 | | ORTHOLOGY: K05087 | |
| Entry |
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| Symbol |
IGF1R, CD221
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| Name |
insulin-like growth factor 1 receptor [EC: 2.7.10.1]
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| Pathway |
| map01521 | EGFR tyrosine kinase inhibitor resistance |
| map04213 | Longevity regulating pathway - multiple species |
| map04550 | Signaling pathways regulating pluripotency of stem cells |
| map04914 | Progesterone-mediated oocyte maturation |
| map05202 | Transcriptional misregulation in cancer |
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| Disease |
| H00015 | Malignant pleural mesothelioma |
| H00048 | Hepatocellular carcinoma |
| H01274 | Growth delay due to insulin-like growth factor I resistance |
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| Brite |
KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04014 Ras signaling pathway
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04015 Rap1 signaling pathway
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04066 HIF-1 signaling pathway
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04068 FoxO signaling pathway
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04151 PI3K-Akt signaling pathway
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04152 AMPK signaling pathway
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04150 mTOR signaling pathway
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04140 Autophagy - animal
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09143 Cell growth and death
04114 Oocyte meiosis
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09144 Cellular community - eukaryotes
04510 Focal adhesion
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04520 Adherens junction
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04550 Signaling pathways regulating pluripotency of stem cells
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04914 Progesterone-mediated oocyte maturation
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09156 Nervous system
04730 Long-term depression
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09149 Aging
04211 Longevity regulating pathway
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
04213 Longevity regulating pathway - multiple species
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
05202 Transcriptional misregulation in cancer
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
05205 Proteoglycans in cancer
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09162 Cancer: specific types
05225 Hepatocellular carcinoma
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
05214 Glioma
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
05218 Melanoma
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
05215 Prostate cancer
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
05224 Breast cancer
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
01522 Endocrine resistance
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
09183 Protein families: signaling and cellular processes
04090 CD molecules
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
Enzymes [BR:ko01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
Protein kinases [BR:ko01001]
Receptor tyrosine kinases (RTK)
INSR family [OT]
K05087 IGF1R, CD221; insulin-like growth factor 1 receptor
CD molecules [BR:ko04090]
Proteins
K05087 CD221, IGF1R; insulin-like growth factor 1 receptor
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| Other DBs |
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| Genes |
» show all
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| Reference |
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| Authors |
Kasuya J, Paz IB, Maddux BA, Goldfine ID, Hefta SA, Fujita-Yamaguchi Y |
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| Title |
Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Ullrich A, Gray A, Tam AW, Yang-Feng T, Tsubokawa M, Collins C, Henzel W, Le Bon T, Kathuria S, Chen E, et al. |
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| Title |
Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. |
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| Sequence |
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| Reference |
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| Authors |
Siddle K, Urso B, Niesler CA, Cope DL, Molina L, Surinya KH, Soos MA |
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| Title |
Specificity in ligand binding and intracellular signalling by insulin and insulin-like growth factor receptors. |
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