| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c81d97576dbeeb2b3e24fb19792da2e1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S366-03 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-128
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6821 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-86
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-12 |
| filingDate |
1992-07-15^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
1994-04-19^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84422ff70f8279a366c9353ec2f680f1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_26f370ffbaa1f829c84b4229f9818879
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f5cf97dcd580faaad6aee4855ce693a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_183d45ba66a18051d0c487dd9bd0cab0 |
| publicationDate |
1994-04-19^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-5304497-A |
| titleOfInvention |
Method of forming N-protected amino acid thiohydantoins |
| abstract |
A method of forming a thiohydantoin from an N-protected amino acid. The method employs a uronium or phosphonium compound to activate the terminal carboxyl group of the amino acid and a thiocyanate reagent to cyclize the activated amino acid to the thio-hydantoin. The thiohydantoin can be cleaved from its N-protecting group, for use in C-terminal peptide sequencing. Particularly preferred uronium compounds include salts of 2-chlorouronium. Preferred thiocyanate reagents include trimethylsilyl isothiocyanate and crown ether adducts of metallothiocyanates, such as the 18-crown-6 adduct of KSCN. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9607916-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0823056-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-0823056-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5602207-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5468843-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5665603-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2336783-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5717075-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6299881-B1 |
| priorityDate |
1991-10-15^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |