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filingDate 2009-09-30^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-07-07^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_58633c917f30a6bbbdb35c3172ef4521
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publicationDate 2015-07-07^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9072791-B2
titleOfInvention Photostabilized pharmaceutical compositions
abstract A crosslinking reaction and a reaction for reducing molecular weight that take place in a hyaluronic acid-methotrexate conjugate upon irradiation with light are suppressed to improve the photostability of the conjugate. Specifically, a substance having a quenching effect and/or a radical scaveng effect is added to a pharmaceutical composition containing the hyaluronic acid-methotrexate conjugate.
priorityDate 2008-09-30^^<http://www.w3.org/2001/XMLSchema#date>
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http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226712781
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID453528129
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID419582727
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226493668
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226396167
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID456988458
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226395985
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226396570
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID16760658
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID455364086
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID23663392
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID415725237
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID426103861
http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID226428497
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID7456

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