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filingDate 1997-11-24^^<http://www.w3.org/2001/XMLSchema#date>
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inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a927b3a7ba9e23ccf06c0fd58778b6b4
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publicationDate 2001-01-09^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-6171817-B1
titleOfInvention Heterologous polypeptides expressed in filamentous fungi, process for making same, and vectors for making same
abstract Novel vectors are disclosed for expressing and secreting heterologous polypeptides from filamentous fungi. Such vectors are used in novel processes to express and secrete such heterologous polypeptides. The vectors used for transforming a filamentous fungus to express and secrete a heterologous polypeptide include a DNA sequence encoding a heterologous polypeptide and a DNA sequence encoding a signal sequence which is functional in a secretory system in a given filamentous fungus and which is operably linked to the sequence encoding the heterologous polypeptide. Such signal sequences may be the signal sequence normally associated with the heterologous polypeptides or may be derived from other sources. The vector may also contain DNA sequences encoding a promoter sequence which is functionally recognized by the filamentous fungus and which is operably linked to the DNA sequence encoding the signal sequence. Preferably functional polyadenylation sequences are operably linked to the 3' terminus of the DNA sequence encoding the heterologous polypeptides. Each of the above described vectors are used in novel processes to transform a filamentous fungus wherein the DNA sequences encoding the signal sequence and heterologous polypeptide are expressed. The thus synthesized polypeptide is thereafter secreted from the filamentous fungus.
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB3R6U7
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC5CQB2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0W4B8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7I9Y9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA1SJF3
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419593497
http://rdf.ncbi.nlm.nih.gov/pubchem/anatomy/ANATOMYID992
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9VTC3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8FF31
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9PJ53
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC5BP61
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB8GXJ5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB9J7M8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4W1D9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7I534
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9PH97
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0U9X3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP57903
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO60109
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7M0P9
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ0TT93
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7JJX0
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID403426
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO60087
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC5BEW3
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7HZG2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP57479
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB0T410
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID8972
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8ES39
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9WYI4
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC5A786
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426383164
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID396985
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8AXZ6
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID994
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA3M508
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6T4L2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC4ZYF5
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226398728
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6T2B3
http://rdf.ncbi.nlm.nih.gov/pubchem/taxonomy/TAXID5547
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226398727
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB2I656
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP54517
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO94127
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID451780255
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB1JKF8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7L5P5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA8AQF2
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA6S694
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ634Y5
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7KFE6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP06869
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ12UJ8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9V1H8
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB1HQC3
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426383620
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA4VV36
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB7N497
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ4JC71
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID228304246
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCB6JHG1
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID6305
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ12J15
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCO93864
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID936617
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCC5D8Q3
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1255525
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA7I8M6
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCA9BS60
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9YEK1
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9RW91

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