KEGG   PATHWAY: btax04723
Entry
btax04723                   Pathway                                
Name
Retrograde endocannabinoid signaling - Budorcas taxicolor (takin)
Description
Endogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic acid; the two best characterized are arachydonoyl ethanolamide (anandamide, AEA) and 2-arachydonoil glycerol (2AG). They are released from postsynaptic neurons upon postsynaptic depolarization and/or receptor activation. The released endocannabinoids then activate the CB1 receptors (CB1R) at presynaptic terminals and suppress the release of inhibitory transmitter GABA (depolarization-induced suppression of inhibition, DSI) or excitatory transmitter glutamate (depolarization-induced suppression of excitation, DSE) by inhibiting Ca2+ channels. Besides the well-known expression of the CB1R in the plasma membrane, this receptor is also present in mitochondrial membranes, where it reduces the mitochondrial respiration and contributes to DSI. Whereas DSI and DSE result in short-term synaptic plasticity, endocannabinoids also mediate long-term synaptic changes (eCB-LTD). Persistent activation of CB1 receptors over a period of minutes triggers eCB-LTD by a RIM1alpha-dependent mechanism.
Class
Organismal Systems; Nervous system
Pathway map
btax04723  Retrograde endocannabinoid signaling
btax04723

Other DBs
GO: 0071926
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128063550  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
128048425  SLC17A8; vesicular glutamate transporter 3 [KO:K12302]
128068884  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
128050386  GRIA1; glutamate receptor 1 [KO:K05197]
128062005  GRIA2; glutamate receptor 2 [KO:K05198]
128069759  GRIA3; glutamate receptor 3 [KO:K05199]
128060086  GRIA4; glutamate receptor 4 [KO:K05200]
128048945  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
128052044  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
128070004  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
128061188  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
128053357  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
128068942  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
128052307  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
128058011  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
128058303  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
128054050  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
128068545  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
128046429  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
128048527  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
128056281  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
128046538  NAPEPLD; N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D isoform X1 [KO:K13985] [EC:3.1.4.54]
128065393  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
128066420  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
128063096  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
128043464  DAGLB; diacylglycerol lipase-beta [KO:K13806] [EC:3.1.1.116]
128068690  DAGLA; diacylglycerol lipase-alpha [KO:K13806] [EC:3.1.1.116]
128061601  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
128057648  ABHD6; monoacylglycerol lipase ABHD6 [KO:K13700] [EC:3.1.1.23]
128045162  FAAH; fatty-acid amide hydrolase 1 [KO:K15528] [EC:3.5.1.99]
128053464  CNR1; cannabinoid receptor 1 [KO:K04277]
128044413  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
128057155  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
128046449  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
128062941  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha [KO:K04534]
128061341  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
128068195  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
128047979  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
128050433  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
128054091  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
128068668  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
128048580  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
128046927  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
128043525  KCNJ3; G protein-activated inward rectifier potassium channel 1 [KO:K04997]
128053340  KCNJ6; G protein-activated inward rectifier potassium channel 2 [KO:K05000]
128045248  KCNJ9; G protein-activated inward rectifier potassium channel 3 [KO:K05002]
128069002  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
128050795  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
128055241  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128051495  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
128047244  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128049619  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
128047426  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
128048391  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
128055294  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
128055801  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
128046764  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
128066123  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
128056879  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
128053854  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
128067499  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
128047362  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
128063240  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
128059256  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
128043555  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
128050339  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
128044465  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
128049433  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
8250974  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
8250973  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
8250967  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
8250969  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
8250968  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
8250970  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
8250971  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
128068660  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
128058489  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
128067418  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
128045118  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
128050721  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
128063056  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
128046973  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
128046696  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
128048621  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
128046403  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
128048517  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
128051330  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
128056168  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
128047836  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
128044635  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
128043191  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
128051437  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
128048376  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
128051389  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
128066874  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
128046972  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
128067868  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 isoform X1 [KO:K03959]
128053787  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
128046653  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
128052403  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
128051202  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
128067819  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
128059268  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
128043200  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
128070595  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
128063561  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
128044487  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
128060120  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
128066111  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
128045154  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
128066127  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
128050799  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
128068819  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
128062454  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
128068963  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
128058797  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
128059103  RIMS1; regulating synaptic membrane exocytosis protein 1 [KO:K15291]
128069937  GABRA3; gamma-aminobutyric acid receptor subunit alpha-3 [KO:K05175]
128050737  GABRA6; gamma-aminobutyric acid receptor subunit alpha-6 [KO:K05175]
128050822  GABRA1; gamma-aminobutyric acid receptor subunit alpha-1 [KO:K05175]
128066560  GABRA5; gamma-aminobutyric acid receptor subunit alpha-5 [KO:K05175]
128049649  GABRA4; gamma-aminobutyric acid receptor subunit alpha-4 [KO:K05175]
128049711  GABRA2; gamma-aminobutyric acid receptor subunit alpha-2 [KO:K05175]
128051328  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 [KO:K05181]
128066802  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 [KO:K05181]
128049767  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 [KO:K05181]
128050701  GABRG2; gamma-aminobutyric acid receptor subunit gamma-2 [KO:K05186]
128066630  GABRG3; gamma-aminobutyric acid receptor subunit gamma-3 [KO:K05186]
128049695  GABRG1; gamma-aminobutyric acid receptor subunit gamma-1 [KO:K05186]
128061684  GABRD; gamma-aminobutyric acid receptor subunit delta [KO:K05184]
128070400  GABRE; gamma-aminobutyric acid receptor subunit epsilon [KO:K05185]
128070455  GABRQ; gamma-aminobutyric acid receptor subunit theta [KO:K05192]
128066188  GABRP; gamma-aminobutyric acid receptor subunit pi [KO:K05189]
128053315  GABRR2; gamma-aminobutyric acid receptor subunit rho-2 [KO:K05190]
128053350  GABRR1; gamma-aminobutyric acid receptor subunit rho-1 [KO:K05190]
128055352  GABRR3; gamma-aminobutyric acid receptor subunit rho-3 [KO:K05190]
Compound
C00025  L-Glutamate
C00076  Calcium cation
C00116  Glycerol
C00157  Phosphatidylcholine
C00165  Diacylglycerol
C00189  Ethanolamine
C00219  Arachidonate
C00238  Potassium cation
C00334  4-Aminobutanoate
C00350  Phosphatidylethanolamine
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00689  alpha,alpha'-Trehalose 6-phosphate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C11695  Anandamide
C13856  2-Arachidonoylglycerol
C19912  N-Arachidonoyl-phosphatidylethanolamine
C19913  Phospho-anandamide
Reference
PMID:17419048
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Ca(2+)-assisted receptor-driven endocannabinoid release: mechanisms that associate presynaptic and postsynaptic activities.
  Journal
Curr Opin Neurobiol 17:360-5 (2007)
DOI:10.1016/j.conb.2007.03.012
Reference
PMID:21531987
  Authors
Ohno-Shosaku T, Tanimura A, Hashimotodani Y, Kano M
  Title
Endocannabinoids and retrograde modulation of synaptic transmission.
  Journal
Neuroscientist 18:119-32 (2012)
DOI:10.1177/1073858410397377
Reference
PMID:18084639
  Authors
Basavarajappa BS
  Title
Neuropharmacology of the endocannabinoid signaling system-molecular mechanisms, biological actions and synaptic plasticity.
  Journal
Curr Neuropharmacol 5:81-97 (2007)
DOI:10.2174/157015907780866910
Reference
PMID:16968947
  Authors
Pacher P, Batkai S, Kunos G
  Title
The endocannabinoid system as an emerging target of pharmacotherapy.
  Journal
Pharmacol Rev 58:389-462 (2006)
DOI:10.1124/pr.58.3.2
Reference
PMID:15340387
  Authors
Di Marzo V, Bifulco M, De Petrocellis L
  Title
The endocannabinoid system and its therapeutic exploitation.
  Journal
Nat Rev Drug Discov 3:771-84 (2004)
DOI:10.1038/nrd1495
Reference
PMID:17404373
  Authors
Hashimotodani Y, Ohno-Shosaku T, Kano M
  Title
Endocannabinoids and synaptic function in the CNS.
  Journal
Neuroscientist 13:127-37 (2007)
DOI:10.1177/1073858406296716
Reference
PMID:19126760
  Authors
Kano M, Ohno-Shosaku T, Hashimotodani Y, Uchigashima M, Watanabe M
  Title
Endocannabinoid-mediated control of synaptic transmission.
  Journal
Physiol Rev 89:309-80 (2009)
DOI:10.1152/physrev.00019.2008
Reference
PMID:19640475
  Authors
Regehr WG, Carey MR, Best AR
  Title
Activity-dependent regulation of synapses by retrograde messengers.
  Journal
Neuron 63:154-70 (2009)
DOI:10.1016/j.neuron.2009.06.021
Reference
PMID:17636069
  Authors
Benarroch E
  Title
Endocannabinoids in basal ganglia circuits: implications for Parkinson disease.
  Journal
Neurology 69:306-9 (2007)
DOI:10.1212/01.wnl.0000267407.79757.75
Reference
PMID:16085309
  Authors
Ohno-Shosaku T, Hashimotodani Y, Maejima T, Kano M
  Title
Calcium signaling and synaptic modulation: regulation of endocannabinoid-mediated synaptic modulation by calcium.
  Journal
Cell Calcium 38:369-74 (2005)
DOI:10.1016/j.ceca.2005.06.014
Reference
PMID:18801434
  Authors
Harkany T, Mackie K, Doherty P
  Title
Wiring and firing neuronal networks: endocannabinoids take center stage.
  Journal
Curr Opin Neurobiol 18:338-45 (2008)
DOI:10.1016/j.conb.2008.08.007
Reference
PMID:18515270
  Authors
Hosking RD, Zajicek JP
  Title
Therapeutic potential of cannabis in pain medicine.
  Journal
Br J Anaesth 101:59-68 (2008)
DOI:10.1093/bja/aen119
Reference
PMID:21187849
  Authors
Di Marzo V
  Title
Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight.
  Journal
Nat Neurosci 14:9-15 (2011)
DOI:10.1038/nn.2720
Reference
PMID:18948642
  Authors
McPartland JM
  Title
The endocannabinoid system: an osteopathic perspective.
  Journal
J Am Osteopath Assoc 108:586-600 (2008)
DOI:10.7556/jaoa.2008.108.10.586
Reference
PMID:17553427
  Authors
Chevaleyre V, Heifets BD, Kaeser PS, Sudhof TC, Castillo PE
  Title
Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1alpha.
  Journal
Neuron 54:801-12 (2007)
DOI:10.1016/j.neuron.2007.05.020
Reference
PMID:19553483
  Authors
Lafourcade CA
  Title
Presynaptic mechanisms of endocannabinoid-mediated long-term depression in the hippocampus.
  Journal
J Neurophysiol 102:2009-12 (2009)
DOI:10.1152/jn.00441.2009
Reference
PMID:21328621
  Authors
Ueda N, Tsuboi K, Uyama T, Ohnishi T
  Title
Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.
  Journal
Biofactors 37:1-7 (2011)
DOI:10.1002/biof.131
Reference
PMID:14978245
  Authors
Guo J, Ikeda SR
  Title
Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons.
  Journal
Mol Pharmacol 65:665-74 (2004)
DOI:10.1124/mol.65.3.665
Reference
PMID:22388959
  Authors
Benard G, Massa F, Puente N, Lourenco J, Bellocchio L, Soria-Gomez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutierrez S, Martin-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, Lopez-Rodriguez ML, Grandes P, Rossignol R, Marsicano G
  Title
Mitochondrial CB(1) receptors regulate neuronal energy metabolism.
  Journal
Nat Neurosci 15:558-64 (2012)
DOI:10.1038/nn.3053
Reference
PMID:26260530
  Authors
Busquets-Garcia A, Desprez T, Metna-Laurent M, Bellocchio L, Marsicano G, Soria-Gomez E
  Title
Dissecting the cannabinergic control of behavior: The where matters.
  Journal
Bioessays 37:1215-25 (2015)
DOI:10.1002/bies.201500046
Reference
PMID:28076767
  Authors
Harkany T, Horvath TL
  Title
(S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity.
  Journal
Cell Metab 25:8-10 (2017)
DOI:10.1016/j.cmet.2016.12.020
Reference
PMID:22449955
  Authors
Alger BE, Tang AH
  Title
Do cannabinoids reduce brain power?
  Journal
Nat Neurosci 15:499-501 (2012)
DOI:10.1038/nn.3072
Related
pathway
btax00190  Oxidative phosphorylation
btax04020  Calcium signaling pathway
btax04721  Synaptic vesicle cycle
btax04724  Glutamatergic synapse
btax04727  GABAergic synapse
KO pathway
ko04723   
LinkDB

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