KEGG   PATHWAY: rphi04150
Entry
rphi04150                   Pathway                                
Name
mTOR signaling pathway - Ruditapes philippinarum (Manila clam)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
rphi04150  mTOR signaling pathway
rphi04150

Organism
Ruditapes philippinarum (Manila clam) [GN:rphi]
Gene
132725471  Y+L amino acid transporter 2-like [KO:K13780]
132759369  large neutral amino acids transporter small subunit 1-like [KO:K13780]
132759371  large neutral amino acids transporter small subunit 1-like [KO:K13780]
132758576  neutral amino acid transporter 9-like isoform X1 [KO:K14995]
132730485  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
132723784  V-type proton ATPase subunit B [KO:K02147]
132732079  V-type proton ATPase subunit C 1-A-like [KO:K02148]
132714256  V-type proton ATPase subunit D-like [KO:K02149]
132717536  V-type proton ATPase subunit D-like [KO:K02149]
132743890  V-type proton ATPase subunit E-like [KO:K02150]
132741411  V-type proton ATPase subunit F-like [KO:K02151]
132718774  V-type proton ATPase subunit G 1-like [KO:K02152]
132722887  V-type proton ATPase subunit H-like [KO:K02144]
132744574  ragulator complex protein LAMTOR1-like [KO:K20397]
132719806  ragulator complex protein LAMTOR2-like [KO:K20398]
132714603  ragulator complex protein LAMTOR3-B-like [KO:K04370]
132744307  ragulator complex protein LAMTOR4-like isoform X1 [KO:K20399]
132729679  folliculin-like [KO:K09594]
132738076  ras-related GTP-binding protein A [KO:K16185]
132754364  ras-related GTP-binding protein A [KO:K16185]
132733115  ras-related GTP-binding protein C-like isoform X1 [KO:K16186]
132721351  GATOR complex protein MIOS-like [KO:K20407]
132717698  nucleoporin SEH1-like isoform X1 [KO:K14299]
132722210  GATOR complex protein WDR24-like isoform X1 [KO:K20408]
132757722  GATOR complex protein WDR59-like isoform X1 [KO:K20409]
132716500  protein SEC13 homolog [KO:K14004]
132736468  GATOR complex protein Iml1-like [KO:K20404]
132755451  GATOR1 complex protein NPRL2-like [KO:K20405]
132735990  GATOR1 complex protein NPRL3-like [KO:K20406]
132731309  regulatory-associated protein of mTOR-like isoform X1 [KO:K07204]
132749557  serine/threonine-protein kinase mTOR-like [KO:K07203] [EC:2.7.11.1]
132747872  DEP domain-containing mTOR-interacting protein-like isoform X1 [KO:K20402]
132747422  target of rapamycin complex subunit lst8-like [KO:K08266]
132715905  telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
132749705  TELO2-interacting protein 1 homolog [KO:K20403]
132721374  CAP-Gly domain-containing linker protein 1-like [KO:K10421]
132713597  phosphatidate phosphatase LPIN3-like [KO:K15728] [EC:3.1.3.4]
132740845  serine/threonine-protein kinase ULK2-like isoform X1 [KO:K08269] [EC:2.7.11.1]
132729674  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
132730656  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
132731717  eukaryotic translation initiation factor 4E-like [KO:K03259]
132758464  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
132732338  eukaryotic translation initiation factor 4B-like isoform X1 [KO:K03258]
132754631  small ribosomal subunit protein eS6-like [KO:K02991]
132731953  STE20-related kinase adapter protein alpha-like [KO:K08271]
132746151  STE20-related kinase adapter protein alpha-like [KO:K08271]
132734009  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
132743812  protein Mo25-like [KO:K08272]
132745845  protein Mo25-like [KO:K08272]
132732530  5'-AMP-activated protein kinase catalytic subunit alpha-2-like isoform X1 [KO:K07198] [EC:2.7.11.31]
132726034  tuberin-like isoform X1 [KO:K07207]
132743303  TBC1 domain family member 7-like [KO:K20396]
132732758  GTP-binding protein Rheb-like [KO:K07208]
132743289  protein Wnt-1-like [KO:K03209]
132747988  protein Wnt-2b-A-like isoform X1 [KO:K00182]
132734930  protein Wnt-4-like [KO:K00408]
132716283  protein Wnt-4-like [KO:K00408]
132748104  protein Wnt-5a-like [KO:K00444]
132743290  protein Wnt-6-like isoform X1 [KO:K00445]
132755699  protein Wnt-7b-like isoform X1 [KO:K00572]
132749482  protein Wnt-10a-like [KO:K00714]
132743286  protein Wnt-9a-like [KO:K01064]
132743277  protein Wnt-10b-like [KO:K01357]
132717642  protein Wnt-11b-2-like [KO:K01384]
132738410  protein Wnt-16-like isoform X1 [KO:K01558]
132748164  frizzled-2-like [KO:K02432]
132751751  frizzled-4-like [KO:K02354]
132738611  frizzled-5-like [KO:K02375]
132759898  frizzled-9-like [KO:K02842]
132759294  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
132758811  glycogen synthase kinase-3 beta-like isoform X1 [KO:K03083] [EC:2.7.11.26]
132747585  uncharacterized protein LOC132747585 [KO:K03156]
132749616  uncharacterized protein LOC132749616 [KO:K03156]
132754719  uncharacterized protein LOC132754719 isoform X1 [KO:K03156]
132719512  molluscan insulin-related peptide 3-like [KO:K04526]
132720387  con-Ins Im2-like [KO:K04526]
132720388  insulin-like [KO:K04526]
132754243  con-Ins Im2-like [KO:K04526]
132757475  molluscan insulin-related peptide 1-like isoform X1 [KO:K04526]
132745906  con-Ins Im2-like [KO:K04526]
132745907  con-Ins Im2-like [KO:K04526]
132747199  insulin-like peptide receptor [KO:K04527] [EC:2.7.10.1]
132747200  insulin-like growth factor 1 receptor [KO:K04527] [EC:2.7.10.1]
132752167  growth factor receptor-bound protein 2-like isoform X1 [KO:K04364]
132728971  son of sevenless homolog 1-like isoform X1 [KO:K03099]
132739882  GTPase HRas [KO:K07827]
132742381  serine/threonine-protein kinase A-Raf-like isoform X1 [KO:K04365] [EC:2.7.11.1]
132749167  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
132724823  dual specificity mitogen-activated protein kinase kinase 1-like isoform X1 [KO:K04368] [EC:2.7.12.2]
132732172  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
132730668  ribosomal protein S6 kinase alpha-1-like isoform X1 [KO:K04373] [EC:2.7.11.1]
132749501  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
132722194  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
132730210  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
132758571  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
132735186  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
132753023  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
132730109  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
132760302  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
132738034  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
132729593  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
132743570  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
132723496  target of rapamycin complex 2 subunit MAPKAP1-like [KO:K20410]
132755258  target of rapamycin complex 2 subunit MAPKAP1-like [KO:K20410]
132748018  proline-rich protein 5-like [KO:K20411]
132748020  proline-rich protein 5-like [KO:K20411]
132748022  proline-rich protein 5-like isoform X1 [KO:K20411]
132736513  proline-rich protein 5-like [KO:K20411]
132726316  transforming protein RhoA-like [KO:K04513]
132757140  ras-like GTP-binding protein RHO [KO:K04513]
132722039  ras-like GTP-binding protein RHO [KO:K04513]
132719370  calcium-dependent protein kinase C-like isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
rphi00561  Glycerolipid metabolism
rphi04140  Autophagy - animal
KO pathway
ko04150   
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