MC180295 is a highly potent and selective CDK9 inhibitor with preclinical in vitro and in vivo efficacy in cancer
Zhang H, Huang C, Gordon J, Yu S, Morton G, Childers W, Abou-Gharbia M, Zhang Y, Jelinek J, Issa JJ.
Clin Epigenetics. 2024 Jan 3;16(1):3. doi: 10.1186/s13148-023-01617-3. PMID: 38172923; PMCID:
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Use of genome-wide DNA methylation analysis to identify prognostic CpG site markers associated with longer survival time in dogs with multicentric high-grade B-cell lymphoma
Teoh YB, Ishizaki T, Kagawa Y, Yokoyama S, Jelinek J, Matsumoto Y, Tomiyasu H, Tsujimoto H, Takiguchi M, Yamazaki J.
J Vet Intern Med. 2023 Dec 19. doi: 10.1111/jvim.16931. Epub ahead of print. PMID: 38115210.
Postmortem toxicology findings from the Camden Opioid Research Initiative
Kusic DM, Heil J, Zajic S, Brangan A, Dairo O, Heil S, Feigin G, Kacinko S, Buono RJ, Ferraro TN, Rafeq R, Haroz R, Baston K, Bodofsky E, Sabia M, Salzman M, Resch A, Madzo J, Scheinfeldt LB, Issa JJ, Jelinek J
PLoS One. 2023 Nov 1;18(11):e0292674. doi: 10.1371/journal.pone.0292674. PMID: 37910493; PMCID:
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Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD
Wang Y, He S, Calendo G, Bui T, Tian Y, Lee CY, Zhou Y, Zhao X, Abraham C, Mo W, Chen M, Sanders-Braggs R, Madzo J, Issa JP, Hexner EO, Wiest DL, Reshef R, Xue HH, Zhang Y
Blood. 2024 Jan 11;143(2):166-177. doi: 10.1182/blood.2023021126. PMID: 37871574
Decitabine disrupts EBV genomic epiallele DNA methylation patterns around CTCF binding sites to increase chromatin accessibility and lytic transcription in gastric cancer
Preston-Alp S, Caruso LB, Su C, Keith K, Soldan SS, Maestri D, Madzo J, Kossenkov A, Napoletani G, Gewurz B, Lieberman PM, Tempera I
mBio. 2023 Oct 31;14(5):e0039623. doi: 10.1128/mbio.00396-23. Epub 2023 Aug 22. PMID: 37606370; PMCID: PMC10653948
Diverse genome-wide DNA methylation alterations in canine hepatocellular tumours
Asari Y, Yamazaki J, Thandar O, Suzuki T, Aoshima K, Takeuchi K, Kinoshita R, Kim S, Hosoya K, Ishizaki T, Kagawa Y, Jelinek J, Yokoyama S, Sasaki N, Ohta H, Nakamura K, Takiguchi M.
Vet Med Sci. 2023 Sep;9(5):2006-2014. doi:10.1002/vms3.1204. Epub 2023 Jul 22. PMID: 37483163; PMCID: PMC10508506
Guadecitabine vs treatment choice in newly diagnosed acute myeloid leukemia: a global phase 3 randomized study
Fenaux P, Gobbi M, Kropf PL, Issa JJ, Roboz GJ, Mayer J, Krauter J, Robak T, Kantarjian H, Novak J, Jedrzejczak WW, Thomas X, Ojeda-Uribe M, Miyazaki Y, Min YH, Yeh SP, Brandwein J, Gercheva-Kyuchukova L, Demeter J, Griffiths E, Yee K, Döhner K, Hao Y, Keer H, Azab M, Döhner H
Blood Adv. 2023 Sep 12;7(17):5027-5037. doi: 10.1182/bloodadvances.2023010179. PMID: 37276510; PMCID: PMC10471926.
Author Correction: DNA methylation entropy as a measure of stem cell replication and aging
Vaidya H, Jeong HS, Keith K, Maegawa S, Calendo G, Madzo J, Jelinek J, Issa JJ.
Genome Biol. 2023 Apr 30;24(1):104. doi: 10.1186/s13059-023-02943-8. Erratum for: Genome Biol. 2023 Feb 16;24(1):27. PMID: 37122020.
Promoter-Independent Synthesis of Chemically Modified RNA by Polymerase θ Variants
Tredinnick TN, Kent T, Minakhin L, Li Z, Madzo J, Chen XS, Pomerantz RT
RNA. 2023 Apr 27:rna.079396.122. doi: 10.1261/rna.079396.122. Epub ahead of print. PMID: 37105714.
ABL1 kinase as a tumor suppressor in AML1-ETO and NUP98-PMX1 leukemias
Golovine K, Abalakov G, Lian Z, Chatla S, Karami A, Chitrala KN, Madzo J, Nieborowska-Skorska M, Huang J, Skorski T.
Blood Cancer J. 2023 Mar 23;13(1):42. doi:10.1038/s41408-023-00810-0. PMID: 36959186; PMCID: PMC10036529.
A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy
Jang HJ, Hostetter G, MacFarlane AW, Madaj Z, Ross EA, Hinoue T, Kulchycki JR, Burgos RS, Tafseer M, Alpaugh RK, Schwebel CL, Kokate R, Geynisman DM, Zibelman MR, Ghatalia P, Nichols PW, Chung W, Madzo J, Hahn NM, Quinn DI, Issa JJ, Topper MJ, Baylin SB, Shen H, Campbell KS, Jones PA, Plimack ER.
Clin Cancer Res. 2023 Mar 16:CCR-22-3642. doi: 10.1158/1078-0432.CCR-22-3642. Epub ahead of print. PMID: 36928921.
DNA methylation entropy as a measure of stem cell replication and aging
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Genome Biol. 2023 Feb 16;24(1):27. doi: 10.1186/s13059-023-02866-4. Erratum in: Genome Biol. 2023 Apr 30;24(1):104. PMID: 36797759; PMCID: PMC9933260.
TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype
Tricarico R, Madzo J, Scher G, Cohen M, Jelinek J, Maegawa S, Nagarathinam R, Scher C, Chang WC, Nicolas E, Slifker M, Zhou Y, Devarajan K, Cai KQ, Kwok T, Nakajima P, Xu J, Mancuso P, Doneddu V, Bagella L, Williams R, Balachandran S, Maskalenko N, Campbell K, Ma X, Cañadas I, Viana-Errasti J, Moreno V, Valle L, Grivennikov S, Peshkova I, Kurilenko N, Mazitova A, Koltsova E, Lee H, Walsh M, Duttweiler R, Whetstine JR, Yen TJ, Issa JP, Bellacosa A.
Gastroenterology. 2023 May;164(6):921-936.e1. doi: 10.1053/j.gastro.2023.01.039. Epub 2023 Feb 8. PMID:
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Hypomethylation in MTNR1B: a novel epigenetic marker for atherosclerosis profiling using stenosis radiophenotype and blood inflammatory cells
Kim JY, Jelinek J, Lee YH, Kim DH, Kang K, Ryu SH, Moon HR, Cho K, Rha SH, Cha JK, Issa JJ, Kim J.
Clin Epigenetics. 2023 Jan 19;15(1):11. doi: 10.1186/s13148-023-01423-x. PMID: 36658621; PMCID: PMC9854223.
Novel treatment strategy of targeting epigenetic dysregulation in pancreatic neuroendocrine tumors
Zhu C, Sandilos G, Williamson J, Emery R, Platoff R, Joneja U, Acharya NK, Lin A, Badach J, Zilberman B, Madzo J, Jelinek J, Zhang P, Hong YK.
Surgery. 2023 Apr;173(4):1045-1051. doi: 10.1016/j.surg.2022.12.008. Epub 2023 Jan 13. PMID: 36642656.
DNA polymerase theta protects leukemia cells from metabolic-induced DNA damage
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Matlawska-Wasowska K, Chandramouly G, Nejati R, Wasik MA, Sykes S, Piwocka K, Hadzijusufovic E, Valent P, Pomerantz RT, Morton G, Childers W, Zhao H, Paietta E, Levine RL, Tallman MS, Fernandez H, Litzow MR, Gupta G, Masson JY, Skorski T
Blood. 2022 Dec 29:blood.2022018428. doi: 10.1182/blood.2022018428. Epub ahead of print. PMID: 36580665.
Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa
Sun A, Park P, Cole L, Vaidya H, Maegawa S, Keith K, Calendo G, Madzo J, Jelinek J, Jobin C, Issa JJ.
Epigenetics. 2022 Dec 26:1-14. doi: 10.1080/15592294.2022.2160568. Epub ahead of print. PMID: 36572998.
Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells
O'Connell CL, Baer MR, Ørskov AD, Saini SK, Duong VH, Kropf P, Hansen JW, Tsao-Wei D, Jang HS, Emadi A, Holmberg-Thyden S, Cowland J, Brinker BT, Horwood K, Burgos R, Hostetter G, Youngblood BA, Hadrup SR, Issa JP, Jones P, Baylin SB, Pandey S, Djibo R, Darracq A, Calendo G, Zhang H, Henry RA, Andrews AJ, Baylin SB, Madzo J, Najmanovich R, Issa JJ, Raynal NJ.
Cancers (Basel). 2022 Jul 8;14(14):3340. doi: 10.3390/cancers14143340. PMID: 35884401; PMCID: PMC9324262.
Prospective comparison of outcomes with azacitidine and decitabine in patients with AML ineligible for
intensive chemotherapy
Zeidan AM, Fenaux P, Gobbi M, Mayer J, Roboz GJ, Krauter J, Robak T, Kantarjian HM, Novák J, Jedrzejczak WW, Thomas X, Ojeda-Uribe M, Miyazaki Y, Min YH, Yeh SP, Brandwein JM, Gercheva L, Demeter J, Griffiths EA, Yee KWL, Issa JJ, Bewersdorf JP, Keer H, Hao Y, Azab M, Döhner H.
Blood. 2022 Jul 21;140(3):285-289. doi: 10.1182/blood.2022015832. PMID: 35507690; PMCID: PMC9305088.
Single cell transcriptomic analysis reveals cellular diversity of murine esophageal
epithelium
Kabir MF, Karami AL, Cruz-Acuña R, Klochkova A, Saxena R, Mu A, Murray MG, Cruz J, Fuller AD, Clevenger MH, Chitrala KN, Tan Y, Keith K, Madzo J, Huang H, Jelinek J, Karakasheva T, Hamilton KE, Muir AB, Tétreault MP, Whelan KA.
Nat Commun. 2022 Apr 20;13(1):2167. doi: 10.1038/s41467-022-29747-x. PMID: 35443762; PMCID: PMC9021266.
The Two-Hit Hypothesis Meets Epigenetics
Issa JP
Cancer Res. 2022 Apr 1;82(7):1167-1169. doi: 10.1158/0008-5472.CAN-22-0405. PMID: 35373289.
Genome-wide DNA methylation profile in feline haematological tumours: A preliminary study
Yamazaki J, Jelinek J, Yokoyama S, Takiguchi M.
Res Vet Sci. 2021 Nov;140:221-228. doi: 10.1016/j.rvsc.2021.09.002. Epub 2021 Sep 8. PMID: 34534903.
Obese status is associated with accelerated DNA methylation change in peripheral blood of senior dogs
Yamazaki J, Meagawa S, Jelinek J, Yokoyama S, Nagata N, Yuki M, Takiguchi M.
Res Vet Sci. 2021 Oct;139:193-199. doi: 10.1016/j.rvsc.2021.07.024. Epub 2021 Jul 24. PMID: 34358922.
The Roles of DNA Demethylases in Triple-Negative Breast Cancer
Panjarian S, Issa JJ.
Pharmaceuticals (Basel). 2021 Jun 29;14(7):628. doi: 10.3390/ph14070628. PMID: 34209564; PMCID: PMC8308559.
Accelerated aging in normal breast tissue of women with breast cancer
Panjarian S, Madzo J, Keith K, Slater CM, Sapienza C, Jelinek J, Issa JJ.
Breast Cancer Res. 2021 May 22;23(1):58. doi: 10.1186/s13058-021-01434-7. PMID: 34022936; PMCID: PMC8140515.
DNA methylation landscape of 16 canine somatic tissues by methylation-sensitive restriction enzyme-based next
generation sequencing
Yamazaki J, Matsumoto Y, Jelinek J, Ishizaki T, Maeda S, Watanabe K, Ishihara G, Yamagishi J, Takiguchi M.
Sci Rep. 2021 May 11;11(1):10005. doi: 10.1038/s41598-021-89279-0. PMID: 33976289; PMCID: PMC8113467.
Genome-wide DNA methylation analysis of dogs with high lead exposure living near a lead mining area in Kabwe, Zambia
Yamazaki J, Toyomaki H, Nakayama SMM, Yabe J, Muzandu K, Jelinek J, Yokoyama S, Ikenaka Y, Takiguchi M, Ishizuka M.
Environ Pollut. 2021 Oct 1;286:117229. doi: 10.1016/j.envpol.2021.117229. Epub 2021 May 3. PMID: 33975213.
Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas
Hu X, Estecio MR, Chen R, Reuben A, Wang L, Fujimoto J, Carrot-Zhang J, McGranahan N, Ying L, Fukuoka J, Chow CW, Pham HHN, Godoy MCB, Carter BW, Behrens C, Zhang J, Antonoff MB, Sepesi B, Lu Y, Pass HI, Kadara H, Scheet P, Vaporciyan AA, Heymach JV, Wistuba II, Lee JJ, Futreal PA, Su D, Issa JJ, Zhang J.
Nat Commun. 2021 Jan 29;12(1):687. doi: 10.1038/s41467-021-20907-z. PMID: 33514726; PMCID: PMC7846738.
Cellular Heterogeneity-Adjusted cLonal Methylation (CHALM) improves prediction of gene expression
Xu J, Shi J, Cui X, Cui Y, Li JJ, Goel A, Chen X, Issa JP, Su J, Li W.
Nat Commun. 2021 Jan 15;12(1):400. doi: 10.1038/s41467-020-20492-7. PMID: 33452255; PMCID: PMC7811027.
Promoter methylation changes in ALOX12 and AIRE1: novel epigenetic markers for atherosclerosis
Kim JY, Choi BG, Jelinek J, Kim DH, Lee SH, Cho K, Rha SH, Lee YH, Jin HS, Choi DK, Kim GE, Kwon SU, Hwang J, Cha JK, Lee S, Issa JJ, Kim J.
Clin Epigenetics. 2020 May 12;12(1):66. doi: 10.1186/s13148-020-00846-0. PMID: 32398127; PMCID: PMC7218560.
Genome-wide DNA methylation analysis in canine gastrointestinal lymphoma
Ohta H, Yamazaki J, Jelinek J, Ishizaki T, Kagawa Y, Yokoyama N, Nagata N, Sasaki N, Takiguchi M.
J Vet Med Sci. 2020 May 20;82(5):632-638. doi: 10.1292/jvms.19-0547. Epub 2020 Mar 25. PMID: 32213750; PMCID: PMC7273592.
Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia
Chung W, Kelly AD, Kropf P, Fung H, Jelinek J, Su XY, Roboz GJ, Kantarjian, HM, Azab M, Issa JJ.
Clin Epigenetics. 2019 Jul 22;11(1):106. doi: 10.1186/s13148-019-0704-3. PMID: 31331399; PMCID: PMC6647096.
