Europe PMC

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy notice and cookie policy.

Brain levels of delta1-tetrahydrocannabinol and its metabolites in mice tolerant to the hypothermic effect of delta1-tetrahydrocannabinol.

British Journal of Pharmacology, 01 Oct 1973, 49(2):373-375
https://doi.org/10.1111/j.1476-5381.1973.tb08388.x PMID: 4793443 PMCID: PMC1776396

Free full text in Europe PMC

Abstract 

Repeated voluntary consumption of cannabis in milk (approximately 8 mg per day for 15 days) produced in mice tolerance to the hypothermic effect of tritiated Delta(1)-tetrahydrocannabinol ([(3)H]-Delta(1)-THC; 2 mg/kg i.v.) but not to the effect of [(3)H]-Delta(1)-THC on immobility index. The development of tolerance was not accompanied by any detectable change in levels of radioactivity in the brain assigned to Delta(1)-THC or its metabolites. It was concluded that changes in metabolism or distribution of Delta(1)-THC are not responsible for tolerance at least to the hypothermic effect of Delta(1)-THC in mice.

Free full text 

Logo of brjpharmLink to Publisher's site
Br J Pharmacol. 1973 Oct; 49(2): 373–375.
PMCID: PMC1776396
PMID: 4793443

Brain levels of Δ1-tetrahydro-cannabinol and its metabolites in mice tolerant to the hypothermic effect of Δ1-tetrahydrocannabinol

D. K. Lawrence and R. G. Pertwee
Copyright and License information Disclaimer

Abstract

Repeated voluntary consumption of cannabis in milk (approximately 8 mg per day for 15 days) produced in mice tolerance to the hypothermic effect of tritiated Δ1-tetrahydrocannabinol ([3H]-Δ1-THC; 2 mg/kg i.v.) but not to the effect of [3H]-Δ1-THC on immobility index. The development of tolerance was not accompanied by any detectable change in levels of radioactivity in the brain assigned to Δ1-THC or its metabolites. It was concluded that changes in metabolism or distribution of Δ1-THC are not responsible for tolerance at least to the hypothermic effect of Δ1-THC in mice.

Full text

Full text is available as a scanned copy of the original print version. Get a printable copy (PDF file) of the complete article (404K), or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.
 
icon of scanned page 373
373
icon of scanned page 374
374
icon of scanned page 375
375
 

Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Christensen HD, Freudenthal RI, Gidley JT, Rosenfeld R, Boegli G, Testino L, Brine DR, Pitt CG, Wall ME. Activity of delta8- and delta9-tetrahydrocannabinol and related compounds in the mouse. Science. 1971 Apr 9;172(3979):165–167. [Abstract] [Google Scholar]
  • Dewey WL, McMillan DE, Harris LS, Turk RF. Distribution of radioactivity in brain of tolerant and nontolerant pigeons treated with 3 H- 9 -tetrahydrocannabinol. Biochem Pharmacol. 1973 Feb 1;22(3):399–405. [Abstract] [Google Scholar]
  • Gill EW, Jones G. Brain levels of 1 -tetrahydrocannabinol and its metabolites in mice--correlation with behaviour, and the effect of the metabolic inhibitors SKF 525A and piperonyl butoxide. Biochem Pharmacol. 1972 Aug 15;21(16):2237–2248. [Abstract] [Google Scholar]
  • Gill EW, Jones G, Lawrence DK. Contribution of the metabolite 7-hydroxy-delta1-tetrahydrocannabinol towards the pharmacological activity of delta 1-tetrahydrocannabinol in mice. Biochem Pharmacol. 1973 Jan 15;22(2):175–184. [Abstract] [Google Scholar]
  • Ho BT, Estevez VS, Englert LF. Effect of repeated administration on the metabolism of (-)- 9 -tetrahydrocannabinols in rats. Res Commun Chem Pathol Pharmacol. 1973 Jan;5(1):215–218. [Abstract] [Google Scholar]
  • Jones G, Pertwee RG. A metabolic interaction in vivo between cannabidiol and 1 -tetrahydrocannabinol. Br J Pharmacol. 1972 Jun;45(2):375–377. [Europe PMC free article] [Abstract] [Google Scholar]
  • Paton WD, Pertwee RG. Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism. Br J Pharmacol. 1972 Feb;44(2):250–261. [Europe PMC free article] [Abstract] [Google Scholar]
  • Pertwee RG. The ring test: a quantitative method for assessing the 'cataleptic' effect of cannabis in mice. Br J Pharmacol. 1972 Dec;46(4):753–763. [Europe PMC free article] [Abstract] [Google Scholar]
Articles from British Journal of Pharmacology are provided here courtesy of The British Pharmacological Society

Full text links 

Read article at publisher's site: https://doi.org/10.1111/j.1476-5381.1973.tb08388.x

Read article for free, from open access legal sources, via Unpaywall: https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1973.tb08388.xUnpaywall

Citations & impact 

Impact metrics

9
Citations
Jump to Citations

Citations of article over time

Smart citations by scite.ai
Smart citations by scite.ai include citation statements extracted from the full text of the citing article. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles.
Explore citation contexts and check if this article has been supported or disputed.
https://scite.ai/reports/10.1111/j.1476-5381.1973.tb08388.x

Supporting
Mentioning
Contrasting
2
3
0

Article citations

Go to all (9) article citations

Similar Articles 

To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation.