| abstract |
A cell culture reactor is provided for the growth of cells in vitro which employs elongate, selectively permeable hollow fibers arranged in a shallow layer configuration as a matrix for cell attachment on the outer surface of the fibers, and aeration of the cells by passage through the interior of said fibers and permeation of the membrane cell. The flow path of the culture media is directed by distributor plate means substantially uniformly through the fiber layer and substantially transverse to the plane of the elongate axes of the fibers. |