| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a9420c46a1615ff274b406bd3285ad7f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-154
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2525-117 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6809
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6811 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-52 |
| filingDate |
2016-11-10^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a5eabc68184f4ee4bbb1be10fca558b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ebf217557e9a416def5d67509e9fa933
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c3b0c6a4bca48742c72d490b7a8cf6a |
| publicationDate |
2017-05-18^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017081689-A1 |
| titleOfInvention |
Methods of detecting 5-hydroxymethylcytosine and diagnosing of cancer |
| abstract |
A method of detecting the level of 5- hydroxymethylcytosines (5-hmc) in a DNA molecule of a cell having a 5-hmc prevalence lower than 0.002 % of total DNA bases is provided. The method comprising: (a) attaching a 5-hmc labeling agent to the DNA molecule; and (b) subjecting the DNA molecule to an imaging method suitable for detecting the labeling agent, thereby detecting the level of 5-hmc in the DNA molecule. Also provided is a method of diagnosing cancer in a subject in need thereof, the method comprising: (a) providing a DNA sample of a cell of the subject; (b) detecting the level of 5-hmc in the DNA sample as described herein; wherein a significant decrease in the level of 5-hmc in the DNA sample, as compared to a control DNA sample from a healthy subject is indicative that the subject has cancer. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11608518-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11091793-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113061652-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019234753-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10351898-B2 |
| priorityDate |
2015-11-11^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |