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filingDate 1997-12-12^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 1998-09-08^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce30bb1e4b06f37fbfc2ce2b2f71b8d1
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publicationDate 1998-09-08^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-5804157-A
titleOfInvention Peptide compositions and method of radiolabeling
abstract This invention relates to radiolabeled peptide compositions for radiopharmaceutical use and, more specifically, to radiolabeled peptides for diagnostic or therapeutic use having an unmodified carboxy terminal amino acid. The radiopharmaceutical composition may be used for targeting a selected biological site. The radiolabeled peptide is characterized by having its carboxy terminal amino acid in its carboxylic acid form and the peptide is coupled to a diagnostic or therapeutic radionuclide by a chelating agent. The radiopharmaceutical composition preferably comprises a radiolabeled peptide selected from the group consisting of somatostatin, an analog of somatostatin, a derivative of somatostatin and peptides capable of binding to the somatostatin receptor, where the peptide is coupled to a diagnostic or therapeutic radionuclide by a chelating agent has its carboxy terminal amino acid in its carboxylic acid form.
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priorityDate 1995-06-07^^<http://www.w3.org/2001/XMLSchema#date>
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