KEGG ORTHOLOGY: K00288

ORTHOLOGY: K00288

Entry

K00288                      KO

Symbol

MTHFD

Name

methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]

Pathway

map00670

One carbon pool by folate

map01100

Metabolic pathways

map01120

Microbial metabolism in diverse environments

map01240

Biosynthesis of cofactors

map04981

Folate transport and metabolism

Module

M00141

C1-unit interconversion, eukaryotes

Reaction

R00943

formate:tetrahydrofolate ligase (ADP-forming)

R01220

5,10-methylenetetrahydrofolate:NADP+ oxidoreductase

R01655

5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)

Disease

H00262

Neural tube defects, folate-sensitive

H02761

Combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
09150 Organismal Systems
  09154 Digestive system
   04981 Folate transport and metabolism
    K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase

Other DBs

GO:	0004488 0004477 0004329

Genes

HSA:	4522(MTHFD1)

PTR:	452965(MTHFD1)

PPS:	100986093(MTHFD1)

GGO:	101145772(MTHFD1)

PON:	100173036(MTHFD1)

PPYG:

129013312(MTHFD1)

NLE:	100592446(MTHFD1)

HMH:	116485152(MTHFD1)

SSYN:

129487773(MTHFD1)

MCC:	707059(MTHFD1)

MCF:	102146226(MTHFD1)

MTHB:

126959748

MNI:	105473695(MTHFD1)

CSAB:

103229163(MTHFD1)

CATY:

105582920(MTHFD1)

PANU:

101014176 116275895(MTHFD1)

TGE:	112628453(MTHFD1)

MLEU:

105538460(MTHFD1)

RRO:	104678419(MTHFD1)

RBB:	108542410(MTHFD1)

TFN:	117069476(MTHFD1)

PTEH:

111555804(MTHFD1)

CANG:

105517339(MTHFD1)

CJC:	100385373(MTHFD1)

SBQ:	101050716(MTHFD1)

CIMI:

108308242(MTHFD1)

ANAN:

105725183(MTHFD1)

CSYR:

103275244(MTHFD1)

MMUR:

105856425 105878372(MTHFD1)

LCAT:

123648090(MTHFD1)

PCOQ:

105819731(MTHFD1)

OGA:	100946648(MTHFD1)

MMU:	108156(Mthfd1)

MCAL:

110306712(Mthfd1)

MPAH:

110324943(Mthfd1)

RNO:	64300(Mthfd1) 680432(Mthfd1-ps1)

MCOC:

116080147(Mthfd1)

ANU:	117697507(Mthfd1)

MUN:	110547762(Mthfd1)

CGE:	100763862(Mthfd1)

MAUA:

101827588(Mthfd1)

PROB:

127230708(Mthfd1)

PLEU:

114697741(Mthfd1)

MORG:

121452424(Mthfd1)

MFOT:

126508400

AAMP:

119819126(Mthfd1)

NGI:	103730291 103749265(Mthfd1)

HGL:	101707403(Mthfd1)

CPOC:

100734825(Mthfd1)

CCAN:

109691124(Mthfd1)

DORD:

105984857(Mthfd1)

DSP:	122110013(Mthfd1)

PLOP:

125363077(Mthfd1)

NCAR:

124977898

MMMA:

107146007(Mthfd1)

OCU:

100347271

OPI:	101521869(MTHFD1)

TUP:	102473748(MTHFD1)

GVR:	103585325(MTHFD1)

CFA:	480352(MTHFD1)

CLUD:

112657526(MTHFD1)

VVP:	112922441 112927162(MTHFD1)

VLG:	121493082(MTHFD1)

NPO:	129495978(MTHFD1)

AML:	100467466(MTHFD1)

UMR:	103672303(MTHFD1)

UAH:	113246307(MTHFD1)

UAR:	123800680(MTHFD1)

ELK:

111139993

LLV:	125092829 125103679

MPUF:

101675940(MTHFD1)

MNP:	131999442(MTHFD1)

MLK:	131836674(MTHFD1)

NVS:	122894485(MTHFD1)

ORO:	101381197(MTHFD1)

EJU:	114218032(MTHFD1)

ZCA:	113909448(MTHFD1)

MLX:	118002597(MTHFD1)

NSU:	110590611(MTHFD1)

FCA:	101086816(MTHFD1)

PYU:	121031892(MTHFD1)

PCOO:

112856302(MTHFD1)

PBG:	122469207(MTHFD1)

PVIV:

125167730(MTHFD1)

LRUF:

124512125

PTG:	102971656(MTHFD1)

PPAD:

109268333(MTHFD1)

PUC:

125908710

AJU:

106971326

HHV:	120238417(MTHFD1)

BTA:	534382(MTHFD1)

BOM:	102275233(MTHFD1)

BIU:	109565242(MTHFD1)

BBUB:

102414409(MTHFD1)

BBIS:

104993488(MTHFD1)

CHX:	102186214(MTHFD1)

OAS:	101109020(MTHFD1)

BTAX:

128054627(MTHFD1)

CSUM:

138073668(MTHFD1)

ODA:	120852813(MTHFD1)

CCAD:

122443744(MTHFD1)

MREE:

136172396(MTHFD1)

MBEZ:

129563010(MTHFD1)

SSC:	414382(MTHFD1)

CFR:	102504065(MTHFD1)

CBAI:

105074665(MTHFD1)

CDK:	105086194(MTHFD1)

VPC:	102527060(MTHFD1)

BACU:

103017005(MTHFD1)

BMUS:

118889664(MTHFD1)

LVE:	103090767(MTHFD1)

OOR:	101275041(MTHFD1)

DLE:	111173070(MTHFD1)

PCAD:

102996417(MTHFD1)

PSIU:

116749725(MTHFD1)

NASI:

112403403(MTHFD1)

ECB:	100062154(MTHFD1)

EPZ:	103559580(MTHFD1)

EAI:	106840123(MTHFD1)

MYB:	102241254(MTHFD1)

MYD:	102757978(MTHFD1)

MMYO:

118656389(MTHFD1)

MLF:	102427801(MTHFD1)

MDT:	132233292(MTHFD1)

PKL:	118716826(MTHFD1)

EFUS:

103283910(MTHFD1)

MNA:	107545676(MTHFD1)

DRO:	112311419(MTHFD1)

SHON:

118976948(MTHFD1)

AJM:	119034794(MTHFD1)

PDIC:

114491521(MTHFD1)

PHAS:

123807947(MTHFD1)

MMF:	118625248(MTHFD1)

PPAM:

129065967(MTHFD1)

HAI:	109382053(MTHFD1)

RFQ:	117023448(MTHFD1)

PALE:

102878910(MTHFD1)

PGIG:

120612739(MTHFD1)

PVP:	105308494(MTHFD1)

RAY:	107509318(MTHFD1)

MJV:	108396567(MTHFD1)

TOD:	119239179(MTHFD1)

SARA:

101558074(MTHFD1)

SETR:

126003976(MTHFD1)

LAV:	100661814(MTHFD1)

TMU:

101351465

ETF:	101661891(MTHFD1)

DNM:	101418604(MTHFD1)

MDO:	100027684(MTHFD1)

GAS:	123237742(MTHFD1)

SHR:	100917465(MTHFD1)

AFZ:

127549617

PCW:	110220613(MTHFD1)

TVP:	118828517(MTHFD1)

PBRV:

138156877(MTHFD1)

OAA:	100079541(MTHFD1)

GGA:	423508(MTHFD1)

PCOC:

116236792(MTHFD1)

MGP:	100542376(MTHFD1)

CJO:	107315290(MTHFD1)

TPAI:

128086705(MTHFD1)

LMUT:

125694871(MTHFD1)

NMEL:

110401467(MTHFD1)

APLA:

101798457(MTHFD1)

ACYG:

106037251(MTHFD1)

CATA:

118250230(MTHFD1)

AFUL:

116489688(MTHFD1)

TGU:	100218066(MTHFD1)

LSR:	110484120(MTHFD1)

SCAN:

103826371(MTHFD1)

PMOA:

120513525(MTHFD1)

OTC:	121333550(MTHFD1)

PRUF:

121358274(MTHFD1)

GFR:	102040140(MTHFD1)

FAB:	101820743(MTHFD1)

OMA:	130253649(MTHFD1)

PHI:	102101641(MTHFD1)

PMAJ:

107206040(MTHFD1)

CCAE:

111945273 111945401

CCW:	104687153(MTHFD1)

CBRC:

103618870(MTHFD1)

ETL:	114063210(MTHFD1)

ZAB:	102073134(MTHFD1)

ZLE:	135448400(MTHFD1)

ACHL:

103804597(MTHFD1)

SVG:	106850203(MTHFD1)

MMEA:

130584044(MTHFD1)

HRT:	120754302(MTHFD1)

SATI:

136362806(MTHFD1)

FPG:	101913340(MTHFD1)

FCH:	102059574(MTHFD1)

CCRI:

104168707(MTHFD1)

NNT:	104408401(MTHFD1)

SHAB:

115607305(MTHFD1)

ACUN:

113480420(MTHFD1)

TALA:

104355634(MTHFD1)

ACHC:

115349523(MTHFD1)

HALD:

104319058(MTHFD1)

HLE:	104842059(MTHFD1)

AGEN:

126050660

GCL:

127017105

CSTI:

104550042(MTHFD1)

LDI:

104339760

MNB:	103773569(MTHFD1)

DPUB:

104303027(MTHFD1)

PPUS:

135182997(MTHFD1)

AVIT:

104267930(MTHFD1)

BRHI:

104497789(MTHFD1)

EGZ:	104131673(MTHFD1)

NNI:	104010143(MTHFD1)

PCRI:

104035134(MTHFD1)

PCAO:

104039571

PADL:

103924255(MTHFD1)

AFOR:

103894073(MTHFD1)

FGA:

104079849

GSTE:

104257396(MTHFD1)

CLV:	102091689(MTHFD1)

MUI:	104546751(MTHFD1)

PGUU:

104472008(MTHFD1)

PLET:

104614102(MTHFD1)

EHS:	104502802(MTHFD1)

CMAC:

104484634(MTHFD1)

CUCA:

104062339(MTHFD1)

TEO:	104382482(MTHFD1)

BREG:

104643318(MTHFD1)

OHA:	104336992(MTHFD1)

ACAR:

104528081(MTHFD1)

CPEA:

104391399(MTHFD1)

CVF:	104291912(MTHFD1)

RTD:	128908683(MTHFD1)

AAM:	106483010(MTHFD1)

AROW:

112976925(MTHFD1)

NPD:	112947190(MTHFD1)

TGT:	104567974(MTHFD1)

DNE:	112991525(MTHFD1)

SCAM:

104144511(MTHFD1)

ASN:	102377792(MTHFD1)

AMJ:	102576903(MTHFD1)

CPOO:

109320648(MTHFD1)

GGN:	109298383(MTHFD1)

PSS:	102452269(MTHFD1)

CMY:	102943369(MTHFD1)

CCAY:

125638181(MTHFD1)

DCC:	119857075(MTHFD1)

CPIC:

101941983(MTHFD1)

TST:	117876176(MTHFD1)

CABI:

116821306(MTHFD1)

MRV:	120403518(MTHFD1)

ACS:	100553949(mthfd1)

ASAO:

132761444(MTHFD1)

PVT:	110082847(MTHFD1)

SUND:

121919844(MTHFD1)

PBI:	103058437(MTHFD1)

PMUR:

107285163(MTHFD1)

CTIG:

120305320(MTHFD1)

TSR:	106542509(MTHFD1)

PGUT:

117675173(MTHFD1)

APRI:

131187997(MTHFD1)

PTEX:

113435063(MTHFD1)

NSS:	113413748(MTHFD1)

VKO:	123026675(MTHFD1)

PMUA:

114603772(MTHFD1)

PRAF:

128421661(MTHFD1)

ZVI:	118079842(MTHFD1)

HCG:	128339839(MTHFD1)

GJA:	107119326(MTHFD1)

STOW:

125426395(MTHFD1)

EMC:	129323332(MTHFD1)

XLA:	380266(mthfd1.L)

XTR:	493369(mthfd1)

NPR:	108787125(MTHFD1)

RTEM:

120920700(MTHFD1)

BBUF:

120982524(MTHFD1)

BGAR:

122921873(MTHFD1)

MUO:	115477723(MTHFD1)

GSH:	117363702(MTHFD1)

DRE:	260441(mthfd1b) 567587(mthfd1a)

SRX:	107711662 107719198 107721369 107728958

SANH:

107668238 107675313(mthfd1)

SGH:	107562682 107571064(mthfd1) 107602204

CCAR:

109107607

CAUA:

113062896 113062983 113117000(mthfd1)

CGIB:

127938889 127975842

PTET:

122325003(mthfd1a) 122362215 122362245(mthfd1b)

LROH:

127179870(mthfd1b) 127183287(mthfd1a)

OMC:	131522978(mthfd1b) 131526759(mthfd1a)

PPRM:

120462370(mthfd1b) 120494079(mthfd1a)

RKG:	130088922(mthfd1b) 130089128(mthfd1a)

MAMB:

125268409(mthfd1b) 125277939(mthfd1a)

CIDE:

127498593

CERY:

137007108(mthfd1b) 137018990(mthfd1a)

MASI:

127409868 127454900

TROS:

130560251(mthfd1b) 130565654(mthfd1a)

TDW:	130434065(mthfd1a) 130436970(mthfd1b)

MANU:

129426621(mthfd1b)

IPU:	108257577(mthfd1a) 108269612(mthfd1b)

IFU:	128600920(mthfd1a) 128612678(mthfd1b)

PHYP:

113538830(mthfd1) 113547678

SMEO:

124376982(mthfd1a) 124390339(mthfd1b)

TFD:	113653759(mthfd1a) 113659631(mthfd1b)

TVC:	132843053(mthfd1a) 132852775(mthfd1b)

TRN:	134320132(mthfd1a) 134325253(mthfd1b)

AMEX:

103042181(mthfd1b) 103044195(mthfd1a)

CMAO:

118815677(mthfd1a) 118823931(mthfd1b)

EEE:	113570496 113579870

CHAR:

105897087(mthfd1a) 105908326(mthfd1b)

TRU:	101079275(mthfd1)

TFS:	130513290(mthfd1b)

TNG:	GSTEN00032425G001

LCO:	104924805(mthfd1)

NCC:	104947195(mthfd1)

TBEN:

117476391(mthfd1b)

CGOB:

115026983

PGEO:

117467835(mthfd1b)

GACU:

117550107(mthfd1b)

EMAC:

134882028

ELY:	117267507(mthfd1b)

EFO:	125900454(mthfd1b)

PLEP:

121953795(mthfd1b)

SLUC:

116035453(mthfd1b)

ECRA:

117935578(mthfd1b)

ESP:	116670666(mthfd1)

PFLV:

114546438(mthfd1)

GAT:	120832525(mthfd1b)

PPUG:

119227835(mthfd1b)

AFB:	129103406(mthfd1b)

CLUM:

117751685(mthfd1b)

PSWI:

130201751(mthfd1b)

CANA:

137787371

CVE:	137880301(mthfd1b)

MSAM:

119909874(mthfd1b)

SCHU:

122861326(mthfd1b)

CUD:	121526513(mthfd1b)

ALAT:

119004743(mthfd1b)

ASTR:

137610660(mthfd1b)

MZE:	101477222(mthfd1)

ONL:	100709978(mthfd1)

OAU:	116322325(mthfd1b)

OLA:

101174548

OML:	112144482(mthfd1b)

CSAI:

133462325(mthfd1b)

XMA:	102224500(mthfd1)

XCO:

114133834

XHE:	116708634(mthfd1)

PRET:

103458564(mthfd1)

PFOR:

103136077

PLAI:

106952296

PMEI:

106913912(mthfd1)

GAF:	122846493(mthfd1b)

PPRL:

129365450(mthfd1b)

CVG:	107094373(mthfd1)

CTUL:

119789559(mthfd1b)

GMU:	124855873(mthfd1b)

NFU:	107392490(mthfd1)

KMR:	108232073(mthfd1b)

ALIM:

106519747

NWH:	119427404(mthfd1b)

AOCE:

111577893(mthfd1)

EJA:

138199776

MCEP:

125024013(mthfd1b)

CSEM:

103390162(mthfd1)

SSEN:

122783447(mthfd1b)

HHIP:

117755494(mthfd1b)

HSP:	118116475(mthfd1b)

PPLT:

128450648(mthfd1b)

SMAU:

118286426(mthfd1b)

LCF:

108892567

SDU:

111225814

SLAL:

111652470(mthfd1)

XGL:	120795619(mthfd1b)

HCQ:	109526130(mthfd1)

SSCV:

125980541(mthfd1b)

SBIA:

133513599(mthfd1b)

PEE:	133412982(mthfd1b)

PTAO:

133487508(mthfd1b)

BPEC:

110155272

MALB:

109968362

BSPL:

114848926(mthfd1b)

SJO:	128375033(mthfd1b)

SASA:

106581504(mthfd1) 106607641

STRU:

115172681(mthfd1) 115195466

OTW:	112217304 112261855(mthfd1b)

OMY:	110497985(mthfd1b) 110521990

OGO:	123994936 124001554

ONE:	115140432 115146277(mthfd1)

OKI:	109880233 109894554(mthfd1)

OKE:	118362415(mthfd1b) 118386744

SALP:

111968792(mthfd1) 111973247

SNH:	120019604 120060253

CCLU:

121539218 121544975 121549134

ELS:	105015635(mthfd1) 105021712

SFM:	108919610(mthfd1)

PKI:	111838814(mthfd1)

AANG:

118226224(mthfd1b) 118229883

LOC:	102692950(mthfd1)

PSPA:

121330102(mthfd1b)

ARUT:

117424974

PSEX:

120518354

LCM:	102347033(MTHFD1)

CMK:	103189752(mthfd1b)

RTP:	109912330(mthfd1b)

CPLA:

122553329(mthfd1b)

HOC:	132818443(mthfd1b)

LERI:

129700079(mthfd1b)

PMRN:

116953991 116954031(MTHFD1)

LRJ:	133356259(MTHFD1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG4067(pug)

DER:

6551976

DSE:

6606937

DSI:	Dsimw501_GD18702(Dsim_GD18702)

DYA:	Dyak_GE26043

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23694

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:	108363099 108373538 108376827

AOQ:

TDA:

MDE:

SCAC:

LSQ:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ014099

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105668747(pug)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124222828(pug)

NFB:

NLO:

NVG:

AROA:

TCA:	656820 656994

DPA:	109533007 109542585

SOY:

115889394

AGRG:

126735876

ATD:	109594139 109594638

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:	111422780 111422876

BMOR:

101743494

BMAN:

114247836

MSEX:

115443407

DPL:	KGM_211321

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137919646(pug)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106689024(pug)

NLU:

111052053

HVI:

124370947

MQU:

128985942

PHU:	Phum_PHUM025050 Phum_PHUM456190

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

IEL:	124167525 124167764

FCD:

110845338

DPX:	DAPPUDRAFT_106818 DAPPUDRAFT_198836

DMK:

116922782

DPZ:

124343456

AFRA:

136026287

PVM:	113804944 113819971

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123761672(pug)

CQD:

128689068

PTRU:

123517529

ESN:

127009976

MNZ:	135207583 135207585

MRJ:	136850865(pug)

HAZT:

EAF:

LSM:

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136978572(pug)

UDV:

129227821

LPOL:

106463248

PMEO:

129585035

CEL:	CELE_K07E3.4(K07E3.4)

CBR:

CBG_27847

CRQ:	GCK72_024898

NAI:	NECAME_02558

TSP:

Tsp_00651

HRO:	HELRODRAFT_104956

LGI:	LOTGIDRAFT_201055

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

HASI:

CRG:

CANU:

CVN:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_49681

AQU:

100634307

CCP:	CHC_T00009198001

SCE:	YBR084W(MIS1) YGR204W(ADE3)

SEUB:

DI49_1117 DI49_2171

SPAO:

SPAR_B01860 SPAR_G04170

AGO:	AGOS_ACL121C AGOS_AER178W

ERC:	Ecym_7378 Ecym_7435

KLA:	KLLA0_E12475g KLLA0_E16545g

KMX:	KLMA_60087(ADE3) KLMA_70359(MIS1)

LTH:	KLTH0B01496g KLTH0E14366g

VPO:	Kpol_1050p36 Kpol_243p3

ZRO:	ZYRO0G11550g ZYRO0G12936g

CGR:	2890148(GVI51_K00759) 2891188(GVI51_M01595)

NCS:	NCAS_0A07290(NCAS0A07290) NCAS_0I01350(NCAS0I01350)

NDI:	NDAI_0A07650(NDAI0A07650) NDAI_0D02270(NDAI0D02270)

TPF:	TPHA_0A03820(TPHA0A03820) TPHA_0A04840(TPHA0A04840)

TBL:	TBLA_0B07610(TBLA0B07610) TBLA_0I02160(TBLA0I02160)

TGB:	HG536_0D04150 HG536_0E05050

TDL:	TDEL_0E04950(TDEL0E04950) TDEL_0F02070(TDEL0F02070)

KAF:	KAFR_0B04020(KAFR0B04020) KAFR_0C00240(KAFR0C00240)

KNG:	KNAG_0G00770(KNAG0G00770) KNAG_0J02370(KNAG0J02370)

ZMK:	HG535_0A03250 HG535_0B00580

SLUD:

SCDLUD_000752 SCDLUD_004660

DHA:	DEHA2E18414g DEHA2G23650g

PIC:	PICST_80013(MIS1) PICST_88119(ADE3)

PGU:	PGUG_01248 PGUG_04085

SPAA:

SPAPADRAFT_134523(ADE3) SPAPADRAFT_49629

LEL:	PVL30_000051(MIS1_1) PVL30_002726(ADE3)

LBG:	92206238(LODBEIA_P10420) 92206933(LODBEIA_P17370)

CAL:	CAALFM_CR00080WA(MIS12) CAALFM_CR07010WA(MIS11)

CTP:	CTRG_03112

COT:	CORT_0A00680 CORT_0D04820

CDU:	CD36_25100 CD36_32540

CTEN:

18250840(MIS1) 18250850(ADE3)

CLU:	CLUG_02470 CLUG_03993

CLUS:

A9F13_01g01298 A9F13_28g00319

CAUR:

CJI96_0000520 CJI96_0003912

PPA:	PAS_chr1-4_0632

PKZ:	C5L36_0A01550 C5L36_0B04390

BNN:	FOA43_000962(ADE3) FOA43_002991(MIS1)

BBRX:

BRETT_001568(MIS1_1) BRETT_003752(MIS1_2)

OPA:	HPODL_02628 HPODL_04374

YLI:	2907923(YALI2_E00903g) 2912574(YALI2_E01742g)

SLB:	AWJ20_1713(MIS1) AWJ20_943(MIS1)

NCR:

NCU03877

NTE:	NEUTE1DRAFT88125(NEUTE1DRAFT_88125)

SMP:	10803251(SMAC4_06300)

PAN:	PODANSg944

PBEL:

QC761_402740(ADE3)

PPSD:

QC762_402740(ADE3)

PPSP:

QC763_402740(ADE3)

PPSA:

QC764_402740(ADE3)

TTT:	THITE_2110770

MTM:	MYCTH_2307368

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_1000

SSCK:

SPSK_10843

FGR:	FGSG_10267

FPU:	FPSE_03604

FPOA:

FPOAC1_003371

FVN:	FVRRES_03718

FVR:	FVEG_02948

FOX:	FOXG_05185

NHE:	NECHADRAFT_60993

FFC:	NCS54_00680800

FKR:	NCS57_00720600

FMU:	J7337_005855

TRE:	TRIREDRAFT_75890

TRR:	M419DRAFT_95812

TATV:

25775923(TrAtP1_004725)

TASP:

36607349(TrAFT101_004153)

MAW:	19252051(ADE3_1)

MAJ:

MAA_00020

MBRN:

26245681(C1TC)

PCHM:

VFPPC_00144

AMUS:

LMH87_011782

PLJ:	28891610(PLICBS_010335)

PTKZ:

JDV02_002223(ADE3)

VAL:	VDBG_04290

VDA:	VDAG_01520

CFJ:	CFIO01_11507

CLUP:

CLUP02_10219

CHIG:

CH63R_09355

CDET:

87950550(CDEST_14050)

SAPO:

SAPIO_CDS10729

ELA:	UCREL1_10121

PFY:	PFICI_06587

SSL:	SS1G_03895

BFU:	BCIN_04g03040

PSCO:

LY89DRAFT_738559

GLZ:	GLAREA_07222

ANI:	ANIA_02998

AFM:	AFUA_3G08650

ACT:	ACLA_036640

NFI:	NFIA_068470

AOR:	AO090005001405

ANG:	An02g12420

AFV:	AFLA_004224

ALUC:

AKAW2_11035S(ADE3)

ACHE:

ACHE_70059A(ADE3)

APUU:

APUU_30548S(ADE3)

PCS:	N7525_008800

PDP:	PDIP_08760

POU:	POX_g08741

TMF:	EYB26_009777

TRG:	TRUGW13939_04511

CIM:	CIMG_07671

CPW:	9693470(ADE3)

URE:	UREG_07615

ABE:

ARB_04625

TVE:

TRV_06219

PBL:	PAAG_08349

PBN:	PADG_04250

AJE:	HCAG_04357

BGH:	BDBG_02002

PNO:	SNOG_01593(SNOG_01592)

PTE:

PTT_13570

PTRR:

6340912(PtrM4_062590)

BZE:	COCCADRAFT_23976

BSC:	COCSADRAFT_22292

BOR:	COCMIDRAFT_9531

AALT:

CC77DRAFT_926730

ARAB:

EKO05_0010476

ZTR:	MYCGRDRAFT_52059

PFJ:	MYCFIDRAFT_163981

FFU:	CLAFUR5_04049

CBET:

CB0940_12186

BCOM:

BAUCODRAFT_27658

NPA:	UCRNP2_7472

TML:	GSTUM_00011854001

SPO:	2540300(ade9) 2541217(thf1)

SOM:	SOMG_00130(ade9) SOMG_02305(thf1)

CNE:

CNG00590

CNB:

CNBG4190

CNG:	CNAG_07746

CGI:	CGB_G6120C

CDEU:

CNBG_2078

CDEP:

91085647(L203_101434)

KMG:	30159905(I203_104964)

KNE:	92180552(IAR55_003294)

TMS:	TREMEDRAFT_32433

TASA:

A1Q1_07904

CCAC:

CcaHIS019_0508450(ADE3)

TVS:	TRAVEDRAFT_45346

DSQ:	DICSQDRAFT_124115

PCO:	PHACADRAFT_256172

SHS:	STEHIDRAFT_119085

HIR:	HETIRDRAFT_122342

PSQ:	PUNSTDRAFT_114825

ADL:	AURDEDRAFT_114390

FME:	FOMMEDRAFT_127750

GTR:	GLOTRDRAFT_119984

RSX:	RhiXN_04163

LBC:	LACBIDRAFT_187631

CCI:	CC1G_13910

ABP:	AGABI1DRAFT118122(AGABI1DRAFT_118122)

ABV:	AGABI2DRAFT183212(AGABI2DRAFT_183212)

PCUB:

JR316_0003739

MPR:	MPER_10594

MRR:	Moror_6556

E1B28_008814

SCM:	SCHCO_02607767(SCHCODRAFT_02607767)

CPUT:

CONPUDRAFT_49023

SLA:	SERLADRAFT_454136

WSE:	WALSEDRAFT_31760

WIC:	J056_002521

UMA:	UMAG_10840

PFP:	PFL1_05629

SGRA:

MGL:

MRT:

MSYM:

PGR:	PGTG_15310

PTRC:

PtA15_7A773

PSTR:

Pst134EA_033447

MLR:	MELLADRAFT_102871

RIE:	OCT59_005556

MBR:	MONBRDRAFT_7587

SRE:	PTSG_09498

TGO:	TGME49_257625

TCR:

511741.50

LMA:	LMJF_30_2600(FTHS)

LIF:	LINJ_30_2590(FTHS)

LDO:	LDBPK_302590

LMI:	LMXM_29_2600

LMAT:

92513921(LSCM1_03876)

LBZ:	LBRM_30_2550(FTHS)

LPAN:

LPMP_302520(FTHS)

LOI:	92358144(LSCM4_02176)

LEIS:

94178318(GH5_02817)

LENR:

94170410(CUR178_03164)

LEIN:

94187218(JIQ42_03541)

PHET:

94289145(JKF63_03046)

» show all

Reference

PMID:3053686

Authors

Hum DW, Bell AW, Rozen R, MacKenzie RE

Title

Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.

Journal

J Biol Chem 263:15946-50 (1988)

Sequence

[hsa:4522]

Reference

PMID:12384833

Authors

Brody LC, Conley M, Cox C, Kirke PN, McKeever MP, Mills JL, Molloy AM, O'Leary VB, Parle-McDermott A, Scott JM, Swanson DA

Title

A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group.

Journal

Am J Hum Genet 71:1207-15 (2002)
DOI:10.1086/344213

LinkDB

DBGET integrated database retrieval system