http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9849241-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_502bfc0709ea9ed74ef0d69764f0be2c |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2230-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2230-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M2205-35 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M5-172 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M5-1723 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F19-3468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H20-17 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16H20-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-172 |
| filingDate | 2014-02-24^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-12-26^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad1ff3aa9c047a472621d78101b1cd66 |
| publicationDate | 2017-12-26^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9849241-B2 |
| titleOfInvention | Method of operating a control device for controlling an infusion device |
| abstract | Method of operating a control device for controlling an infusion device A method of operating a control device ( 2 ) for controlling an infusion device ( 33 ) for administering a drug to a patient (P) comprises the steps of: providing a model (p) to predict a time-dependent drug concentration (Cplasma, Clung, Cbrain) in multiple compartments (A 1 -A 5 ) of a patient (P); setting a target concentration value (CTbrain) to be achieved in at least one of the compartments (A 1 -A 5 ) of the patient (P); determining a drug dosage (D 1 ) to be administered to a first compartment (A 1 ) of the multiple compartments (A 1 -A 5 ) of the patient (P) using the model (p) such that the difference between the target concentration value (CTbrain) and a predicted steady-state drug concentration (Cplasma, Clung, Cbrain) in the at least one of the compartments (A 1 -A 5 ) is smaller than a pre-defined threshold value (Ub-rain); providing a control signal (S 1 ) indicative of the drug dosage (D 1 ) to an infusion device ( 33 ) for administering the drug dosage (D 1 ) to the patient (P); obtaining a measurement value (M 1 , M 2 ) indicating a measured drug concentration in a second compartment (A 2 , A 3 ) of the multiple compartments (A 1 -A 5 ) at a measurement time (t 1 , t 2 ); adjusting the model (p) such that the model (p) predicts a drug concentration (Clung, Cbrain) in the second compartment (A 2 , A 3 ) at the measurement time (t 1 , t 2 ) which at least approximately matches the measured drug concentration in the second compartment (A 2 , A 3 ); and determining a new drug dosage (D 2 , D 3 ) to be administered into the first compartment (A 1 ) of the patient (P) using the model (p) such that the difference between the target concentration value (CT-brain) and a predicted steady-state drug concentration (Cplasma, Clung, Cbrain) in the at least one of the compartments (A 1 , A 2 , A 3 ) is smaller than the predefined threshold value (Ubrain). In this way a method is provided which allows for an improved (personalized and predictive) control of a drug administration procedure, in particular when administering an anaesthetic drug such as Propofol and/or an analgesic drug such as Remifentanil within a procedure. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021322674-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11266780-B2 |
| priorityDate | 2013-04-24^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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