http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8222204-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_faa39c669d799fd78c788d419308c61c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60867eeac051ca001adebb32120e016b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fd088b6eaceefa094ab9243c7b8ff50 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-04 |
| filingDate | 2009-02-17^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-07-17^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de677f1a44feebe9a0f481aa35c7b642 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc80b176d6121e01f387c7b2bd29edf3 |
| publicationDate | 2012-07-17^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8222204-B2 |
| titleOfInvention | Influenza inhibiting compositions and methods |
| abstract | The present invention provides compositions useful for treating or preventing influenza infections. The composition comprises an isolated polypeptide including a sequence of at least 8 contiguous amino acid residues of the fusion initiation region (FIR) of an influenza hemagglutinin 2 protein or a peptide analog of the sequence. The FIR is a segment of the full length hemagglutinin 2 protein which is bounded by an amino-terminal region within the amino-terminal alpha-helix thereof and a carboxy terminus within the carboxy-terminal alpha-helix thereof, with a cysteine loop therebetween. The amino-terminal region of the FIR comprises a portion of the final 10 to 20 amino acid residues of the amino-terminal alpha-helix of the hemagglutinin 2 protein, and includes 3 or 4 hydrophobic amino acid residues, a positively-charged amino acid residue, a negatively-charged amino acid residue, and an aromatic amino acid residue. The carboxy terminus of the FIR is the carboxy terminus of the first peptide sequence of the hemagglutinin 2 protein beyond the amino terminal helix, which exhibits a positive Wimley-White interfacial hydrophobicity. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10137194-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014271650-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9649375-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10537634-B2 |
| priorityDate | 2006-05-03^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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