KEGG ORTHOLOGY: K00498

ORTHOLOGY: K00498

Entry

K00498                      KO

Symbol

CYP11A

Name

cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]

Pathway

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map04913

Ovarian steroidogenesis

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04934

Cushing syndrome

Module

M00107

Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone

Reaction

R01454

cholesterol:oxygen oxidoreductase (side-chain-cleaving)

R02723

R03933

20alpha,22beta-dihydroxycholesterol,ferredoxin:oxygen oxidoreductase (side-chain-cleaving)

R04676

17alpha,20alpha-dihydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)

R04854

20alpha-hydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)

R04855

22beta-hydroxycholesterol:oxygen oxidoreductase (side-chain-cleaving)

Disease

H02314

Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
   04925 Aldosterone synthesis and secretion
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
   04927 Cortisol synthesis and secretion
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6  cholesterol monooxygenase (side-chain-cleaving)
     K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP11 family
   K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)

Other DBs

GO:

0008386

Genes

HSA:	1583(CYP11A1)

PTR:	748998(CYP11A1)

PPS:	100979902(CYP11A1)

GGO:

PON:

PPYG:

NLE:

HMH:

SSYN:

MCC:

MCF:	102120640(CYP11A1)

MTHB:

126959982

MNI:

105490949

CSAB:

103245339(CYP11A1)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100389930(CYP11A1)

SBQ:

101039906

CIMI:

108317488(CYP11A1)

ANAN:

105733476(CYP11A1)

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	13070(Cyp11a1)

MCAL:

110301893

MPAH:

110328464

RNO:	29680(Cyp11a1)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:

CPOC:

CCAN:

DORD:

DSP:	122098454 122098455 122098456 122098457 122098458

PLOP:

125368228

NCAR:

124977503

MMMA:

107137576

OCU:	100345737(CYP11A1)

OPI:

101531464

TUP:

102487565

GVR:

103588064

CFA:	478365(CYP11A1)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:	101085980(CYP11A1)

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:

PPAD:

PUC:

AJU:

HHV:

BTA:	338048(CYP11A1)

BOM:

BIU:

BBUB:

BBIS:

CHX:	102173131(CYP11A1)

OAS:	100048994(CYP11A1)

BTAX:

128066929

CSUM:

138095450(CYP11A1)

ODA:

120875441

CCAD:

122455135

MREE:

136147391(CYP11A1)

MBEZ:

129550467

SSC:	403329(CYP11A1)

CFR:

CBAI:

CDK:

VPC:

BACU:

BMUS:

LVE:

OOR:

DLE:

PCAD:

PSIU:

NASI:

ECB:	100034229(CYP11A1)

EPZ:

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:

GAS:

SHR:

AFZ:

PCW:

TVP:	118828559 118829326 118829423

PBRV:

138148509(CYP11A1)

OAA:	100076626 114814661

GGA:	414838(CYP11A1)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

ACYG:

106044184(CYP11A1)

CATA:

118258137

AFUL:

116493636

TGU:	100151695(CYP11A1)

LSR:	110468679 110482567

PMOA:

OTC:

PRUF:

GFR:

FAB:

OMA:

PHI:

PMAJ:

ETL:

ZLE:

ACHL:

SVG:

SATI:

136366834(CYP11A1)

FPG:

FCH:

CCRI:

NNT:

SHAB:

ACUN:

TALA:

ACHC:

HLE:

AGEN:

GCL:

CSTI:

LDI:

DPUB:

PPUS:

AVIT:

BRHI:

EGZ:

NNI:

PCRI:

PCAO:

PADL:

AFOR:

CLV:

MUI:

PGUU:

EHS:

CMAC:

CUCA:

OHA:

ACAR:

CPEA:

CVF:

RTD:

AAM:

AROW:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102569028(CYP11A1)

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:	118079191 118084488

HCG:

128334996

GJA:

107111326

EMC:

129345167

XLA:	108712986(cyp11a1.S)

XTR:	100495360(cyp11a1)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:

DRE:	563363(cyp11a1.2) 80374(cyp11a1.1)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

CERY:

137014756(cyp11a1.2)

MASI:

TROS:

TDW:

MANU:

IPU:	100313513(cyp11a)

IFU:

PHYP:

SMEO:

TFD:

TVC:

TRN:

AMEX:

CMAO:

EEE:

CHAR:

TRU:

TFS:

TNG:	GSTEN00016006G001

LCO:

104924331

NCC:

104966693

TBEN:

117491684

CGOB:

115009784 115009785 115009786 115009787

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:

PFLV:

GAT:

PPUG:

AFB:

CLUM:

PSWI:

CANA:

137803927(cyp11a1.2)

CVE:	137881117(cyp11a1.2)

MSAM:

SCHU:

CUD:

ALAT:

ASTR:

137594363(cyp11a1.2)

MZE:

101471001

ONL:

100692956

OAU:

116326291

OLA:	100302421(cyp11a)

OML:

CSAI:

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

PPRL:

CVG:

CTUL:

GMU:

NFU:

KMR:

ALIM:

NWH:

AOCE:

EJA:	138206202(cyp11a1.2)

MCEP:

CSEM:

POV:

SSEN:

HHIP:

HSP:

PPLT:

SMAU:

LCF:

SDU:

SLAL:

XGL:

HCQ:

SSCV:

125970984(cyp11a1.2)

SBIA:

PEE:

PTAO:

BPEC:

MALB:

BSPL:

SJO:

SASA:

106561846(P450scc)

STRU:

OTW:

OMY:

OGO:

ONE:

OKI:

OKE:

SALP:

SNH:

CCLU:

ELS:

SFM:

PKI:

AANG:

LOC:

PSPA:

ARUT:

117428538 117429302 117963031

PSEX:

LCM:

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

BBEL:

109467542 109476488 109476522 109486367

AGB:

APLN:

CCRN:

PJA:

LJP:	135462469 135466761

» show all

Reference

PMID:3024157 (CYP11A1)

Authors

Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL

Title

Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.

Journal

Proc Natl Acad Sci U S A 83:8962-6 (1986)
DOI:10.1073/pnas.83.23.8962

Sequence

[hsa:1583]

Reference

PMID:15319355

Authors

Seals RC, Urban RJ, Sekar N, Veldhuis JD

Title

Up-regulation of basal transcriptional activity of the cytochrome P450 cholesterol side-chain cleavage (CYP11A) gene by isoform-specific calcium-calmodulin-dependent protein kinase in primary cultures of ovarian granulosa cells.

Journal

Endocrinology 145:5616-22 (2004)
DOI:10.1210/en.2003-1528

Reference

PMID:21159775

Authors

Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA

Title

Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.

Journal

J Biol Chem 286:5607-13 (2011)
DOI:10.1074/jbc.M110.188433

LinkDB

DBGET integrated database retrieval system