| abstract |
PCT No. PCT/GB95/00042 Sec. 371 Date Jul. 11, 1996 Sec. 102(e) Date Jul. 11, 1996 PCT Filed Jan. 11, 1995 PCT Pub. No. WO95/19187 PCT Pub. Date Jul. 20, 1995A conjugate comprises a linear or cyclic synthetic peptide of 3-50 amino acids linked via one of its carboxyl groups and optionally via a linking group, to a polydentate metal chelating group, with the result that endo- or exo-peptidase metabolism of the peptide is substantially inhibited, with the provisos that: a) the peptide chain contains a biological targeting sequence which is biologically active; b) when the spacer is absent the metal chelating group does not comprise solely peptide moieties; c) the metal chelating group does not contain thiol donors. A complex of the conjugate with a metal atom chelated by the metal chelating group is useful in medicine. |