| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1aa278a5a86d998f098b00d35ab452e1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_555f9876aaa298e49dd2a9b4d719a18a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6829
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2000-01-06^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_009c3a669485d800e448a1b4c4bb223f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fa191caa343ecaaf5d6317ae581a37e |
| publicationDate |
2000-07-13^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0040270-A2 |
| titleOfInvention |
Methods of prolonging transplant survival using immunotoxins and costimulation blockade of cd154 and cd28 |
| abstract |
The present invention provides a method of preventing chronic rejection of a transplant in a recipient, comprising administering to the recipient an immunotoxin, thereby reducing the recipient's T-cell population and administering to the recipient a costimulation blocker or a combination of costimulation blockers, thereby reducing a transplant-specific antibody response. Also provided is the method of preventing chronic rejection of a transplant in a recipient, further comprising administering an immunosuppressive agent to the recipient. The present invention also provides a method of reversing a late acute rejection of a transplant in a recipient having a transplant that has survived for a prolonged period of time using the method of preventing chronic rejection, comprising monitoring the recipient for an indicator of a delayed acute rejection response and administering to the recipient showing the indicator of the acute rejection response an immunotoxin, thereby reducing the recipient's T-cell population. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7517527-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8217158-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010023482-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6632928-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7696338-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7288254-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8987426-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010023482-A2 |
| priorityDate |
1999-01-08^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |