| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_faa39c669d799fd78c788d419308c61c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fd088b6eaceefa094ab9243c7b8ff50 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-11 |
| filingDate |
2009-02-17^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0edd1fb8f9e203c9dc8192fbaa2d9a8f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67ec63002ab58f34e9f09162c106d9a6 |
| publicationDate |
2009-09-17^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2009234096-A1 |
| titleOfInvention |
Influenza inhibiting compositions and methods |
| abstract |
The present invention provides compositions useful for treating or preventing influenza infections. The composition comprises an isolated polypeptide including a sequence of at least 8 contiguous amino acid residues of the fusion initiation region (FIR) of an influenza hemagglutinin 2 protein or a peptide analog of the sequence. The FIR is a segment of the full length hemagglutinin 2 protein which is bounded by an amino-terminal region within the amino-terminal alpha-helix thereof and a carboxy terminus within the carboxy-terminal alpha-helix thereof, with a cysteine loop therebetween. The amino-terminal region of the FIR comprises a portion of the final 10 to 20 amino acid residues of the amino-terminal alpha-helix of the hemagglutinin 2 protein, and includes 3 or 4 hydrophobic amino acid residues, a positively-charged amino acid residue, a negatively-charged amino acid residue, and an aromatic amino acid residue. The carboxy terminus of the FIR is the carboxy terminus of the first peptide sequence of the hemagglutinin 2 protein beyond the amino terminal helix, which exhibits a positive Wimley-White interfacial hydrophobicity. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014271650-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8877200-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014160171-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11230593-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10537634-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10513553-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2014244071-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EA-030004-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9649375-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10137194-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9969794-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9096657-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10800835-B2 |
| priorityDate |
2006-05-03^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |