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Male development of chromosomally female mice transgenic for Sry.

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Affiliations

  • 1. Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK.
      Authors
    • Koopman P 1
    (1 author)

ORCIDs linked to this article

Nature, 01 May 1991, 351(6322):117-121
https://doi.org/10.1038/351117a0 PMID: 2030730 

A comment on this article appears in "Sex determination. The making of male mice." Nature. 1991 May 9;351(6322):96.

Abstract 

The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

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Medical Research Council (1)