abstract |
Compounds are provided which have the structure n n nwherein Q is C or N; R 2a , R 2b , R 2c , X 1 to X 7 , R 1 , R 2 , R 3 , R 3a , R 4 , A, Y, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents. The present invention further provides a method for treating obesity and dyslipidemia in mammals including humans through simultaneous inhibition of peroxisome proliferator activated receptor-γ (PPARγ) and stimulation of peroxisome proliferator activated receptor-α (PPARα). |