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A metabolic interaction in vivo between cannabidiol and 1 -tetrahydrocannabinol.

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British Journal of Pharmacology, 01 Jun 1972, 45(2):375-377
https://doi.org/10.1111/j.1476-5381.1972.tb08092.x PMID: 5048656 PMCID: PMC1666148

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Abstract 

The effect of pretreatment with cannabidiol (CBD; 50 mg/kg i.p.) on the distribution of radioactivity in chromatograms of ethyl acetate extracts of the brains of mice injected with tritiated Delta(1)-tetrahydrocannabinol ((3)H-Delta(1)-THC; 1.0 mg/kg i.v.) was determined. The pretreatment with CBD produced significant increases in the levels of radioactivity in the brain assigned to Delta(1)-THC and its centrally active metabolite 7-hydroxy-Delta(1)-THC: the changes produced were respectively 1.4 and 2.0 fold.Pretreatment with CBD did not bring about any detectable change in the degree of 'catalepsy' produced by Delta(1)-THC. This negative finding may have been due to the wide limits of error that were obtained in the bioassay.

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Br J Pharmacol. 1972 Jun; 45(2): 375–377.
PMCID: PMC1666148
PMID: 5048656

A metabolic interaction in vivo between cannabidiol and Δ1-tetrahydrocannabinol

G. Jones and R. G. Pertwee
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Abstract

The effect of pretreatment with cannabidiol (CBD; 50 mg/kg i.p.) on the distribution of radioactivity in chromatograms of ethyl acetate extracts of the brains of mice injected with tritiated Δ1-tetrahydrocannabinol (3H-Δ1-THC; 1·0 mg/kg i.v.) was determined. The pretreatment with CBD produced significant increases in the levels of radioactivity in the brain assigned to Δ1-THC and its centrally active metabolite 7-hydroxy-Δ1-THC: the changes produced were respectively 1·4 and 2·0 fold.

Pretreatment with CBD did not bring about any detectable change in the degree of 'catalepsy' produced by Δ1-THC. This negative finding may have been due to the wide limits of error that were obtained in the bioassay.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.
  • Christensen HD, Freudenthal RI, Gidley JT, Rosenfeld R, Boegli G, Testino L, Brine DR, Pitt CG, Wall ME. Activity of delta8- and delta9-tetrahydrocannabinol and related compounds in the mouse. Science. 1971 Apr 9;172(3979):165–167. [Abstract] [Google Scholar]
  • Mechoulam R. Marihuana chemistry. Science. 1970 Jun 5;168(3936):1159–1166. [Abstract] [Google Scholar]
  • Mechoulam R, Shani A, Edery H, Grunfeld Y. Chemical basis of hashish activity. Science. 1970 Aug 7;169(3945):611–612. [Abstract] [Google Scholar]
  • Paton WD, Pertwee RG. Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism. Br J Pharmacol. 1972 Feb;44(2):250–261. [Europe PMC free article] [Abstract] [Google Scholar]
  • Wahlqvist M, Nilsson IM, Sandberg F, Agurell S. Binding of delta-1-tetrahydrocannabinol to human plasma proteins. Biochem Pharmacol. 1970 Sep;19(9):2579–2584. [Abstract] [Google Scholar]
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