which can be used therefor, in a high-resolution three-dimensional imaging through a low-energy-source two-photon microscope. A novel compound, or a pharmaceutically acceptable salt thereof, selective to beta amyloid plaques according to the present invention releases strong two-photon fluorescence and is selectively stained with amyloid. In addition, the compound or its pharmaceutically acceptable salt has a property of passing through the blood brain barrier of a rat efficiently because of its low molecular weight and electrically neutral nature. Based on these properties, amyloid deposition in the brain of transgenic mice can be imaged into a high-resolution three-dimensional image using a two-photon microscope. |
| priorityDate | 2016-03-23^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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