Ca9 (carbonic anhydrase 9) - Rat Genome Database

Name: Ca9
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ca9 (carbonic anhydrase 9) Ictidomys tridecemlineatus

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Symbol:

Ca9

Name:

carbonic anhydrase 9

RGD ID:

12678977

Description:

ENCODES a protein that exhibits carbonate dehydratase activity (inferred); lyase activity (inferred); metal ion binding (inferred); INVOLVED IN morphogenesis of an epithelium (ortholog); response to hypoxia (ortholog); response to testosterone (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); Anaplasia (ortholog); anauxetic dysplasia (ortholog); FOUND IN basolateral plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CA9 (carbonic anhydrase 9)	NCBI	Ortholog
Mus musculus (house mouse):	Car9 (carbonic anhydrase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Car9 (carbonic anhydrase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ca9 (carbonic anhydrase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CA9 (carbonic anhydrase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CA9 (carbonic anhydrase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CA9 (carbonic anhydrase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CA9 (carbonic anhydrase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ca9 (carbonic anhydrase 9)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	167,124,669 - 167,131,057 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	3,672,541 - 3,678,433 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	3,672,393 - 3,678,630 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acromesomelic dysplasia, Maroteaux type (ISO)

Anaplasia (ISO)

anauxetic dysplasia (ISO)

autosomal recessive distal hereditary motor neuronopathy 2 (ISO)

breast carcinoma (ISO)

chronic myeloid leukemia (ISO)

distal arthrogryposis type 1A (ISO)

Ductal Carcinoma (ISO)

ductal carcinoma in situ (ISO)

endometrial hyperplasia (ISO)

Endometrioid Carcinomas (ISO)

Experimental Mammary Neoplasms (ISO)

Fibrosis (ISO)

frontotemporal dementia and/or amyotrophic lateral sclerosis 6 (ISO)

galactosemia (ISO)

hepatitis B (ISO)

hepatocellular carcinoma (ISO)

hyperphosphatasia with impaired intellectual development syndrome 2 (ISO)

Hypoxia (ISO)

lung non-small cell carcinoma (ISO)

Lymphatic Metastasis (ISO)

Lynch syndrome (ISO)

Metaplasia (ISO)

paraplegia (ISO)

primary ciliary dyskinesia (ISO)

pulmonary hypertension (ISO)

renal cell carcinoma (ISO)

Right Ventricular Hypertrophy (ISO)

transitional cell carcinoma (ISO)

urinary bladder cancer (ISO)

Uterine Cervical Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

morphogenesis of an epithelium (IEA,ISO)

response to hypoxia (ISO)

response to testosterone (ISO)

response to xenobiotic stimulus (ISO)

secretion (IEA,ISO)

Cellular Component

basolateral plasma membrane (ISO)

membrane (IEA)

plasma membrane (IEA)

Molecular Function

carbonate dehydratase activity (IEA)

lyase activity (IEA)

metal ion binding (IEA)

molecular function activator activity (IEA)

protein binding (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

hypoxia inducible factor pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ca9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	167,124,669 - 167,131,057 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936524	3,672,541 - 3,678,433 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936524	3,672,393 - 3,678,630 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CA9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	35,673,928 - 35,681,159 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	35,673,928 - 35,681,159 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	35,673,925 - 35,681,156 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	35,663,915 - 35,671,152 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	35,663,914 - 35,671,152	NCBI
Celera	9	35,607,463 - 35,614,702 (+)	NCBI		Celera
Cytogenetic Map	9	p13.3	NCBI
HuRef	9	35,629,523 - 35,636,764 (+)	NCBI		HuRef
CHM1_1	9	35,673,743 - 35,680,984 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	9	35,694,579 - 35,701,811 (+)	NCBI		T2T-CHM13v2.0

Car9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	43,507,026 - 43,513,729 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	43,506,966 - 43,513,729 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	43,507,026 - 43,513,729 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	43,506,966 - 43,513,729 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	43,519,898 - 43,526,597 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	43,528,107 - 43,534,829 (+)	NCBI		MGSCv36	mm8
Celera	4	43,540,895 - 43,547,584 (+)	NCBI		Celera
Cytogenetic Map	4	A5	NCBI
cM Map	4	23.05	NCBI

Car9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	62,559,024 - 62,565,626 (+)	NCBI		GRCr8
mRatBN7.2	5	57,763,234 - 57,769,838 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	57,763,206 - 57,769,838 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	59,743,112 - 59,749,748 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	61,561,925 - 61,568,564 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	61,533,190 - 61,539,753 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	59,008,277 - 59,015,535 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	59,008,933 - 59,015,528 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	63,533,527 - 63,540,129 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	59,986,413 - 59,993,015 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	59,986,589 - 59,992,484 (+)	NCBI
Celera	5	56,343,808 - 56,350,416 (+)	NCBI		Celera
Cytogenetic Map	5	q22	NCBI

Ca9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955472	619,245 - 625,051 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955472	619,084 - 625,570 (-)	NCBI	ChiLan1.0	ChiLan1.0

CA9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	88,906,190 - 88,913,457 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	88,912,119 - 88,919,393 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	35,525,877 - 35,533,159 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	36,328,205 - 36,335,474 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	36,328,303 - 36,335,340 (+)	Ensembl	panpan1.1		panPan2

CA9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	11	52,205,619 - 52,211,281 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	11	52,205,668 - 52,211,267 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	11	50,773,252 - 50,778,851 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	11	53,270,515 - 53,276,220 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	11	53,270,614 - 53,276,220 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	11	51,815,201 - 51,820,803 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	11	51,798,686 - 51,804,281 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	11	52,500,820 - 52,506,421 (+)	NCBI		UU_Cfam_GSD_1.0

CA9
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	236,394,306 - 236,400,822 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	236,393,727 - 236,400,994 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	264,118,816 - 264,126,024 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CA9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	44,921,530 - 44,929,504 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	44,921,665 - 44,928,831 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	42,026,370 - 42,034,593 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ca9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624868	5,109,846 - 5,116,949 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624868	5,110,602 - 5,131,167 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005326248	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000005042 ⟹ ENSSTOP00000004523

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936524	3,672,541 - 3,678,433 (+)	Ensembl

RefSeq Acc Id:

XM_005326248 ⟹ XP_005326305

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024404947	167,124,669 - 167,131,057 (+)	NCBI
SpeTri2.0	NW_004936524	3,672,393 - 3,678,630 (+)	NCBI

Sequence:

show sequence

GGGACTTTGGCTCCATCTCTACAAAAGGGCACTCTGTGAGTCAGCCTGCTCCCCTCAAGGCTCG
CTCCTCCCCCACCCAGCTCCTGTTTCCTATGCACGTACAGCCCGTACACACCACACCGTGTCCC
GGGACACCCCAGTCAGCCGCATGGCTTCCCTGTGCCCCAACCCCTGGCTCCCTCTGTTGATCCC
AGCCCCTACTGTGCAACTGCTGCTGTTGCTACTGCTCCTGGTGCCTGCCCATCCCCAGAAACTG
TCCTGGATGCAGGGGGATCACTCTATGGGAGGAGGTTCATCTGGGGAAGACAGTCCACTGGGCC
AGGAGGATTTGTACAGTGAAGAGGATCCACCTGGGGAGGAGGATTCACCTGAAATTACTTCTAA
ACCAGAAGAGGACAACTCCCTGAAGTTAGAGGATCTACCAACTGTTGAAGCTCCTGGGGACAGT
CAAGGTCACCCAAGTAAAGCTCCCGGGAACAAAAAAGGGGATGGCCACATTCATTGGCGCTACG
GAGGCAACCCGCCCTGGCCCCAGGTGTCCCCAGCCTGCGCAGGCCGCTTTCAGTCCCCCATAGA
TATCCGCCCGGAACTCACTGCGTTCAGCCGCGCGCTGCGACCCCCACAGCTTCAGGGTTTTGCG
CTACCGCCACGTCCGGAACTGCGCCTGCGCAACAATGGGCACACCGTGCAGCTGACTCTGCCTC
CCGGGCTGGAGATGGCCCTGGGTCCGGGGCGGGAGTACAGAGCCCTGCAGTTGCATCTGCACTG
GGGTACTTCGGATCGCCCGGGCTCAGAGCACTCTGTTGATGGCCACCATTTCCCTGCCGAGATC
CATGTAGTTCACCTCAGCACTGCATTTTCGGGAGTTGATGAGGCCTTGAGGCGCCCGGGAGGCC
TGGCGGTTTTGGCCGCCTTCCTACAGGAGGGCCCAGAAGAAAACAATGCCTATGAGCAGTTGCT
GTCACATTTGGAAGAAATTGCTGAGGAAGACTCAGAGATCTGGGTCCCAGGACTGGATGTATCA
GCCCTGCTGCCCTCTGACCTCAGCCGCTATTTCCGATATGAGGGATCTCTGACCACACCCCCCT
GTGCCCAGGGGGTCATCTGGACTGTGTTCAATCAGACAGTGAGGCTGAGTGCTAAGCAGCTCCA
CATCCTCTCCAGTTCCCTGTGGGAATCTCATGACTCTCGGCTACAGCTGAACTTCCGAGCCACA
CAGCCTTTGAATGGGCGAATGATTGAGGCCTCCTTCCCTGTTGAAGTGGACAGTCACCCTGAGC
CAGTCCACATGAATTCCTCCTGCCTTGCTGCCGGTGACATCCTGGCCCTGGTGTTTGGCTTCCT
GTTTGCTGTCACCAGTATCGCCTTCCTTGTGCAGATGGGGAGGCAGCACAGACACAGAAGTAGG
ACCAAAGAGGGTGTTAGCTACAGCCCACCAGAGATGGCGGAAACTGGAGCCTAGAAGCCCGGAA
CTTGGAAAATATGCAGATAAGCCAGCTAGAGGATTCTGGGGGGAGCTGGAAACTTTTTCCTATT
TTGCCCACTAGATGATTCCTTTTTAATTTCCAAAGAATGTTTCTTCTTCGTCTTTTCCCCCCTA
AAGCCACTGAAATGGGATCTTATAGTAGCAAAGCAAGATTGCACTCAACTTCCAGATTTTTTAA
AAAAATAAATATTCCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005326305	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004523.2
GenBank Protein	KAG3287489	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005326305 ⟸ XM_005326248

- UniProtKB:

I3M5C8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASLCPNPWLPLLIPAPTVQLLLLLLLLVPAHPQKLSWMQGDHSMGGGSSGEDSPLGQEDLYSE
EDPPGEEDSPEITSKPEEDNSLKLEDLPTVEAPGDSQGHPSKAPGNKKGDGHIHWRYGGNPPWP
QVSPACAGRFQSPIDIRPELTAFSRALRPPQLQGFALPPRPELRLRNNGHTVQLTLPPGLEMAL
GPGREYRALQLHLHWGTSDRPGSEHSVDGHHFPAEIHVVHLSTAFSGVDEALRRPGGLAVLAAF
LQEGPEENNAYEQLLSHLEEIAEEDSEIWVPGLDVSALLPSDLSRYFRYEGSLTTPPCAQGVIW
TVFNQTVRLSAKQLHILSSSLWESHDSRLQLNFRATQPLNGRMIEASFPVEVDSHPEPVHMNSS
CLAAGDILALVFGFLFAVTSIAFLVQMGRQHRHRSRTKEGVSYSPPEMAETGA

hide sequence

Ensembl Acc Id:

ENSSTOP00000004523 ⟸ ENSSTOT00000005042

Protein Domains

Alpha-carbonic anhydrase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000005040	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000005042.3	UniProtKB/TrEMBL
Gene3D-CATH	3.10.200.10	UniProtKB/TrEMBL
InterPro	CA_dom	UniProtKB/TrEMBL
	CA_dom_sf	UniProtKB/TrEMBL
	Carbonic_anhydrase_a-class	UniProtKB/TrEMBL
	Carbonic_anhydrase_a-class_CS	UniProtKB/TrEMBL
NCBI Gene	Ca9	ENTREZGENE
PANTHER	PTHR18952	UniProtKB/TrEMBL
	PTHR18952:SF18	UniProtKB/TrEMBL
Pfam	Carb_anhydrase	UniProtKB/TrEMBL
PROSITE	ALPHA_CA_1	UniProtKB/TrEMBL
	ALPHA_CA_2	UniProtKB/TrEMBL
SMART	Carb_anhydrase	UniProtKB/TrEMBL
Superfamily-SCOP	SSF51069	UniProtKB/TrEMBL
UniProt	I3M5C8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)