Research Labs

Investigates the molecular mechanisms shaping hair cell architecture in the inner ear

Mark Adams leads the Genome Technologies Scientific Service and the Advanced Precision Medicine Laboratory which provide NGS capabilities for research and clinical applications. He also leads the NHGRI-funded Technology Development Coordinating Center. His research involves development of methods to target complex genome features including structural variation and gene expression.

The Agoro lab uses systems biology approaches to determine how iron-driven kidney oxidative stress influences FGF23-mediated phosphate excretion in aging, chronic kidney disease and sickle cell anemia.

Investigates how alternative RNA splicing contributes to cancer with the goal of identifying novel clinical biomarkers and targets for precision medicine.

Functional genomics and epigenetic modification

The Beck lab uses genomics, bioinformatics and molecular biological techniques to investigate the ways in which repetitive DNA elements, such as transposons, affect human genomes.

The Bloss Lab leverages high resolution imaging, observation and manipulation of in vivo neural activity, and genetic perturbations in specific neurons to define how neural circuits supports goal-directed behavior.

Researching meiosis, the mechanisms of DNA damage detection and repair during normal development of gametes, and implications for fertility of cancer patients after radiation and chemotherapy.

Investigating gamete development with a focus on spermatogenesis.

Bridging the digital biology divide, integrating computation with biomedical research.

Studies synapse development and function relevant to human neuromuscular disorders.

Developing new computational strategies to understand complex genetic systems.

The Chang Lab delves into the intricate realm of immune cell metabolism and its profound impact on diseases like cancer and lupus, forging effective treatments through in-depth molecular understanding.

Researches the genetics underlying behavior and identifies relationships among behavioral traits.

Analyzing sequence and assay data to better understand genome function.

Investigating the genetics of health and disease with a systems approach.

Researching the mechanisms that generate genetic diversity through the lens of evolution.

Utilizing genomic approaches to interrogate mechanisms of inherited cardiovascular disorders.

Investigates the early stages of age-related neurodegenerative diseases.

The Jalili Research Group at The Jackson Laboratory (JAX) is focused on interrogating the host immunity, microbiome and their interface using different engineering tools in the context of infectious diseases, autoimmunity and cancer.

The Joy Lab is interested in understanding how circuits in the brain rewire after a stroke and other CNS injuries, with the goal of identifying molecular and circuit principles for recovery.

Studies the genetics of kidney function and disease, particularly in the context of aging.

We are a group of geneticists, neuroscientists, and computer scientists who are passionate about discoveries of novel targets and models for mental illness through innovation at the confluence of computational, genetic, and genomic methods.

Using genomic technologies and mouse modeling including patient-derived xenografts (PDX) and genetically engineered mouse models (GEMM), we are discovering and validating novel biomarkers and therapeutic targets of pediatric cancers

The Lee Lab studies structural genomic variation in human biology, evolution and disease.

Researching the fundamental genomics of breast cancer.

Steven Munger, Ph.D., uses a systems genetics approach and advanced computational methods to study development and complex disease in advanced mouse populations.

Investigating the genetic mechanisms of craniofacial development and developing new genetic tools and resources for the scientific community.

Investigates the genetics of metabolic syndrome and ciliopathies.

Employs mouse models of human eye disease to study gene function and mechanisms underlying disease pathology.

The overarching goal of my NIH-funded research program is to understand the neural control of appetite and how diet and body weight affect the excitability of the neurons in key CNS circuits responsible for food intake.

Studying the mechanisms of human immunity and developing cancer immunotherapies.

Members of the Paust laboratory are interested in the development and testing of novel immunotherapies that elicit clinically relevant Natural Killer cell-mediated anti-pathogen or anti-tumor immunity.

Human pluripotent stem cells and the human embryo: Human pluripotent stem cells (hPSC) have opened up a previously inaccessible phase of the human life cycle to experimental study.

Dr. Reinholdt’s research focuses on comparative and functional mammalian genomics, reproductive development and stem cell biology.

To study tumor microenvironment and tumor immunology in cancer therapeutic resistance and metastatic relapse

Captures gene expression data and disseminates it to the research community.

Develops algorithms and software for the analysis of exome and genome sequences.

The Robson lab utilizes advanced molecular, cellular, and stem cell biology approaches to study evolution, development, and disease relevant to the human condition.

Investigating the role of growth factors, stem cells and the immune system in cardiovascular and skeletal muscle disease and regeneration.

The overall focus of my research program has been to understand the molecular and cellular mechanisms underlying tissue growth and tissue regeneration with the long-term goal of developing new strategies for treating human diseases.

Investigating the genetic basis of autoimmunity and type 1 diabetes.

Investigates human immunological diseases and malignancy through the development and leveraging of novel humanized mouse models

The application of high-resolution mass spectrometry now enables the measurement in human samples the metabolome, lipidome and small molecules of dietary, microbial and environmental origins.

Researches human pancreatic islet cells and the genetic and environmental bases of type 2 diabetes.

Our lab is focused on identifying and understanding the precise genetic mechanisms influencing human complex traits and risk to disease. To accomplish this our work spans several areas of interest.

Researches regulation of stem cells in the blood in normal development, aging and leukemia transformation.

Develops computational methods to study the epigenetic regulation of gene expression and its implications in important human conditions including aging and common diseases.

The Unutmaz Lab investigates the biology of the human immune system.

Integrates genomic and molecular pathology approaches to investigate how the tumor microenvironment drives development and treatment resistance in brain tumors

The Wang Laboratory at The Jackson Laboratory for Genomic Medicine is interested in understanding gene regulatory mechanisms that regulate leukemia survival, differentiation and therapy response.

The West Lab investigates how mitochondria shape immune and inflammatory responses in genetic disorders and aging-related diseases.