KEGG   Ovis aries (sheep): 101109020
Entry
101109020         CDS       T03117                                 
Symbol
MTHFD1
Name
(RefSeq) C-1-tetrahydrofolate synthase, cytoplasmic isoform X2
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
oas  Ovis aries (sheep)
Pathway
oas00670  One carbon pool by folate
oas01100  Metabolic pathways
oas01240  Biosynthesis of cofactors
oas04981  Folate transport and metabolism
Module
oas_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:oas00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    101109020 (MTHFD1)
 09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    101109020 (MTHFD1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:oas04147]
    101109020 (MTHFD1)
Enzymes [BR:oas01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     101109020 (MTHFD1)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     101109020 (MTHFD1)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     101109020 (MTHFD1)
Exosome [BR:oas04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   101109020 (MTHFD1)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH
Other DBs
NCBI-GeneID: 101109020
NCBI-ProteinID: XP_004010764
UniProt: W5QJ32
LinkDB
Position
7:74627359..74690639
AA seq 935 aa
MAPAEILNGKVVSAQIKERLKNQVIQMKEEVPGFIPGLAILQVGNRDDSNLYINVKLKAA
EEIGIKAMHIKLPRTATESEVLKCITSLNEDLTVHGFIVQLPLDSENPINTETLVNAIAP
EKDVDGLNSISAGKLARGDLSNCFIPCTPKGCLELIKETGVQIAGRHAVVVGRSKIVGAP
MHDLLLWNHATVTTCHSKTANLNEEISKGDILVVAIGQPEMVKGEWIKPGAIVIDCGINY
VTDDTKPSGKKIVGDVAYMEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLENFKP
GEWIIEYNKLNLKTPVPSDIDISRSYKPKPIGNLAREIGLHTEEVELYGETKAKVRLSAL
ERLKHQPDGKYVVVTGITPTPLGEGKSTTTIGLVQALGAHLHQNVFACVRQPSQGPTFGI
KGGAAGGGYSQVIPMEEFNLHLTGDIHAITAANNLVAAAIDARMFHEETQTDKALFNRLV
PSVNGVRKFSDIQIRRLWRLGIEKTDPATLTDEEINRFARLDIDPETITWQRVLDTNDRF
LRKITIGQAPTEKGHSRTAQFDISVASEIMAVLALTSSLEDMRERLGKMVVASSKKGEPI
STEDLGVSGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFANIAHGNSSIIADRIALKLVG
PKGFVVTEAGFGADIGMEKFFNIKCRYSGLRPHVVVLVATVRALKMHGGGPTVTAGLPLP
KAYIEEDLELVGKGFSNLKKQIENARMFGVPVVVAVNAFKTDTEAELDLVSHLAKEHGAF
DAVKCTHWAEGGKGALALAEAVQRAAAAPSNFQLLYDLKLPVEDKIRIIAQKIYGADDIE
LLPEAQHKAEVYTKQGFGNLPICMAKTHLSLSHNPELKGVPTGFVLPIRDIRASVGAGFL
YPLVGTMSTMPGLPTRPCFYDIDLDPETEQVNGLF
NT seq 2808 nt   +upstreamnt  +downstreamnt
atggcgccggcggaaatcctgaacgggaaggtggtctccgcgcaaataaaggagagactg
aagaaccaagtcattcagatgaaggaggaagtacctggtttcataccaggcctggcaatt
ttacaggttggcaacagagatgactctaatctttatataaatgtgaagttgaaggctgct
gaggagatcgggatcaaagccatgcacattaagttaccccgaacggccacggaatctgag
gtgttaaagtgcatcacatcattgaacgaagacctcactgtgcatgggttcatagtgcag
ctgcctttagattcagagaatcccattaacactgaaacactggtcaatgctattgccccc
gaaaaagatgtggacggactgaatagcatcagtgctggaaaacttgctagaggggacctt
agtaactgtttcatcccttgtacacccaaaggatgcttggaactcatcaaggagacaggg
gtgcaaattgccggaaggcatgctgtggtggtcgggcgcagtaaaatcgttggtgcccca
atgcatgacttgcttctatggaaccatgccacagtgaccacctgccactccaagactgcc
aatctgaacgaggagataagtaaaggtgacatcctggtggttgcaattggtcaacctgaa
atggtgaaaggggagtggatcaaacctggggcgatagtcattgactgtggaatcaattac
gtcacagatgatacaaaaccaagtgggaagaaaattgtgggtgatgtagcgtacatggaa
gccaaggagagggcaagctttatcacccctgttcctggtggcgtcgggcccatgacagtg
gcaatgctaatgcagagcacagtagagagtgcaaagcgcttcttggagaactttaagcca
ggggagtggatcatcgagtataacaaacttaacctgaagacgcccgtgccaagtgacatt
gatatatcacggtcttacaagccaaagcccattggtaacctggctcgagaaattggtctg
cacactgaagaggtagaattgtacggtgaaaccaaggcaaaagttcggctctcagcgctg
gaacggctgaagcaccagcctgatgggaaatatgtggtggtaaccggaatcactccaaca
cccctgggagaggggaaaagcacaaccacgattggcctggtgcaggccctcggcgcccat
ctccatcagaatgtctttgcgtgtgtgcgacagccttctcaggggcccacctttgggata
aaaggtggcgctgcaggcggtggctactctcaggtcattcctatggaagagtttaatctc
cacctcactggtgacatccatgccatcactgcagctaataaccttgtggccgcagccatc
gatgcccgtatgttccatgaagagacccagacagacaaggctctttttaatcgtttggtg
ccatcagtaaatggagtgagaaagttctctgatatccaaatccggaggttatggagacta
ggcattgaaaagactgaccctgccacactgacagatgaagagataaacagatttgcaaga
ctggacattgatccagaaactattacttggcaaagagtgctggataccaatgatagattc
ctgaggaagatcacgatcggacaggctccaacggagaaggggcattcacggacggctcag
tttgatatctctgtggccagtgaaatcatggctgtcctggctctcaccagttctctagaa
gacatgagagagagactgggcaaaatggtggtggcgtccagcaagaaaggggagcccatc
agtactgaggatctgggagtgagtggagcattgacggtccttatgaaggatgccatcaag
cccaatctcatgcagacattagagggcactccagtgtttgttcacgctgggccatttgcc
aacatcgcacacgggaattcctccatcattgcagacaggattgcactcaagcttgtcggt
cccaaagggtttgtagtgactgaagcaggattcggagcagacattggaatggaaaagttc
ttcaacatcaagtgccggtattctggtctccgcccgcacgtggtggtgcttgtcgccacc
gtcagggctctgaaaatgcatggaggtggccccacggttactgctggacttccgcttccc
aaggcctacatagaggaggacctggagctggttggaaaaggcttcagtaacttgaagaag
caaattgaaaatgccaggatgtttggtgtgccagtggtagtggccgtgaatgccttcaag
acagatacagaggccgagctggacctcgtcagccacctcgccaaagaacatggtgctttt
gacgccgtgaagtgcactcactgggcagaagggggcaagggtgccctggcgctggctgag
gccgtccagagggcagctgcggcccccagcaacttccagctcctctacgacctcaagctc
ccagtcgaggacaaaatcaggattattgcacagaagatctatggagctgacgacatcgaa
ttgctccctgaagcccagcacaaagcagaagtctacacaaagcagggctttgggaatctg
cccatctgcatggccaagacacacttgtccttgtctcacaacccagagctaaaaggcgtg
cctactggcttcgtcctgcccattcgcgacatccgcgccagcgtcggggccggctttctg
taccctctggtgggaacgatgagcaccatgcctggactccctactcggccctgtttctat
gatattgatttggacccggaaactgagcaggtgaatgggctgttctaa

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