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filingDate 2017-05-10^^<http://www.w3.org/2001/XMLSchema#date>
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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81ab3a945b583279f3d065e0dd98aa7e
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publicationDate 2018-11-27^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-10137194-B2
titleOfInvention Immunogenic peptide conjugate and method for inducing an anti-influenza therapeutic antibody response therewith
abstract Immunogenic influenza hemagglutinin-derived peptide conjugates described herein induce a specific therapeutic antibody response against influenza virus. The immunogenic peptide conjugates comprise a segment from the fusion initiation region (FIR) domain of an influenza hemagglutinin protein conjugated to an immunogenic carrier protein, such asbovine serum albumin (BSA), an influenza hemagglutinin (HA) protein (i.e., full length HA), and the like. The immunogenic peptide conjugates described herein can be utilized to treat or prevent influenza infection and to prepare influenza-specific therapeutic antibodies that interfere with influenza virus-host cell membrane fusion. The peptide conjugates can be formulated in pharmaceutical compositions useful for broad spectrum treatment or prevention of influenza infections.
priorityDate 2013-03-14^^<http://www.w3.org/2001/XMLSchema#date>
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http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID213
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0C781
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP0C782
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http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID85302
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9Q0U7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP03484
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP03481
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ07578
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ09106
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http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID90437872
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ09104
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ07577
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ67214
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ07582
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226471664
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP03473
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ07583
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226471665
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID10571

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