| abstract |
The present invention provides a bisamidine derivative containing bis(amidino) indole benzene, a preparation method and use thereof, and an antibacterial drug combination. The bisamidine derivative has a structure of the following formula [1], wherein R 1 and R 2 are independently selected from substituted or unsubstituted C 1-12 linear alkyl, C 3-12 branched alkyl or C 3-12 cyclic alkyl; alternatively, R 1 and R 2 and N connected thereto are composed of a substituted or unsubstituted 3- to 6-membered ring; and R 3 is independently selected from hydrogen, halogen, lower halogenated alkyl, lower alkoxy, amino or lower substituted amino. The bisamidine derivative containing bis(amidino) indole benzene provided by the present invention and a medicinal salt thereof have the activity of anti-drug-resistance bacteria, in particular having a strong activity of anti-drug-resistance gram positive and negative bacteria. |