http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004043949-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-06 |
| filingDate | 2002-08-30^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1a13eea4284d7350669c13678741cf7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3de7288b01800f451e794109c6d06f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a3e386dad3f3728507248d5e798ee27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1248b7fc8bc750ce44ad633a425859ce |
| publicationDate | 2004-03-04^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2004043949-A1 |
| titleOfInvention | Therapeutic system targeting pathogen proteases and uses thereof |
| abstract | The invention provides anti-pathogen polypeptide and polynucleotide compositions, and methods of use. In general, the composition of the invention provide a modified pro-polypeptide comprising a pro-domain, a pathogen protease cleavage site, and a cytotoxic domain which can be activated by cleavage of the pro-polypeptide by a protease of an intracellular pathogen. The invention further provides nucleic acids encoding the subject polypeptides, and vectors and host cells comprising the subject nucleic acids. Cleavage of the pro-polypeptide by the pathogen protease results in activation of the cytotoxic domain, and decreases the viability of the pathogen-infected host cell. Methods for using the subject nucleic acids and polypeptides to reduce the viability of a pathogen-infected cell, and for reducing the pathogen load of a subject infected with a pathogen are provided. The invention further provides kits for carrying out the subject methods. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9212355-B2 |
| priorityDate | 2002-08-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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