Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites (Q33837172)

29 July 2017

title

Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites (English)

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29 July 2017

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8

Ronald M Evans

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author name string

Junichiro Sonoda

1

1 reference

29 July 2017

Ling Wa Chong

2

1 reference

29 July 2017

Michael Downes

3

1 reference

29 July 2017

Grant D Barish

4

1 reference

29 July 2017

Sally Coulter

5

1 reference

29 July 2017

Christopher Liddle

6

1 reference

29 July 2017

Chih-Hao Lee

7

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29 July 2017

language of work or name

English

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publication date

25 January 2005

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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29 July 2017

volume

102

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29 July 2017

issue

6

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29 July 2017

page(s)

2198-2203

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A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.

29 July 2017

cites work

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4 July 2018

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Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance

4 July 2018

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4 July 2018

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Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

4 July 2018

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The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

4 July 2018

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Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

4 July 2018

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The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

4 July 2018

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Differences in hepatic levels of intermediates in bile acid biosynthesis between Cyp27(-/-) mice and CTX.

4 July 2018

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Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

4 July 2018

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The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

4 July 2018

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4 July 2018

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Human UDP-glucuronosyltransferases: metabolism, expression, and disease

4 July 2018

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The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

4 July 2018

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Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver

4 July 2018

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Features of Alagille syndrome in 92 patients: frequency and relation to prognosis

4 July 2018

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

4 July 2018

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Unexpected clinical remission of cholestasis after rifampicin therapy in patients with normal or slightly increased levels of gamma-glutamyl transpeptidase

4 July 2018

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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

4 July 2018

1 reference

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An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

4 July 2018

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Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites

4 July 2018

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Effects of long-term rifampicin administration in primary biliary cirrhosis

4 July 2018

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Hypercholesterolemia and atherosclerosis in primary biliary cirrhosis: what is the risk?

4 July 2018

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Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

4 July 2018

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Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

21 January 2018

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Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis.

21 January 2018

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CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor

21 January 2018

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Feed-forward regulation of bile acid detoxification by CYP3A4: studies in humanized transgenic mice

21 January 2018

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Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression.

21 January 2018

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A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

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The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

21 January 2018

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1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression

21 January 2018

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Resistance of SHP-null mice to bile acid-induced liver damage

21 January 2018

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Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

21 January 2018

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Bile system morphogenesis defects and liver dysfunction upon targeted deletion of HNF1beta.

21 January 2018

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Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=548561

Abnormal lipoprotein pattern in patients with Alagille syndrome depends on Icterus severity

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15671183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular mechanisms of cholestasis: causes and consequences of impaired bile formation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15671183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

INDUCTION OF GALLSTONES IN MICE BY FEEDING A CHOLESTEROL-CHOLIC ACID CONTAINING DIET

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15671183

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0409481102

1 reference

29 July 2017

0 references

1 reference

29 July 2017

1 reference