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A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells.

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Affiliations

  • 1. Department of Molecular Biology, Scripps Clinic and Research Foundation, La Jolla, CA 92037.
      Authors
    • Fields PI 1
    (1 author)

Science, 01 Feb 1989, 243(4894 Pt 1):1059-1062
https://doi.org/10.1126/science.2646710 PMID: 2646710 

Abstract 

Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.

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Read article at publisher's site: https://doi.org/10.1126/science.2646710

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Funding 

Funders who supported this work.

NIAID NIH HHS (2)