KEGG   PATHWAY: gacu04150
Entry
gacu04150                   Pathway                                
Name
mTOR signaling pathway - Gymnodraco acuticeps
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
gacu04150  mTOR signaling pathway
gacu04150

Organism
Gymnodraco acuticeps [GN:gacu]
Gene
117539657  slc7a5; large neutral amino acids transporter small subunit 1 [KO:K13780]
117541931  large neutral amino acids transporter small subunit 1-like isoform X1 [KO:K13780]
117557539  4F2 cell-surface antigen heavy chain-like isoform X1 [KO:K06519]
117551738  slc3a2a; solute carrier family 3 member 2a [KO:K06519]
117552134  4F2 cell-surface antigen heavy chain [KO:K06519]
117534882  slc38a9; sodium-coupled neutral amino acid transporter 9 [KO:K14995]
117536884  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
117533067  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
117545291  atp6v1ba; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
117539740  atp6v1c2; V-type proton ATPase subunit C 1-B [KO:K02148]
117554338  V-type proton ATPase subunit C 1-A-like [KO:K02148]
117562882  atp6v1c1b; V-type proton ATPase subunit C 1-B [KO:K02148]
117562331  atp6v1d; V-type proton ATPase subunit D [KO:K02149]
117550814  atp6v1e1a; V-type proton ATPase subunit E 1a [KO:K02150]
117559161  atp6v1e1b; V-type proton ATPase subunit E 1 [KO:K02150]
117535241  atp6v1f; LOW QUALITY PROTEIN: V-type proton ATPase subunit F [KO:K02151]
117541015  atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
117534914  lamtor1; ragulator complex protein LAMTOR1 [KO:K20397]
117543188  lamtor2; ragulator complex protein LAMTOR2 [KO:K20398]
117563098  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
117535249  lamtor4; ragulator complex protein LAMTOR4 [KO:K20399]
117541962  lamtor5; ragulator complex protein LAMTOR5 [KO:K16344]
117533434  flcn; folliculin isoform X1 [KO:K09594]
117540089  fnip1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
117538499  rraga; ras-related GTP-binding protein A isoform X1 [KO:K16185]
117557433  rragca; ras-related GTP binding Ca [KO:K16186]
117536017  rragcb; ras-related GTP binding Cb [KO:K16186]
117536284  rragd; ras-related GTP-binding protein D [KO:K16186]
117562927  sesn2; sestrin-2 isoform X1 [KO:K20394]
117552073  castor1; cytosolic arginine sensor for mTORC1 subunit 1 [KO:K23080]
117551209  castor2; cytosolic arginine sensor for mTORC1 subunit 2 [KO:K23081]
117543159  mios; GATOR complex protein MIOS [KO:K20407]
117545881  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
117545067  wdr24; GATOR complex protein WDR24 [KO:K20408]
117545337  wdr59; GATOR complex protein WDR59 [KO:K20409]
117539932  sec13; protein SEC13 homolog isoform X1 [KO:K14004]
117545663  depdc5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
117548028  nprl2; GATOR complex protein NPRL2 isoform X1 [KO:K20405]
117548576  nprl3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
117542904  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
117537786  rnf152; E3 ubiquitin-protein ligase rnf152 [KO:K15705] [EC:2.3.2.27]
117562535  rptor; LOW QUALITY PROTEIN: regulatory-associated protein of mTOR [KO:K07204]
117548771  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
117532816  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117543762  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
117553721  deptor; LOW QUALITY PROTEIN: DEP domain-containing mTOR-interacting protein [KO:K20402]
117533574  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
117545066  telo2; telomere length regulation protein TEL2 homolog [KO:K11137]
117532854  tti1; TELO2-interacting protein 1 homolog [KO:K20403]
117561027  clip1a; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
117561473  clip1b; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
117537443  grb10b; growth factor receptor-bound protein 10 isoform X1 [KO:K20064]
117563045  growth factor receptor-bound protein 10-like isoform X1 [KO:K20064]
117556698  phosphatidate phosphatase LPIN1-like isoform X1 [KO:K15728] [EC:3.1.3.4]
117544680  phosphatidate phosphatase LPIN2-like isoform X1 [KO:K15728] [EC:3.1.3.4]
117533409  zgc:123305; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
117538576  si:ch73-21k16.1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
117541746  lpin2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
117543999  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
117554771  ulk1b; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
117562186  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
117560996  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
117532708  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
117538218  eif4e1c; eukaryotic translation initiation factor 4E family member 1c [KO:K03259]
117553596  eukaryotic translation initiation factor 4E-1A-like [KO:K03259]
117542408  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
117559882  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
117551643  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
117538454  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
117560252  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
117557596  eif4ba; eukaryotic translation initiation factor 4Ba isoform X1 [KO:K03258]
117538004  rps6; 40S ribosomal protein S6 [KO:K02991]
117548773  strada; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
117536489  stradb; STE20-related kinase adapter protein beta [KO:K17532]
117532607  stk11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
117550739  cab39l1; calcium binding protein 39, like 1 [KO:K08272]
117546911  cab39l; calcium-binding protein 39-like [KO:K08272]
117559793  cab39; LOW QUALITY PROTEIN: calcium-binding protein 39 [KO:K08272]
117555089  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
117561518  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
117539972  tsc1b; TSC complex subunit 1b [KO:K07206]
117561619  tsc2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
117560482  tbc1d7; TBC1 domain family member 7 [KO:K20396]
117551161  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
117541129  rheb; GTP-binding protein Rheb [KO:K07208]
117538225  DNA damage-inducible transcript 4 protein-like [KO:K08270]
117544704  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
117541847  wnt1; protein Wnt-1 [KO:K03209]
117537802  wnt2; protein Wnt-2 [KO:K00182]
117534176  protein Wnt-2b-A-like [KO:K00182]
117541885  protein Wnt-2b-A isoform X1 [KO:K00182]
117547058  wnt3; proto-oncogene Wnt-3 [KO:K00312]
117558461  wnt3a; protein Wnt-3a [KO:K00312]
117551813  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
117559501  wnt4; protein Wnt-4a [KO:K00408]
117557912  protein Wnt-5a-like [KO:K00444]
117542864  wnt5b; protein Wnt-5b [KO:K00444]
117553349  wnt6b; protein Wnt-6 [KO:K00445]
117547875  wnt7bb; protein Wnt-7b isoform X1 [KO:K00572]
117543124  protein Wnt-7a [KO:K00572]
117558278  wnt7ba; protein Wnt-7b [KO:K00572]
117538184  wnt8b; protein Wnt-8b isoform X1 [KO:K00714]
117545203  protein Wnt-8a-like [KO:K00714]
117545223  protein Wnt-8a-like isoform X1 [KO:K00714]
117548440  wnt9b; protein Wnt-9b [KO:K01064]
117558341  wnt9a; protein Wnt-9a [KO:K01064]
117553358  wnt10a; protein Wnt-10a isoform X1 [KO:K01357]
117541846  wnt10b; protein Wnt-10b [KO:K01357]
117553025  wnt11; protein Wnt-11 [KO:K01384]
117537178  wnt16; protein Wnt-16 isoform X1 [KO:K01558]
117546857  fzd1; frizzled-1 [KO:K02432]
117560088  frizzled-7-like [KO:K02432]
117548478  fzd2; frizzled-2 [KO:K02235]
117551420  frizzled-3-like [KO:K02329]
117554245  fzd3a; LOW QUALITY PROTEIN: frizzled-3a [KO:K02329]
117552261  fzd4; frizzled-4 [KO:K02354]
117550223  fzd8a; frizzled-8a [KO:K02375]
117544463  fzd5; frizzled-5 [KO:K02375]
117541282  LOW QUALITY PROTEIN: frizzled-8-like [KO:K02375]
117555452  frizzled-6-like [KO:K02376]
117543990  fzd10; LOW QUALITY PROTEIN: frizzled-10 [KO:K02842]
117557400  fzd9b; frizzled-9b [KO:K02842]
117532762  lrp5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
117532687  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
117552717  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
117543067  dvl1a; putative segment polarity protein dishevelled homolog DVL1P1 isoform X1 [KO:K02353]
117535811  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117535957  tumor necrosis factor-like [KO:K03156]
117548000  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117541843  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117560475  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117545246  insulin-like [KO:K04526]
117552873  insulin-like [KO:K04526]
117552476  igf1; insulin-like growth factor I [KO:K05459]
117547681  insulin-like growth factor I isoform X1 [KO:K05459]
117541280  insra; LOW QUALITY PROTEIN: insulin receptor a [KO:K04527] [EC:2.7.10.1]
117557655  igf1ra; LOW QUALITY PROTEIN: insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
117541527  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
117563188  growth factor receptor-bound protein 2 [KO:K04364]
117533890  sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
117545900  GTPase HRas [KO:K02833]
117544128  zgc:55558; GTPase HRas [KO:K07827]
117545716  kras; GTPase KRas isoform X1 [KO:K07827]
117547129  braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
117542983  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
117538865  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117532733  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
117546153  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
117544100  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
117546425  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117550720  rps6kal; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
117539783  rps6ka3b; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
117536468  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
117556398  rps6ka1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
117552674  si:ch73-335l21.1; insulin receptor substrate 1-B isoform X1 [KO:K16172]
117534032  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
117532612  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117545568  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
117535004  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
117542274  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117560597  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117561441  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117545508  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117534275  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117541887  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117542378  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
117548389  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117560847  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117545078  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
117544558  LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117551707  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117550034  akt1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117560397  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117560747  akt3a; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117536794  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
117547053  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117536922  mapkap1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
117543895  rapamycin-insensitive companion of mTOR-like isoform X1 [KO:K08267]
117545705  prr5a; proline-rich protein 5a isoform X1 [KO:K20411]
117536102  proline-rich protein 5-like isoform X1 [KO:K20411]
117551071  rho-related GTP-binding protein RhoA-B [KO:K04513]
117545976  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
117547686  rho-related GTP-binding protein RhoA-C [KO:K04513]
117541780  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
117542099  rho-related GTP-binding protein RhoA-D [KO:K04513]
117548684  si:ch73-374l24.1; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117561994  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
117551971  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
117556109  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117543213  prkcg; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117553922  sgk2b; LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk2b [KO:K13302] [EC:2.7.11.1]
117558085  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
117559327  si:ch211-195b13.1; STKc_SGK domain-containing protein isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
gacu00561  Glycerolipid metabolism
gacu04010  MAPK signaling pathway
gacu04140  Autophagy - animal
gacu04810  Regulation of actin cytoskeleton
gacu04910  Insulin signaling pathway
KO pathway
ko04150   
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