Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms (Q38151200)

29 August 2017

title

Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms (English)

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29 August 2017

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1

Rüdiger Hardeland

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29 August 2017

publication date

23 September 2013

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Journal of Pineal Research

29 August 2017

published in

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29 August 2017

volume

55

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29 August 2017

issue

4

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29 August 2017

page(s)

325-356

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Aging: a theory based on free radical and radiation chemistry

29 August 2017

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The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.

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Screening candidate longevity therapeutics using gene-expression arrays

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Improved mitochondrial function and increased life span after chronic melatonin treatment in senescent prone mice.

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The timing of the shrew: continuous melatonin treatment maintains youthful rhythmic activity in aging Crocidura russula

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Interactions between melatonin and estrogen may regulate cerebrovascular function in women: clinical implications for the effective use of HRT during menopause and aging

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Clinical uses of melatonin: evaluation of human trials

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Aging and vascular dysfunction: beneficial melatonin effects.

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Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor

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SASPense and DDRama in cancer and ageing.

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SASP reflects senescence.

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The senescence-associated secretory phenotype: the dark side of tumor suppression

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Toll like receptor signaling in "inflammaging": microRNA as new players.

21 January 2018

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MicroRNAs linking inflamm-aging, cellular senescence and cancer

21 January 2018

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Anti-inflammatory effect of ubiquinol-10 on young and senescent endothelial cells via miR-146a modulation

21 January 2018

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Neuroprotection by radical avoidance: search for suitable agents.

21 January 2018

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The immune system in extreme longevity

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Inflammation, genetic background and longevity

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Role of the immune system in aging and longevity

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Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency

21 January 2018

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Oxidative stress in vascular senescence: lessons from successfully aging species

21 January 2018

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Sirtuins in aging and disease

21 January 2018

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Tissue-specific regulation of SIRT1 by calorie restriction

21 January 2018

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The coordination of nuclear and mitochondrial communication during aging and calorie restriction

21 January 2018

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Effects of GH in human muscle and fat.

21 January 2018

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The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations

21 January 2018

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Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling

21 January 2018

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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

21 January 2018

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SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression

21 January 2018

1 reference

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

21 January 2018

1 reference

Calorie restriction and the nutrient sensing signaling pathways

21 January 2018

1 reference

Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues

21 January 2018

1 reference

Mitochondrial biogenesis and healthy aging

21 January 2018

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Resveratrol induces mitochondrial biogenesis in endothelial cells

21 January 2018

1 reference

The "rejuvenatory" impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha

21 January 2018

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Peroxisome proliferator-activated receptor-gamma-mediated positive energy balance in the rat is associated with reduced sympathetic drive to adipose tissues and thyroid status

21 January 2018

1 reference

Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes

21 January 2018

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Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents

21 January 2018

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Cognitive deficit in amyloid-beta-injected mice was improved by pretreatment with a low dose of telmisartan partly because of peroxisome proliferator-activated receptor-gamma activation

21 January 2018

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Molecules involve in the self-protection of neurons against glucose-oxygen-serum deprivation (GOSD)-induced cell damage

21 January 2018

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Effects of a single dose of methylprednisolone versus three doses of rosiglitazone on nerve growth factor levels after spinal cord injury

21 January 2018

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Telmisartan protects against cognitive decline via up-regulation of brain-derived neurotrophic factor/tropomyosin-related kinase B in hippocampus of hypertensive rats

21 January 2018

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PPARγ-mediated advanced glycation end products regulate neural stem cell proliferation but not neural differentiation through the BDNF-CREB pathway

21 January 2018

1 reference

Acute modulation of somatostatin receptor function by melatonin in the rat frontoparietal cortex.

21 January 2018

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Effect of oral administration of melatonin on GH responses to GRF 1-44 in normal subjects

21 January 2018

1 reference

Effects of a single dose of N-Acetyl-5-methoxytryptamine (Melatonin) and resistance exercise on the growth hormone/IGF-1 axis in young males and females

21 January 2018

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Phase-shifts of 24-h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men.

21 January 2018

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Circadian aspects of growth hormone-insulin-like growth factor axis function in patients with lung cancer.

21 January 2018

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A randomized controlled trial of oral melatonin supplementation and breast cancer biomarkers.

21 January 2018

1 reference

The role of melatonin in the pathogenesis of hypertension in rats with metabolic syndrome

21 January 2018

1 reference

Melatonin may curtail the metabolic syndrome: studies on initial and fully established fructose-induced metabolic syndrome in rats

21 January 2018

1 reference

Melatonin improves glucose homeostasis in young Zucker diabetic fatty rats

21 January 2018

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Melatonin prevents the development of the metabolic syndrome in male rats exposed to different light/dark regimens

21 January 2018

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Ramelteon attenuates age-associated hypertension and weight gain in spontaneously hypertensive rats.

21 January 2018

1 reference

NEU-P11, a novel melatonin agonist, inhibits weight gain and improves insulin sensitivity in high-fat/high-sucrose-fed rats.

21 January 2018

1 reference

Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling.

21 January 2018

1 reference

Melatonin and type 2 diabetes - a possible link?

21 January 2018

1 reference

Melatonin and the metabolic syndrome: physiopathologic and therapeutical implications

21 January 2018

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Melatonin and the metabolic syndrome: a tool for effective therapy in obesity-associated abnormalities?

21 January 2018

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Obesity and metabolic syndrome: association with chronodisruption, sleep deprivation, and melatonin suppression

21 January 2018

1 reference

Metabolic syndrome, its pathophysiology and the role of melatonin

21 January 2018

1 reference

Evaluation of potential pro-survival pathways regulated by melatonin in a murine senescence model

21 January 2018

1 reference

Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats

21 January 2018

1 reference

Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway.

21 January 2018

1 reference

SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms

21 January 2018

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Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

21 January 2018

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SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells

21 January 2018

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Molecular mechanisms of melatonin anticancer effects

21 January 2018

1 reference

Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway

21 January 2018

1 reference

The antiapoptotic activity of melatonin in neurodegenerative diseases

21 January 2018

1 reference

Melatonin reduces indomethacin-induced gastric mucosal cell apoptosis by preventing mitochondrial oxidative stress and the activation of mitochondrial pathway of apoptosis

21 January 2018

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Melatonin signaling and cell protection function

21 January 2018

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Melatonin attenuates apoptotic liver damage in fulminant hepatic failure induced by the rabbit hemorrhagic disease virus

21 January 2018

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Melatonin protects against apoptotic and autophagic cell death in C2C12 murine myoblast cells

21 January 2018

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Melatonin: the smart killer: the human trophoblast as a model

21 January 2018

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Melatonin may play a role in modulation of bax and bcl-2 expression levels to protect rat peripheral blood lymphocytes from gamma irradiation-induced apoptosis.

21 January 2018

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Melatonin induces mitochondrial-mediated apoptosis in human myeloid HL-60 cells

21 January 2018

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Basic Mechanisms Involved in the Anti-Cancer Effects of Melatonin

21 January 2018

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In vitro and in vivo antitumor activity of melatonin receptor agonists

21 January 2018

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Melatonin, a natural programmed cell death inducer in cancer

21 January 2018

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Mechanisms involved in the pro-apoptotic effect of melatonin in cancer cells

21 January 2018

1 reference

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

21 January 2018

1 reference

SIRT1 is a circadian deacetylase for core clock components

21 January 2018

1 reference

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

21 January 2018

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Chromatin remodeling, metabolism and circadian clocks: the interplay of CLOCK and SIRT1.

21 January 2018

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Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1

21 January 2018

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Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

21 January 2018

1 reference

Circadian rhythms. A circadian loop asSIRTs itself

21 January 2018

1 reference

Impact of aging on diurnal expression patterns of CLOCK and BMAL1 in the mouse brain

21 January 2018

1 reference

Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1.

21 January 2018

1 reference

The aging clock: to 'BMAL'icious toward learning and memory

21 January 2018

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Deficiency in core circadian protein Bmal1 is associated with a prothrombotic and vascular phenotype

21 January 2018

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Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

21 January 2018

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Early aging and age-related pathologies in mice deficient in BMAL1, the core componentof the circadian clock

21 January 2018

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Deficiency of circadian protein CLOCK reduces lifespan and increases age-related cataract development in mice

21 January 2018

1 reference

Melatonin stimulates glucose transport via insulin receptor substrate-1/phosphatidylinositol 3-kinase pathway in C2C12 murine skeletal muscle cells

21 January 2018

1 reference

Melatonin ameliorates high fat diet-induced diabetes and stimulates glycogen synthesis via a PKCzeta-Akt-GSK3beta pathway in hepatic cells

21 January 2018

1 reference

Melatonin-mediated insulin synthesis during endoplasmic reticulum stress involves HuD expression in rat insulinoma INS-1E cells

21 January 2018

1 reference

Melatonin Potentiates the Neuroprotective Properties of Resveratrol Against Beta-Amyloid-Induced Neurodegeneration by Modulating AMP-Activated Protein Kinase Pathways

21 January 2018

1 reference

Adaptations of the aging animal to exercise: role of daily supplementation with melatonin.

21 January 2018

1 reference

The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?

21 January 2018

1 reference

Deacetylation of PGC-1α by SIRT1: importance for skeletal muscle function and exercise-induced mitochondrial biogenesis

21 January 2018

1 reference

Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3.

21 January 2018

1 reference

Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas

21 January 2018

1 reference

LKB1 downregulation may be independent of promoter methylation or FOXO3 expression in head and neck cancer.

21 January 2018

1 reference

Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinson's Disease

21 January 2018

1 reference

A defect in the activity of Delta6 and Delta5 desaturases may be a factor predisposing to the development of insulin resistance syndrome

21 January 2018

1 reference

Feeding cues alter clock gene oscillations and photic responses in the suprachiasmatic nuclei of mice exposed to a light/dark cycle.

21 January 2018

1 reference

Calorie restriction reduces pinealectomy-induced insulin resistance by improving GLUT4 gene expression and its translocation to the plasma membrane

21 January 2018

1 reference

Calorie restriction in rhesus monkeys

21 January 2018

1 reference

Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways.

21 January 2018

1 reference

Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression.

21 January 2018

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Adipocyte differentiation is inhibited by melatonin through the regulation of C/EBPbeta transcriptional activity

21 January 2018

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Melatonin promotes differentiation of 3T3-L1 fibroblasts.

21 January 2018

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Melatonin: signaling mechanisms of a pleiotropic agent

21 January 2018

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Melatonin induces histone hyperacetylation in the rat brain

21 January 2018

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Melatonin reverses tunicamycin-induced endoplasmic reticulum stress in human hepatocellular carcinoma cells and improves cytotoxic response to doxorubicin by increasing CHOP and decreasing survivin

21 January 2018

1 reference

Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras.

21 January 2018

1 reference

Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-κB and STAT/GAS activity

21 January 2018

1 reference

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells

21 January 2018

1 reference

Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors

21 January 2018

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Melatonin Induces Akt Phosphorylation through Melatonin Receptor- and PI3K-Dependent Pathways in Primary Astrocytes

21 January 2018

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Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats.

21 January 2018

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Sustained activation of Akt by melatonin contributes to the protection against kainic acid-induced neuronal death in hippocampus

21 January 2018

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Melatonin prevents the injury-induced decline of Akt/forkhead transcription factors phosphorylation

21 January 2018

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Effects of memantine and melatonin on signal transduction pathways vascular leakage and brain injury after focal cerebral ischemia in mice

21 January 2018

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Signal transduction pathways involved in melatonin-induced neuroprotection after focal cerebral ischemia in mice

21 January 2018

1 reference

Tissue-plasminogen activator-induced ischemic brain injury is reversed by melatonin: role of iNOS and Akt.

21 January 2018

1 reference

The role of melatonin as an antioxidant in human lens epithelial cells

21 January 2018

1 reference

Melatonin enhances leptin expression by rat adipocytes in the presence of insulin.

21 January 2018

1 reference

Melatonin-mediated cytoprotection against hyperglycemic injury in Müller cells

21 January 2018

1 reference

Melatonin improves glucose homeostasis and endothelial vascular function in high-fat diet-fed insulin-resistant mice

21 January 2018

1 reference

Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions.

21 January 2018

1 reference

Mitochondrial nucleoid and transcription factor A.

21 January 2018

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Mitochondrial transcription factor A regulates mtDNA copy number in mammals

21 January 2018

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Mitochondrial transcription factor A in the maintenance of mitochondrial DNA: overview of its multiple roles

21 January 2018

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Association of mitochondrial antioxidant enzymes with mitochondrial DNA as integral nucleoid constituents

21 January 2018

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The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

21 January 2018

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Oxidative stress, mitochondria and mtDNA-mutator mice

21 January 2018

1 reference

Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance

21 January 2018

1 reference

The role of mitochondrial nitric oxide synthase in inflammation and septic shock

21 January 2018

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Pharmacological utility of melatonin in the treatment of septic shock: experimental and clinical evidence

21 January 2018

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Nitric oxide and oxygen metabolism in inflammatory conditions: sepsis and exposition to polluted ambients

21 January 2018

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Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria

21 January 2018

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Persistent S-nitrosation of complex I and other mitochondrial membrane proteins by S-nitrosothiols but not nitric oxide or peroxynitrite: implications for the interaction of nitric oxide with mitochondria

21 January 2018

1 reference

Peroxynitrite reactions and formation in mitochondria

21 January 2018

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Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid

21 January 2018

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Chemical biology of peroxynitrite: kinetics, diffusion, and radicals.

21 January 2018

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Cardiolipin as an oxidative target in cardiac mitochondria in the aged rat

21 January 2018

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Enhanced modification of cardiolipin during ischemia in the aged heart

21 January 2018

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Role of phospholipids in respiratory cytochrome bc(1) complex catalysis and supercomplex formation

21 January 2018

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Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin

21 January 2018

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Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome C and turning on the peroxidase activity

21 January 2018

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Mitochondria, oxidative stress and cell death

21 January 2018

1 reference

Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis

21 January 2018

1 reference

Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery

21 January 2018

1 reference

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

21 January 2018

1 reference

Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation

21 January 2018

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Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

21 January 2018

1 reference

Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia- reperfusion: role of cardiolipin.

21 January 2018

1 reference

Melatonin reduces early changes in intramitochondrial cardiolipin during apoptosis in U937 cell line

21 January 2018

1 reference

Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protection

21 January 2018

1 reference

mtDNA T8993G mutation-induced mitochondrial complex V inhibition augments cardiolipin-dependent alterations in mitochondrial dynamics during oxidative, Ca(2+), and lipid insults in NARP cybrids: a potential therapeutic target for melatonin

21 January 2018

1 reference

Melatonin protects fetal rat brain against oxidative mitochondrial damage

21 January 2018

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Free Radical-Mediated Molecular Damage

21 January 2018

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Protective effect of melatonin against mitochondrial injury induced by ischemia and reperfusion of rat liver

21 January 2018

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Melatonin role in the mitochondrial function.

21 January 2018

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Melatonin reduces oxidant damage and promotes mitochondrial respiration: implications for aging

21 January 2018

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Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice.

21 January 2018

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Glutathione peroxidase 4 differentially regulates the release of apoptogenic proteins from mitochondria

21 January 2018

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Substrate and functional diversity of lysine acetylation revealed by a proteomics survey

21 January 2018

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Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5

21 January 2018

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Mitochondrial superoxide radical formation is controlled by electron bifurcation to the high and low potential pathways

21 January 2018

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Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide, but not by glycerol trinitrate

21 January 2018

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Superoxide flashes in single mitochondria

21 January 2018

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Superoxide flashes: illuminating new insights into cardiac ischemia/reperfusion injury

21 January 2018

1 reference

Melatonin preserves the transient mitochondrial permeability transition for protection during mitochondrial Ca(2+) stress in astrocyte

21 January 2018

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Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca(2+)-mediated permeability transition and beyond in rat brain astrocytes

21 January 2018

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Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production

21 January 2018

1 reference

Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease

21 January 2018

1 reference

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

21 January 2018

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Tissue retention and subcellular distribution of continuously infused melatonin in rats under near physiological conditions

21 January 2018

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Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450.

21 January 2018

1 reference

Mitochondrial respiratory chain and thioredoxin reductase regulate intermembrane Cu,Zn-superoxide dismutase activity: implications for mitochondrial energy metabolism and apoptosis

21 January 2018

1 reference

Effect of melatonin treatment on oxygen consumption by rat liver mitochondria

21 January 2018

1 reference

Mitochondria as targets for nitric oxide-induced protection during simulated ischemia and reoxygenation in isolated neonatal cardiomyocytes

21 January 2018

1 reference

Melatonin, mitochondrial homeostasis and mitochondrial-related diseases

21 January 2018

1 reference

Melatonin combats molecular terrorism at the mitochondrial level

21 January 2018

1 reference

The role of mitochondria in brain aging and the effects of melatonin

21 January 2018

1 reference

Melatonin in mitochondrial dysfunction and related disorders

21 January 2018

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Melatonin-mitochondria interplay in health and disease.

21 January 2018

1 reference

Melatonin and mitochondrial dysfunction in the central nervous system

21 January 2018

1 reference

Decreased mitochondrial DNA copy number in the hippocampus and peripheral blood during opiate addiction is mediated by autophagy and can be salvaged by melatonin

21 January 2018

1 reference

Melatonin attenuates kainic acid-induced neurotoxicity in mouse hippocampus via inhibition of autophagy and α-synuclein aggregation.

21 January 2018

1 reference

Evidence of prooxidant and antioxidant action of melatonin on human liver cell line HepG2.

21 January 2018

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Does melatonin induce apoptosis in MCF-7 human breast cancer cells in vitro?

21 January 2018

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Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line

21 January 2018

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Evidence for a biphasic apoptotic pathway induced by melatonin in MCF-7 breast cancer cells.

21 January 2018

1 reference

Melatonin reduces pancreatic tumor cell viability by altering mitochondrial physiology

21 January 2018

1 reference

Pro-oxidant effect of melatonin in tumour leucocytes: relation with its cytotoxic and pro-apoptotic effects

21 January 2018

1 reference

A Comparison of B16 Melanoma Cells and 3T3 Fibroblasts Concerning Cell Viability and ROS Production in the Presence of Melatonin, Tested Over a Wide Range of Concentrations

21 January 2018

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Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells

21 January 2018

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The role of mitochondrial complex III in melatonin‐induced ROS production in cultured mesangial cells

21 January 2018

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Mitochondrial decay in aging

21 January 2018

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The role of mitochondria in aging of skeletal muscle

21 January 2018

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Aging selectively decreases oxidative capacity in rat heart interfibrillar mitochondria

21 January 2018

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Interfibrillar cardiac mitochondrial comples III defects in the aging rat heart

21 January 2018

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Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria.

21 January 2018

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Aging defect at the QO site of complex III augments oxyradical production in rat heart interfibrillar mitochondria

21 January 2018

1 reference

Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatonin

21 January 2018

1 reference

21 January 2018

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Melatonin in Alzheimer's disease and other neurodegenerative disorders

21 January 2018

1 reference

Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling

21 January 2018

1 reference

Accumulation of exogenous amyloid-beta peptide in hippocampal mitochondria causes their dysfunction: a protective role for melatonin

21 January 2018

1 reference

Comparative studies of early liver dysfunction in senescence-accelerated mouse using mitochondrial proteomics approaches

21 January 2018

1 reference

Acutely administered melatonin restores hepatic mitochondrial physiology in old mice

21 January 2018

1 reference

An early stage mechanism of the age-associated mitochondrial dysfunction in the brain of SAMP8 mice; an age-associated neurodegeneration animal model

21 January 2018

1 reference

21 January 2018

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Brain mitochondrial dysfunction in aging

21 January 2018

1 reference

Neurochemistry, neuropathology, and heredity in SAMP8: a mouse model of senescence

21 January 2018

1 reference

Long-term melatonin administration protects brain mitochondria from aging.

21 January 2018

1 reference

Melatonin protects hepatic mitochondrial respiratory chain activity in senescence-accelerated mice

21 January 2018

1 reference

Hepatic mitochondrial dysfunction in senescence-accelerated mice: correction by long-term, orally administered physiological levels of melatonin

21 January 2018

1 reference

Melatonin protects lung mitochondria from aging

21 January 2018

1 reference

Melatonin reduces membrane rigidity and oxidative damage in the brain of SAMP8 mice.

21 January 2018

1 reference

Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol.

21 January 2018

1 reference

Melatonin can improve insulin resistance and aging-induced pancreas alterations in senescence-accelerated prone male mice (SAMP8).

21 January 2018

1 reference

Effects of antioxidants on immune system ageing

21 January 2018

1 reference

Centenarians as a model for healthy aging

21 January 2018

1 reference

Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity

21 January 2018

1 reference

No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study

21 January 2018

1 reference

Aging and immune function: molecular mechanisms to interventions

21 January 2018

1 reference

Can the immune system still be efficient in the elderly? An immunological and immunoendocrine therapeutic perspective

21 January 2018

1 reference

B cells compartment in centenarian offspring and old people.

21 January 2018

1 reference

Successful immunosenescence and the remodelling of immune responses with ageing

21 January 2018

1 reference

T cell homeostasis in centenarians: from the thymus to the periphery.

21 January 2018

1 reference

Immunosenescence of human natural killer cells

21 January 2018

1 reference

Zinc-bound metallothioneins and immune plasticity: lessons from very old mice and humans.

21 January 2018

1 reference

NK and NKT cells in aging and longevity: role of zinc and metallothioneins

21 January 2018

1 reference

Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans.

21 January 2018

1 reference

Melatonin-immune system relationships

21 January 2018

1 reference

A Review of the Multiple Actions of Melatonin on the Immune System

21 January 2018

1 reference

Melatonin and the immune system in aging.

21 January 2018

1 reference

Melatonin: buffering the immune system

21 January 2018

1 reference

A novel interplay between membrane and nuclear melatonin receptors in human lymphocytes: significance in IL-2 production

21 January 2018

1 reference

Effect of superior cervical ganglionectomy on 24-h variations in hormone secretion from the anterior hypophysis and in hypothalamic monoamine turnover during the preclinical phase of Freund's adjuvant arthritis in rats

21 January 2018

1 reference

Melatonin provides signal 3 to unprimed CD4(+) T cells but failed to stimulate LPS primed B cells

21 January 2018

1 reference

Regulation of T-cell-independent and T-cell-dependent antibody production by circadian rhythm and melatonin.

21 January 2018

1 reference

Pineal indoles stimulate the gene expression of immunomodulating cytokines

21 January 2018

1 reference

Melatonin receptor subtype MT2 (Mel 1b) and not mt1 (Mel 1a) is associated with melatonin-induced enhancement of cell-mediated and humoral immunity

21 January 2018

1 reference

Trade-off between L-thyroxin and melatonin in immune regulation of the Indian palm squirrel, Funambulus pennanti during the reproductively inactive phase

21 January 2018

1 reference

Melatonin membrane receptor type MT1 modulates cell-mediated immunity in the seasonally breeding tropical rodent Funambulus pennanti.

21 January 2018

1 reference

Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats

21 January 2018

1 reference

Effect of melatonin on neuroinflammation and acetylcholinesterase activity induced by LPS in rat brain

21 January 2018

1 reference

Melatonin counteracts inducible mitochondrial nitric oxide synthase-dependent mitochondrial dysfunction in skeletal muscle of septic mice.

21 January 2018

1 reference

Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice: its relation with mitochondrial dysfunction and prevention by melatonin.

21 January 2018

1 reference

Effect of melatonin on healing of colonic anastomosis in a rat model of peritonitis

21 January 2018

1 reference

Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages

21 January 2018

1 reference

Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding

21 January 2018

1 reference

Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats

21 January 2018

1 reference

Modification of nitric oxide synthase activity and neuronal response in rat striatum by melatonin and kynurenine derivatives

21 January 2018

1 reference

Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin

21 January 2018

1 reference

Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin

21 January 2018

1 reference

Nanomolar melatonin enhances nNOS expression and controls HaCaT-cells bioenergetics

21 January 2018

1 reference

New evidence for cross talk between melatonin and mitochondria mediated by a circadian-compatible interaction with nitric oxide

21 January 2018

1 reference

Circadian rhythms, oxidative stress, and antioxidative defense mechanisms

21 January 2018

1 reference

Intracellular prooxidant activity of melatonin induces a survival pathway involving NF-kappaB activation.

21 January 2018

1 reference

Rapid and transient stimulation of intracellular reactive oxygen species by melatonin in normal and tumor leukocytes.

21 January 2018

1 reference

Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2/interleukin-2 receptor system.

21 January 2018

1 reference

Melatonin synthesized by Jurkat human leukemic T cell line is implicated in IL-2 production.

21 January 2018

1 reference

Melatonin modulation of lymphocyte proliferation and Th1/Th2 cytokine expression

21 January 2018

1 reference

Melatonin enhances Th2 cell mediated immune responses: lack of sensitivity to reversal by naltrexone or benzodiazepine receptor antagonists

21 January 2018

1 reference

The orphan receptor family RZR/ROR, melatonin and 5-lipoxygenase: an unexpected relationship

21 January 2018

1 reference

The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes.

21 January 2018

1 reference

Lipoxygenase-mediated pro-radical effect of melatonin via stimulation of arachidonic acid metabolism.

21 January 2018

1 reference

Melatonin: a pleiotropic molecule regulating inflammation

21 January 2018

1 reference

Senescent cells as a source of inflammatory factors for tumor progression

21 January 2018

1 reference

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

21 January 2018

1 reference

Amyloid-beta oligomers set fire to inflammasomes and induce Alzheimer's pathology

21 January 2018

1 reference

Neuroinflammation and ageing: current theories and an overview of the data

21 January 2018

1 reference

Does melatonin play a disease-promoting role in rheumatoid arthritis?

21 January 2018

1 reference

Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro-inflammatory damage

21 January 2018

1 reference

Modulation of immunity in young-adult and aged squirrel, Funambulus pennanti by melatonin and p-chlorophenylalanine

21 January 2018

1 reference

Age dependent expression of melatonin membrane receptor (MT1, MT2) and its role in regulation of nitrosative stress in tropical rodent Funambulus pennanti.

21 January 2018

1 reference

Melatonin improves inflammation processes in liver of senescence-accelerated prone male mice (SAMP8)

21 January 2018

1 reference

Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging

21 January 2018

1 reference

From clock genes to telomeres in the regulation of the healthspan

21 January 2018

1 reference

Telomeres and immunological diseases of aging

21 January 2018

1 reference

The role of telomere shortening in somatic stem cells and tissue aging: lessons from telomerase model systems

21 January 2018

1 reference

Protective effect of melatonin on bone marrow mesenchymal stem cells against hydrogen peroxide-induced apoptosis in vitro

21 January 2018

1 reference

Effect of melatonin on mRNA expressions of transcription factors in murine embryonic stem cells

21 January 2018

1 reference

Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system

21 January 2018

1 reference

Melatonin modulates cell survival of new neurons in the hippocampus of adult mice.

21 January 2018

1 reference

Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice

21 January 2018

1 reference

Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro.

21 January 2018

1 reference

Melatonin increases proliferation of cultured neural stem cells obtained from adult mouse subventricular zone

21 January 2018

1 reference

Melatonin regulates the viability and differentiation of rat midbrain neural stem cells

21 January 2018

1 reference

Melatonin restores muscle regeneration and enhances muscle function after crush injury in rats.

21 January 2018

1 reference

Melatonin improves the reprogramming efficiency of murine-induced pluripotent stem cells using a secondary inducible system

21 January 2018

1 reference

Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade.

21 January 2018

1 reference

Melatonin inhibits fatty acid-induced triglyceride accumulation in ROS17/2.8 cells: implications for osteoblast differentiation and osteoporosis.

21 January 2018

1 reference

Melatonin and the skeleton.

21 January 2018

1 reference

Melatonin mediates protective effects on inflammatory response induced by interleukin-1 beta in human mesenchymal stem cells

21 January 2018

1 reference

Effects of melatonin on the proliferation and differentiation of rat adipose-derived stem cells.

21 January 2018

1 reference

Melatonin interferes in the desmoplastic reaction in breast cancer by regulating cytokine production

21 January 2018

1 reference

Melatonin: a clock-output, a clock-input

21 January 2018

1 reference

Melatonin rhythmicity: effect of age and Alzheimer's disease

21 January 2018

1 reference

Role of melatonin in neurodegenerative diseases

21 January 2018

1 reference

Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock".

21 January 2018

1 reference

Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease

21 January 2018

1 reference

The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo

21 January 2018

1 reference

Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia

21 January 2018

1 reference

Tumor suppression and circadian function

21 January 2018

1 reference

Period 2 mutation accelerates ApcMin/+ tumorigenesis

21 January 2018

1 reference

Circadian time-dependent tumor suppressor function of period genes

21 January 2018

1 reference

Metabolism and cancer: the circadian clock connection

21 January 2018

1 reference

Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice

21 January 2018

1 reference

Circadian control of the immune system

21 January 2018

1 reference

Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha.

21 January 2018

1 reference

TNF-α modulates expression of the circadian clock gene Per2 in rheumatoid synovial cells

21 January 2018

1 reference

SIRT1 as a therapeutic target in inflammaging of the pulmonary disease

21 January 2018

1 reference

Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence

21 January 2018

1 reference

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

21 January 2018

1 reference

(Re-)activation of neurons in aging and dementia: lessons from the hypothalamus

21 January 2018

1 reference

The suprachiasmatic nucleus is a functionally heterogeneous timekeeping organ.

21 January 2018

1 reference

Daily electrical silencing in the mammalian circadian clock.

21 January 2018

1 reference

Immunocytochemical demonstration of day/night changes of clock gene protein levels in the murine adrenal gland: differences between melatonin-proficient (C3H) and melatonin-deficient (C57BL) mice

21 January 2018

1 reference

Melatonin, aging, and age-related diseases: perspectives for prevention, intervention, and therapy

21 January 2018

1 reference

Redox-linked protonation state changes in cytochrome bc1 identified by Poisson–Boltzmann electrostatics calculations

21 January 2018

1 reference

Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JPI.12090

1 reference

29 August 2017

1 reference