The complexity of p53 stabilization and activation (Q36443523)

14 August 2017

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title

The complexity of p53 stabilization and activation (English)

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14 August 2017

M F Lavin

1

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14 August 2017

N Gueven

series ordinal

2

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14 August 2017

publication date

1 June 2006

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Cell Death & Differentiation

14 August 2017

published in

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14 August 2017

volume

13

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14 August 2017

issue

6

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14 August 2017

page(s)

941-950

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On the road to cancer: aneuploidy and the mitotic checkpoint

14 August 2017

cites work

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7 January 2021

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P53 in cancer: a paradigm for modern management of cancer

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The p53 tumour suppressor gene

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7 January 2021

Role of p53 in sensing oxidative DNA damage in response to reactive oxygen species-generating agents

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7 January 2021

Cooperation between BRCA1 and p53 in repair of cyclobutane pyrimidine dimers

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7 January 2021

Regulation of p53 in response to DNA damage

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7 January 2021

The p53 pathway: positive and negative feedback loops

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7 January 2021

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

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7 January 2021

Hypoxia links ATR and p53 through replication arrest

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7 January 2021

p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells

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7 January 2021

Does the ribosome translate cancer?

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7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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7 January 2021

BRCA1 physically associates with p53 and stimulates its transcriptional activity.

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7 January 2021

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

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7 January 2021

Activation of p53 protein by telomeric (TTAGGG)n repeats

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7 January 2021

The p53 story: layers of complexity

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7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

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7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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7 January 2021

ATM associates with and phosphorylates p53: mapping the region of interaction

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7 January 2021

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

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7 January 2021

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

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7 January 2021

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

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7 January 2021

Reactivation of mutant p53: a new strategy for cancer therapy.

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7 January 2021

Recruitment of p300/CBP in p53-dependent signal pathways

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7 January 2021

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

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7 January 2021

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

P53 and PML: new partners in tumor suppression

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Why is p53 acetylated?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Identification and characterization of the IKKalpha promoter: positive and negative regulation by ETS-1 and p53, respectively

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Acetylation of p53 inhibits its ubiquitination by Mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Post-translational modifications and activation of p53 by genotoxic stresses

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Pinning a change on p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Interferon regulatory factor 1 binding to p300 stimulates DNA-dependent acetylation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53

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7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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7 January 2021

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

1 reference

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7 January 2021

p53-Mdm2--the affair that never ends

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7 January 2021

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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7 January 2021

ATM-dependent CHK2 activation induced by anticancer agent, irofulven

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7 January 2021

MDM2 interacts with MDMX through their RING finger domains

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

MdmX protects p53 from Mdm2-mediated degradation

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

DNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Cell cycle control, DNA damage checkpoints and cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Ataxia-telangiectasia: a multifaceted genetic disorder associated with defective signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

The two edges of the ATM sword: co-operation between repair and checkpoint functions

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Prognostic value of p53 mutations in patients with locally advanced esophageal carcinoma treated with definitive chemoradiotherapy

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

DNA damage-induced phosphorylation of p53 at serine 20 correlates with p21 and Mdm-2 induction in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

A dynamic role of HAUSP in the p53-Mdm2 pathway

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

p53 proteasomal degradation: poly-ubiquitination is not the whole story

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7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

A new effector pathway links ATM kinase with the DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Regulation of p53 activity through lysine methylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Nucleophosmin regulates the stability and transcriptional activity of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

HIPK2 neutralizes MDM2 inhibition rescuing p53 transcriptional activity and apoptotic function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Poly(ADP-ribose) polymerase-1 is a positive regulator of the p53-mediated G1 arrest response following ionizing radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401925

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401925

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14 August 2017

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