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ONTOLOGY REPORT - ANNOTATIONS

Term:histone H4K20 methyltransferase activity
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Accession:GO:0042799 term browser browse the term
Definition:Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein.
Comment:Note that in some species, the methyl group may be added to a lysine in a slightly different position of the histone H4 protein, but that this term still applies.
Synonyms:exact_synonym: histone H4 lysine 20-specific methyltransferase activity;   histone H4K20 methylase activity;   histone H4K20 methylation;   histone lysine N-methyltransferase activity (H4-K20 specific);   histone methylase activity (H4-K20 specific);   histone methyltransferase activity (H4-K20 specific)
 xref: reactome:R-HSA-2301205 "SETD8 monomethylates histone H4";   reactome:R-HSA-5682965 "WHSC1 dimethylates histone H4 on lysine K21 at DSBs"


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histone H4K20 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07010705.1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 2:142,289,467...142,290,623 JBrowse link
G AABR07033047.1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr11:3,479,411...3,480,543 JBrowse link
G ENSRNOG00000067141 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr10:31,086,733...31,087,921 JBrowse link
G Kmt5a lysine methyltransferase 5A enables ISO
IBA		 (PMID:27338793)
GO_REF:0000033		 RGD
GO_Central		 PMID:27338793 GO_REF:0000033 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711 		JBrowse link
G Kmt5al2 lysine methyltransferase 5A like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:92,178,344...92,180,517
Ensembl chr  X:92,178,016...92,179,731 		JBrowse link
G Kmt5b lysine methyltransferase 5B enables ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:15145825), (PMID:24049080)
GO_REF:0000033
GO_REF:0000117
(PMID:24396869), (PMID:28114273)		 UniProt
RGD
GO_Central		 PMID:15145825 PMID:24049080 PMID:24396869 PMID:28114273 GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819 		JBrowse link
G Kmt5c lysine methyltransferase 5C enables ISO
IBA
ISS		 (PMID:24049080), (PMID:24396869), (PMID:28114273)
(PMID:15145825), (PMID:25335925)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:15145825 PMID:24049080 PMID:24396869 PMID:25335925 PMID:28114273 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145 		JBrowse link
G Nsd1 nuclear receptor binding SET domain protein 1 enables ISO (PMID:12805229) RGD PMID:12805229 NCBI chr17:9,311,963...9,426,373
Ensembl chr17:9,315,237...9,425,358 		JBrowse link
G Setd4 SET domain containing 4 enables ISO (PMID:31308046) RGD PMID:31308046 NCBI chr11:32,829,509...32,859,162
Ensembl chr11:32,838,063...32,858,243 		JBrowse link
G Smyd5 SMYD family member 5 enables IBA
ISO		 GO_REF:0000033
(PMID:22921934), (PMID:28250819)		 GO_Central
RGD		 PMID:22921934 PMID:28250819 GO_REF:0000033 NCBI chr 4:117,969,615...117,984,082
Ensembl chr 4:117,969,626...117,984,347 		JBrowse link
histone H4K20 monomethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07010705.1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 Ensembl chr 2:142,289,467...142,290,623 JBrowse link
G AABR07033047.1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 Ensembl chr11:3,479,411...3,480,543 JBrowse link
G Kmt5a lysine methyltransferase 5A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711 		JBrowse link
G Kmt5al2 lysine methyltransferase 5A like 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:92,178,344...92,180,517
Ensembl chr  X:92,178,016...92,179,731 		JBrowse link
G Kmt5b lysine methyltransferase 5B enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819 		JBrowse link
G Kmt5c lysine methyltransferase 5C enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145 		JBrowse link
G Prdm9 PR/SET domain 9 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652 		JBrowse link
histone H4K20 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll12 tubulin tyrosine ligase like 12 NOT|enables ISO (PMID:23251473) RGD PMID:23251473 NCBI chr 7:114,731,890...114,751,237
Ensembl chr 7:114,731,892...114,751,356 		JBrowse link
histone H4K20me methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmt5b lysine methyltransferase 5B enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819 		JBrowse link
G Kmt5c lysine methyltransferase 5C enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145 		JBrowse link
G Prdm9 PR/SET domain 9 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20627
    catalytic activity 6029
      catalytic activity, acting on a protein 2508
        protein methyltransferase activity 104
          protein-lysine N-methyltransferase activity 69
            histone H4K20 methyltransferase activity 12
              histone H4K20 monomethyltransferase activity 7
              histone H4K20 trimethyltransferase activity 1
              histone H4K20me methyltransferase activity 3
Path 2
Term Annotations click to browse term
  molecular_function 20627
    catalytic activity 6029
      transferase activity 2396
        transferase activity, transferring one-carbon groups 213
          methyltransferase activity 203
            S-adenosylmethionine-dependent methyltransferase activity 169
              lysine N-methyltransferase activity 69
                protein-lysine N-methyltransferase activity 69
                  histone H4K20 methyltransferase activity 12
                    histone H4K20 monomethyltransferase activity 7
                    histone H4K20 trimethyltransferase activity 1
                    histone H4K20me methyltransferase activity 3
paths to the root