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filingDate 2005-05-20^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2010-12-07^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7846389-B2
titleOfInvention High throughput screen
abstract The present invention relates to a structure comprising a biological membrane and a porous or perforated substrate, a biological membrane, a substrate, a high throughput screen, methods for production of the structure membrane and substrate, and a method for screening a large number of test compounds in a short period. More particularly it relates to a structure comprising a biological membrane adhered to a porous or perforated substrate, a biological membrane capable of adhering with high resistance seals to a substrate such as perforated glass and the ability to form sheets having predominantly an ion channel or transporter of interest, a high throughput screen for determining the effect of test compounds on inn channel or transporter activity, methods for manufacture of the structure, membrane and substrate, and a method for monitoring ion channel or transporter activity in a membrane.
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