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Publications

  1. Jin J*, Huo L, Fan Y, Wang R, Scott AW, Pizzi MP, Yao X, Shao S, Ma L, Da Silva MS, Yamashita K, Yoshimura K, Zhang B, Wu J, Wang L, Song S*, Ajani JA*. A new intronic quantitative PCR method led to the discovery of transformation from human ascites to murine malignancy in a mouse model. Front Oncol. 2023 Feb 6;13:1062424. doi: 10.3389/fonc.2023.1062424.PMID: 36865791; *co-corresponding author.
  2. Hirata Y, Noorani A, Song S, Wang L, and Ajani JA. Early-Stage Gastric Adenocarcinoma:   Clinical and Molecular Landscapes. Nat Rev Clin Oncol. 2023 Jun 1.  doi: 10.1038/s41571-023-00767-w. Online ahead of print. PMID: 37264184
  3. Fan Y, Song S*, Li Y, Dhar S, Jin J, Yao X, Wang R, Scott AW, Pool Pizzi M, Wu J, Yoshimura K, Ma L, Hanash S, Calin GA, Wang L, Curran M, Ajani JA*. Galectin-3 synergizes with CD47 to Suppress Phagocytosis and T cell immunity in Peritoneal Metastases from Gastric Adenocarcinoma. Cancer Res. 2023 Sep 22. doi: 10.1158/0008-5472.CAN-23-0783. Online ahead of print.PMID: 37738407. *co-corresponding author.
  4. Chu Y, Li Y , Dai E, Han G, Thakkar K, Dang M, Qin J, Le X, Deng Q, Sinjab A, Gupta P, Wang R, Hao H, Peng F, Yan X, Song S, Lu Y, Zhang S, Marsden A, Heymach J, Reuben A, Elamin Y, Pizzi M, Futreal A, Maitra A, Jazaeri A, Cheng X, Ajani JA, Swanton C, Abbas H, Gillison M, Bhat K, Green M, Kadara H, Litchfield K, Yee C, Wang L Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance; Nat Med. 2023 May 29. doi: 10.1038/s41591-023-02371. Online ahead of print. PMID: 37248301.
  5. Fan Y, Li Y, Yao X, Jin J, Scott AW, Liu B, Wang S, Huo L, Wang Y, Wang R, Pizzi M, Ma L, Shao S, Sewastjanow Da Silva M, Waters RE, Chatterjee D, Liu B, Shanbhag N, Peng G, Calin GA, Mazur PM, Hanash S, Ishizawa J, Hirata Y, Nagano O, Wang Z, Wang L, Xian W, McKeon F, Ajani JA,*, Song S,* Epithelial SOX9 Drives Progression and Metastases of Gastric Adenocarcinoma by Promoting Immunosuppressive Tumor Microenvironment. Gut. 2023 Apr;72(4):624-637. doi: 10.1136/gutjnl-2021-326581. Epub 2022 Aug 24. PMID: 36002248 *corresponding author.
  6. Zou G, Huang Y, Zhang S, Ko KP, Kim B, Zhang J, Venkatesan V, Pizzi MP, Fan Y, Jun S, Niu N, Wang H, Song S, Ajani JA, Park JI. CDH1 loss promotes diffuse-type gastric cancer tumorigenesis via epigenetic reprogramming and immune evasion; bioRxiv. 2023 Apr 4:2023.03.23.533976. doi: 10.1101/2023.03.23.533976
  7. Jin J, Yoshimura K, Sewastjanow-Silva M, Song S, Ajani JA. Challenges and Prospects of Patient-Derived Xenografts for Cancer Research. Cancers (Basel). 2023 Aug 31;15(17):4352. doi: 10.3390/cancers15174352.PMID: 37686627
  8. Zhao S, Wang R, Song S, Hao D, Han G, Song X, Zhang J, Pizzi MP, Shanbhag N, Futreal A, Badgwell B, Harada K, Calin G, Vykoukal J, Yu CY, Katayama H, Hanash SM, Wang L, Ajani JA. Proteogenomic landscape of gastric adenocarcinoma peritoneal metastases. iScience. 2023 May 19;26(6):106913. doi: 10.1016/j.isci.2023.106913. eCollection 2023 Jun 16. PMID: 37305699
  9. Jeong YS, Eun YG, Lee SH, Kang SH, Yim SY, Kim EH, Noh JK, Sohn BH, Woo SR, Kong M, Nam DH, Jang HJ, Lee HS, Song S, Oh SC, Lee J, Ajani JA, Lee JS. Clinically conserved genomic subtypes of gastric adenocarcinoma. Mol Cancer. 2023 Sep 6;22(1):147. doi: 10.1186/s12943-023-01796-w.PMID: 37674200
  10. Li Y, Fan Y, Xu J, Huo L, Scott AW, Jin J, Yang B, Shao S, Ma L, Wang Y, Yao X, Pool Pizzi M, Sewastjanow Da Silva M, Zhang G, Zhuo L, Cho EJ, Dalby KN, Shanbhag ND, Wang Z, Li W, Song S*, Ajani JA*. GRK3 is a poor prognosticator and serves as a therapeutic target in advanced gastric adenocarcinoma; J Exp Clin Cancer Res. 2022 Aug 23;41(1):257. PMID: 35996148 *co-corresponding author.
  11. Dong X, Song S*, Li Y, Fan Y, Wang L, Wang R, Huo L, Scott A, Xu Y, Pizzi MP, Ma L, Wang Y, Jin J, Zhao W, Yao X, Johnson RL, Wang L, Wang Z, Peng G, Ajani JA*. Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma-rationale for targeting ARID1A deficiency; Gut. 2022 Mar;71(3):467-478. PMID: 33785559. *corresponding author.
  12. Song S*, Xu Y, Huo L, Zhao S, Wang R, Li Y, Scott A, Pizzi MP, Wang Y, Fan Y, Harada K, Jin J, Ma L, Yao X, Shanbhag ND, Gan Q, Roy-Chowdhuri S, Badgwell BD, Wang Z, Wang L, Ajani JA*. Patient-derived cell lines and orthotopic mouse model of peritoneal carcinomatosis recapitulate molecular and phenotypic features of human gastric adenocarcinoma. J Exp Clin Cancer Res., 2021 Jun 23;40(1):207. doi: 10.1186/s13046-021-02003-8. PMID: 34162421. *corresponding author.
  13. Wang R, Dang M, Harada K, Han G, Wang F, Pizzi M, Zhao M, Tatlonghari G, Zhang S, Hao D, Lu Y, Zhao S, Badgwell BD, Murphy MB, Shanbhag N, Estrella JS, Roy-Chowdhuri S, Ahmed Abdelhakeem A, Wang Y, Peng G, Hanash S, Calin GA, Song X, Chu Y, Zhang Z, Li M, Chen K, Lazar AJ, Futreal A, Song S, Ajani JA, Wang L . Single cell lineage diversity of metastatic gastric adenocarcinnoma contributes to the inherent intratumoral heterogeneity and a fundamental prognostic signature. Nat Med. 2021 Jan;27(1):141-151. PMID: 33398161
  14. Xu Y, Li Y, Jin J, Han G, Sun C, Pizzi MP, Huo L, Scott A, Wang Y, Ma L, Lee JH, Bhutani MS, Weston B, Vellano C, Yang L, Lin C, Kim Y, MacLeod AR, Wang L, Wang Z, Song S, Ajani JA Correction to: LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma; Mol Cancer. 2021 Mar 25;20(1):56. doi: 10.1186/s12943-021-01351-5. Mol Cancer. 2021. PMID: 33766033
  15. Badgwell B, Ikoma N, Murphy MB, Wang X, Estrella J, Roy-Chowdhuri S, Das P, Minsky BD, Lano E, Song S, Mansfield P, Ajani J. A Phase II Trial of Cytoreduction, Gastrectomy, and Hyperthermic Intraperitoneal Perfusion with Chemotherapy for Patients with Gastric Cancer and Carcinomatosis or Positive Cytology. Ann Surg Oncol. 2021 Jan;28(1):258-264. PMID:32556731
  16. Song S*, Chen Q, Li Y, Lei G, Scott A, Huo L, Li CY, Estrella JS, Correa A, Pizzi MP, Ma L, Jin J, Liu B, Wang Y, Xiao L, Hofstetter WL, Lee JH, Weston B, Bhutani M, Shanbhag N, Johnson RL, Gan B, Wei S, Ajani JA*. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma; Gut. 2021 Dec;70(12):2238-2248. PMID: 33487592 . *corresponding author.
  17. Ajani JA, Xu Y, Huo L, Wang R, Li Y, Wang Y, Pizzi MP, Scott A, Harada K, Ma L, Yao X, Jin J, Zhao W, Dong X, Badgwell BD, Shanbhag N, Tatlonghari G, Estrella JS, Roy-Chowdhuri S, Kobayashi M, Vykoukal JV, Hanash SM, Calin GA, Peng G, Lee JS, Johnson RL, Wang Z, Wang L, Song S*. YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition. Gut. 2021 Jan;70(1):55-66. PubMed PMID: 32345613. *corresponding author.
  18. Chen HY, Feng LL, Li M, Ju HQ, Ding Y, Lan M, Song S, Han WD, Yu L, Wei MB, Pang XL, He F, Liu S, Zheng J, Ma Y, Lin CY, Lan P, Huang MJ, Zou YF, Yang ZL, Wang T, Lang JY, Orangio GR, Poylin V, Ajani JA, Wang WH, Wan XB. College of American Pathologists Tumor Regression Grading System for Long-Term Outcome in Patients with Locally Advanced Rectal Cancer Oncologist. 2021 May;26(5):e780-e793. PMID: 33543577
  19. Hao D, He S, Harada K, Pizzi MP, Lu Y, Guan P, Chen L, Wang R, Zhang S, Sewastjanow-Silva M, Abdelhakeem A, Shanbhag N, Bhutani M, Han G, Lee JH, Zhao S, Weston B, Blum Murphy M, Waters R, Estrella JS, Roy-Chowdhuri S, Gan Q, Lee JS, Peng G, Hanash SM, Calin GA, Song X, Zhang J, Song S, Wang L, Ajani JA.  Integrated genomic profiling and modelling for risk stratification in patients with advanced oesophagogastric adenocarcinoma. Gut. 2021 Nov;70(11): 2055-2065. PMID: 33334899
  20. Song S*, Wang Z, Li Y, Ma L, Jin J, Scott AW, Xu Y, Estrella JS, Song Y, Liu B, Johnson RL, Ajani JA. PPARδ Interacts with the Hippo Coactivator YAP1 to Promote SOX9 Expression and Gastric Cancer Progression; Mol Cancer Res. 2020, 18(3):390-402 *Corresponding author
  21. Jin J, Xu Y, Huo L, Ma L, Scott AW, Pizzi MP, Li Y, Wang Y, Yao X, Song S*, Ajani JA*. An improved strategy for CRISPR/Cas9 gene knockout and subsequent wildtype and mutant gene rescue. PLoS One. 2020;15(2):e0228910. doi: 10.1371/journal.pone.0228910. eCollection 2020. PMID: 32053639.*Corresponding author
  22. Wang R, Song S*, Harada K, Ghazanfari Amlashi F, Badgwell BD, Pizzi M, Xu Y1, Zhao W, Dong X, JinJ, Wang Y, Scott A, Ma L, Huo L, Vicente D, Blum Murphy M, Shanbhag N, Tatlonghari G, Thomas I, RogersJ, Kobayash M5, Jody V Vykoukal5, Jeannelyn S. Estrella6, Sinchita Roy-Chowdhuri6, Guangchun Han1, Zhan S, Mao X, Song X, Zhang J, Gu J, Johnson RL, CalinGA, Peng G, Lee JS, Hanash S, Futreal A, Wang ZN, Wang LH*& Ajani JA*. Multiplex Profiling of Peritoneal Metastases from Gastric Adenocarcinoma Identified Novel Targets and Molecular Subtypes that Predict Treatment Response. GUT, 2020 Jan;69 (1):18-31. *co-corresponding author.
  23. Song S*, Li Y, Xu Y, Ma L, Pool Pizzi M, Jin J, Scott AW, Huo L, Wang Y, Lee JH, Bhutani MS, Weston B, Shanbhag ND, Johnson RL, Ajani JA*. Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma. Mol Oncol. 2020;14(6):1410-1426. PMID: 32175692. *co-corresponding author.
  24. Li Y, Song S*, Pizzi MP, Han G, Scott AW, Jin J, Xu Y, Wang Y, Huo L, Ma L, Vellano C, Luo X, MacLeod R, Wang L, Wang Z, Ajani JA*. LncRNA PVT1 Is a Poor Prognosticator and Can Be Targeted by PVT1 Antisense Oligos in Gastric Adenocarcinoma. Cancers (Basel). 2020 Oct 15;12(10):2995. *co-corresponding author.
  25. Yao X, Ajani JA and Song S*. Molecular biology and immunology of gastric cancer peritoneal metastasis. Review article. Transl Gastroenterol Hepatol. 2020 Oct 5;5:57. doi: 10.21037/tgh.2020.02.08. eCollection 2020. PMID: 33073052 *co-corresponding author. 
  26. Murphy B, Ikoma N, Wang X, Estrella J, Roy-Chowdhuri S, Das P, Minsky BD, Song S, Mansfield P, Ajani JA, Badgwell  B. Phase I Trial of Hyperthermic Intraperitoneal Chemoperfusion (HIPEC) with Cisplatin, Mitomycin, and Paclitaxel in Patients with Gastric Adenocarcinoma and Associated Carcinomatosis or Positive Cytology. Ann Surg Oncol 2020; 27(8):2806-2811
  27. Chen J, Mitra A, Li S, Song S, Nguyen B, Chen J, Shin J, Gough N, Lin P, Obias V, He A,Yao Z, Malta T, Noushmehr H, Latham P, Su X, ,Rashid A, Mishra B, Targeting the E3 ubiquitin ligase PJA1 enhances tumor-suppressing TGFβ signaling; Cancer Res., 2020, 80(9), pp. 1819–1832.
  28. White MG, Kothari A, Ikoma N, Murphy MB, Song S, Ajani J, Mansfield P, Badgwell B.White MG, et al. Factors Associated with Resection and Survival After Laparoscopic HIPEC for Peritoneal Gastric Cancer Metastasis Ann Surg Oncol. 2020 Dec;27(13):4963-4969.
  29. Zou J, Qin W, Yang L, Wang L, Wang Y, Shen J, Xiong W, Yu S, Song S, Ajani JA, Lin SY, Mills GB, Yuan X, Chen J, Peng G. Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer. Am J Cancer Res. 2020 Nov 1;10(11):3947-3972. PMID: 33294279
  30. Wang L, Yang L, Wang C, Zhao W, Ju Z, Zhang W, Shen J, Peng Y, An C, Luu YT, Song S, Yap TA, Ajani JA, Mills GB, Shen X, Peng G. Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. J Clin Invest. 2020 Nov 2;130(11):5951-5966. PMID: 33016929
  31. Li Y, Zhen N, Ajani JA and Song S*. Drug Resistance and Cancer Stem Cells. Review article. Cell Commun Signal. 2021 Feb 15;19(1):19. PMID: 33588867 *Corresponding authors.
  32. Chen B, Dragomir MP, Fabris L, Bayraktar R, Knutsen E, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, De Los Santos MC, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA. The Long Noncoding RNA CCAT2 induces             chromosomal instability through BOP1 - AURKB signaling. Gastroenterology. 2020;159(6):2146-2162. PubMed PMID: 32805281.
  33. Jin J, Song S* and Ajani JA*. Oncogenes Orchestrate Immunosuppressive Stroma in Gastric Adenocarcinoma. Review article. OBM Genetics; 2020, volume 4, issue 3;1-22. doi:10.21926/obm.genet.2003116. *Corresponding authors.
  34. Li F, Xu Y, Liu B, Jin JK, Zhao W, Scott A, Dong XC, Ma L, Pizzi MP, Wang Y, Harada K, Xie M, Skinner HD, Ding S, Johnson LR, Song S* and Ajani JA*. YAP1 mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer-Rationale for the combination of YAP1 and CDK4/6 inhibitors in Esophageal Cancer. Clin Can Res. 2019; 25: 2264-2277. PMID: 30563933. *Corresponding authors.
  35. Xu Y, Song S*, Wang Z, Ajani JA*. The role of hedgehog signaling in gastric cancer: molecular mechanisms, clinical potential, and perspective. Cell Commun Signal. 2019 Nov 27;17(1):157. *Corresponding authors.
  36. Yin Y, Liu W, Shen Q, Zhang P, Wang L, Tao R, Li H, Ma X, Zeng X, Cheong JH, Song S, Ajani JA, Mills GB, Tao K, Peng G. Yin Y, et al. The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer Mol Cancer Ther. 2019 Aug;18(8):1439-1450.
  37. Allen C, Newhook T, Vreeland T, Das P, Minsky B, Blum M, Song S, Ajani J, Ikoma N, Mansfield P, Roy-Chowdhuri S and Bagwell B; Yield of peritoneal cytology in staging patients with gastric and gastroesophageal cancer. Journal of Surgical Oncology, 2019, 120(8), 1350 - 1357
  38. Xu Y, Li Y, Jin J, Han G, Sun C, Pizzi MP, Huo L, Scott A, Wang Y, Ma L, Lee JH, Bhutani MS, Weston B, Vellano C, Yang L, Lin C, Kim Y, MacLeod AR, Wang L, Wang Z, Song S*, Ajani JA*. LncRNA PVT1 up-regulation is a poor prognosticator and serves as a therapeutic target in esophageal adenocarcinoma; Mol Cancer. 2019 Oct 10;18(1):141. *Corresponding authors.
  39. Song S, Xie M, Scott AW, Jin J, Ma L, Dong X, Skinner HD, Johnson RL, Ding S, Ajani JA. A Novel YAP1 Inhibitor targets CSCs-enriched Radiation Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma. Mol Cancer Ther 2018,17(2):443-454, PMCID: PMC5805581. *Corresponding author
  40. Zhao W, Ajani JA, Sushovan G, Ochi N, Hwang R, Hafley M, Johnson RL, Bresalier RS, Logsdon CD, Zhang Z, Song S*. Galectin-3 Mediates Tumor Cell-Stroma Interactions by Activating Pancreatic Stellate Cells to Produce Cytokines via Integrin Signaling. Gastroenterology. 2018 Apr;154(5):1524-1537 *Corresponding author
  41. Harada K, Dong X, Estrella JS, Correa AM, Xu Y, Hofstetter WL, Sudo K, Onodera H, Suzuki K, Suzuki A, Johnson RL, Wang Z, Song S*, Ajani JA*. Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma. Gastric Cancer. 2018 Jan; 21(1):31-40. Epub 2017 Aug 11. PubMed PMID: 28801853. *Corresponding author
  42. Ajani JA, Estrella JS, Chen Q, Correa AM, Ma L, Scott AW, Jin J, Liu B, Xie M, Sudo K, Shiozaki H, Badgwell B, Weston B, Lee JH, Bhutani MS, Onodera H, Suzuki K, Suzuki A, Ding S, Hofstetter WL, Johnson RL, Bresalier RS, Song S*. Galectin-3 expression is prognostic in diffuse type gastric adenocarcinoma, confers aggressive phenotype, and can be targeted by YAP1/BET inhibitors. Br J Cancer. 2018 Jan; 118 (1):52-61. PubMed PMID: 29136404; *Corresponding author
  43. Lopez A, Harada K, Mizrak Kaya D, Dong X, Song S, Ajani JA. Liquid biopsies in gastrointestinal malignancies: when is the big day? Expert Rev Anticancer Ther. 2018 Jan; 18(1):19-38. Epub 2017 Dec 4. Review. PubMed PMID: 29202614.
  44. Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, Jang HJ, Park ES, Kim SC, Heo J, Chu IS, Jang YJ, Mok YJ, Jung W, Kim BH,Kim A, Cho JY, Lim JY, Hayashi Y, Song S, Elimova E, Estralla JS, Lee JH, BhutaniMS, Lu Y, Liu W, Lee J, Kang WK, Kim S, Noh SH, Mills GB, Kim SY, Ajani JA, Lee JS. Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun. 2018 May 3;9(1):1777. doi: 10.1038/s41467-018-04179-8.
  45. Harada K, Song S, Ajani JA. Attenuation of YAP1 can potentially target cancer stem cells to overcome drug resistance. Oncoscience 2018; 5(7-8):214-215. e-Pub 8/2018. PMCID: PMC6142898.
  46. Vicente D, Ikoma N, Chiang YJ, Fournier K, Tzeng CD, Song S, Mansfield P, Ajani J, Badgwell BD. Preoperative Therapy for Gastric Adenocarcinoma is Protective for Poor Oncologic Outcomes in Patients with Complications After Gastrectomy. Ann Surg Oncol 25(9):2720-2730, 9/2018. e-Pub 7/2018. PMID: 29987602.
  47. Song S, Ajani JA. Reply. Gastroenterology 155(3):934-935, 9/2018. e-Pub 8/2018. PMID: 30098926.
  48. Harada K, Pool Pizzi M, Baba H, Shanbhag ND, Song S, Ajani JA. Cancer stem cells in esophageal cancer and response to therapy. Cancer 124(20):3962-3964, 10/2018. e-Pub 10/2018. PMCID: PMC6234092.
  49. Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G. ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nat Med. 2018;24(5):556-562. PubMed PMID: 29736026; PubMed Central PMCID: PMC6076433.
  50. Harada K, Kaya DM, Shimodaira Y, Song S, Baba H, Ajani JA. Translating genomic profiling to gastrointestinal cancer treatment. Future Oncol. 2017 Apr;13(10):919-934. PubMed PMID: 28067073.
  51. Wadhwa R, Wang X, Baladandayuthapani V, Liu B, Shiozaki H, Shimodaira Y, Lin Q, Elimova E, Hofstetter WL, Swisher SG, Rice DC, Maru DM, Kalhor N, Bhutani MS, Weston B, Lee JH, Skinner HD, Scott AW, Kaya DM, Harada K, Berry D, Song S, Ajani JA. Nuclear expression of Gli-1 is predictive of pathologic complete response to chemoradiation in trimodality treated oesophageal cancer patients. Br J Cancer.2017 Aug 22; 117 (5):648-655. PubMed PMID: 28728163; PubMed Central PMCID: PMC5572179.
  52. Harada K, Song S, Baba H, Ajani JA. Is phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway therapeutic target for esophageal adenocarcinoma. Shanghai Chest. 2017 Nov;1:51. doi: 10.21037/shc.2017.10.07. PMID: 30957072
  53. Mizrak Kaya D, Dong X, Nogueras-González GM, Xu Y, Estrella JS, Harada K, Lopez A, Amlashi FG, Hofstetter WL, Maru DM, Nguyen QN, Lee JH, Weston B, Bhutani MS, Erasmus JJ, Thomas I, Rogers JE, Song S, Ajani JA. Post-trimodality expression levels of metadherin (MTDH) as a prognostic biomarker for esophageal adenocarcinoma patients. Med Oncol. 2017 Aug; 34(8):135.
  54. Yin Y, Shen Q, Zhang P, Tao R, Chang W, Li R, Xie G, Liu W, Zhang L, Kapoor P, Song S, Ajani J, Mills GB, Chen J, Tao K, Peng G. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am J Cancer Res. 2017 Mar 1;7(3):473-483. PubMed PMID: 28401005; PubMed Central PMCID: PMC5385637.
  55. Elimova E, Lin Q, Song S, Ajani JA. Current status of ramucirumab in gastroesophageal adenocarcinoma. Future Oncol. 2017 Aug; 13(18):1585-1592. PubMed PMID: 28436242.
  56. Ajani JA, Lee J, Sano T, Janjigian YY, Fan D, Song S. Gastric adenocarcinoma. Nat Rev Dis Primers. 2017 Jun 1;3:17036. Review. PubMed PMID: 28569272.
  57. Ohtsuka M, Ling H, Ivan C, Pichler M, Matsushita D, Goblirsch M, Stiegelbauer V, Shigeyasu K, Zhang X, Chen M, Vidhu F, Bartholomeusz GA, Toiyama Y, Kusunoki M, Doki Y, Mori M, Song S, Gunther JR, Krishnan S, Slaby O, Goel A, Ajani JA, Radovich M, Calin GA.. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer EBioMedicine. 2016;13:113-124. PMID: 27789274
  58. Yi J, Lu L, Yanger K, Wang W, Sohn BH, Stanger BZ, Zhang M, Martin JF, Ajani JA, Chen J, Lee JS, Song S, Johnson RL. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology. 2016 Nov; 64(5):1757-1772. doi: 10.1002/hep.28768. PubMed PMID: 27531557.
  59. Elimova E, Song S, Shimodaira Y, Lin Q, Ajani JA. Exploiting Molecular and Immune Biology of Gastric and Gastroesophageal Adenocarcinomas to Discover Novel Therapeutic Targets. Ann Surg Oncol. 2016 Nov; 23(12):3786-3791. PubMed PMID: 27503493.
  60. Harada K, Mizrak Kaya D, Shimodaira Y, Song S, Baba H, Ajani JA. Proteomics approach to identify biomarkers for upper gastrointestinal cancer. Expert Rev Proteomics. 2016 Nov;13(11):1041-1053. doi: 10.1080/14789450.2016.1246189. PMID: 27718753
  61. Song S*,Honjo S, Jin JK, Chang SS, Scott AW, Chen QR, Kalhor N, Correa AM, Hofstetter WL, Albarracin CT, Wu TT, Johnson RL, Hung MC, Ajani JA. The Hippo coactivator YAP mediates EGFR overexpression and confers chemo-resistance in esophageal cancer. Clin Cancer Res. 2015; 21(11):2580-90. PMID: 25739674; PMCID: PMC4452384. *Corresponding author
  62. Ajani JA, Song S and Hochster HS. Cancer Stem Cells: The Promise & The Potential Review, Seminars in Oncology, 2015; 42 Suppl 1:S3-17. PMID: 25839664.
  63. Ajani JA, Song S, Hochster HS, Steinberg IB. Introduction. Semin Oncol 42 Suppl 1:S1-2, 4/2015. e-Pub 2/2015. PMID: 25839663.
  64. Shimodaira Y, Elimova E, Wadhwa R, Shiozaki H, Charalampakis N, Planjery V, Rogers JE, Song S, Ajani JA. Ramucirumab for the treatment of gastroesophageal cancers. Expert Opin Orphan Drugs. 2015; 3(6):737-746. PubMed PMID: 27570714; PubMed Central PMCID: PMC5001688.
  65. Elimova E, Wadhwa R, Shiozaki H, Sudo K, Estrella JS, Badgwell BD, Das P, Matamoros A Jr, Song S, Ajani JA. Molecular biomarkers in gastric cancer. J Natl Compr Canc Netw. 2015 Apr; 13(4):e19-29. PubMed PMID: 26052595.
  66. Chen Q, Song S*, Wei SZ, Liu B, Honjo S, Scott AW; Jin JK, Ma L, Zhu Z, Skinner H, Johnson RL, and Ajani JA* ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer. Oncotarget.2015 Sep 22;6(28):25883-96. doi: 10.18632/oncotarget.4540. PubMed PMID: 26317542 *Corresponding author
  67. Ajani JA, Wang X, Song S, Suzuki A, Taketa T, Sudo K, Wadhwa R, Hofstetter WL, Komaki R, Maru DM, Lee JH, Bhutani MS, Weston B, Baladandayuthapani V, Yao Y, Honjo S, Scott AW, Skinner HD, Johnson RL, Berry D. ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients. Mol Oncol. 2014; 8(1):142-9.
  68. Wadhwa R, Elimova E, Shiozaki H, Sudo K, Blum MA, Estrella JS, Chen Q, Song S, Ajani JA. Anti-angiogenic agent ramucirumab: meaningful or marginal? Expert Rev Anticancer Ther. 2014; 14(4):367-79. PubMed PMID: 24605771.
  69. Honjo S, Ajani JA, Scott AW, Chen Q, Skinner HD, Stroehlein J, Johnson RL, Song S*. Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer. Int J Oncol. 2014 Aug; 45(2):567-74. PubMed PMID: 24859412. * Corresponding author
  70. Skinner H, Lee,JH, Bhutan M,  Weston B,  Hofstetter W,  Komaki R, Shiozak H,  Wadhwa R,  Sudo K,  Elimova E, Song S, Ye Y,  Huang M,  Ajani J,  Wu X. A validated miRNA profile predicts response to therapy in esophageal adenocarcinoma. Cancer, 2014; 120(23):3635-41.  PMID: 25091571.
  71. Song S*, Ajani JA, Honjo S, Maru DM, Chen Q, Scott AW, Heallen TR, Xiao L, Hofstetter WL, Weston B, Lee JH, Wadhwa R, Sudo K, Stroehlein JR, Martin JF, Hung MC, Johnson RL. Hippo Coactivator YAP1 Upregulates SOX9 and Endows Esophageal Cancer Cells with Stem-like Properties. Cancer Res. 2014 Aug 1; 74(15):4170-82. *Corresponding author
  72. Li Y, Liu Z, Liu H, Wang LE, Onodera H, Suzuki A, Suzuki K, Wadhwa R, Elimova E, Sudo K, Shiozaki H, Estrella J, Lee JS, Song S, Tan D, Ajani JA, Wei Q. Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients. Carcinogenesis. 2014 Sep; 35(9):2031-8. PubMed PMID: 24990617
  73. Elimova E, Shiozaki H, Wadhwa R, Sudo K, Chen Q, Estrella JS, Blum MA, Badgwell B, Das P, Song S, Ajani JA. Medical management of gastric cancer: a 2014 update. World J Gastroenterol. 2014 Oct 14; 20(38):13637-47. PMCID: PMC4194548.
  74. Elimova E, Song S, and Ajani JA. EGFR as a Therapeutic Target for Gastroesophageal Cancer—or Is It Really? ACSO post. 2014, Volume 5, Issue 13
  75. Ajani JA, Wang X, Song S, Suzuki A, Taketa T, Sudo K, Wadhwa R, Hofstetter WL, Komaki R, Maru DM, Lee JH, Bhutani MS, Weston B, Baladandayuthapani V, Yao Y, Honjo S, Scott AW, Skinner HD, Johnson RL, Berry D. ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients; Mol Oncol. 2014 Feb;8(1):142-9. PMID: 24210755.
  76. Song S, Ajani JA. The role of microRNAs in cancers of the upper gastrointestinal tract. Nat Rev Gastroenterol Hepatol 2013; 10(2):109-18. PMID: 23165235.
  77. Song S*, Maru DM, Ajani JA, Chan CH, Honjo S, Lin HK, Correa A, Hofstetter WL, Davila M, Stroehlein J, Mishra L. Loss of TGF-β adaptor β2SP activates notch signaling and SOX9 expression in esophageal adenocarcinoma. Cancer Res 2013; 73(7):2159-69. PMCID: PMC3745222. *corresponding author
  78. Wadhwa R, Song S, Yao Y, Lee J-S, Wei Q and Ajani JA. Gastric Cancer: Molecular and Clinical Dimensions. Nature Reviews Clinical Oncology; 2013;10(11):643-55.
  79. Song S, Ji B, Ramachandran V, Wang H, Hafley M, Logsdon C, Bresalier RS. Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding ras and activating ras signaling. PLoS One 2012; 7(8):e42699. PMCID: PMC3416861. *corresponding author.
  80. Song S, Byrd JC, Guha S, Liu KF, Koul D, Bresalier RS. Induction of MUC5AC mucin by conjugated bile acids in the esophagus involves the phosphatidylinositol 3-kinase/protein kinase C/activator protein-1 pathway. Cancer. 2011; 117(11):2386-97; PMID: 24048786; PMCID: PMC3116027.
  81. Mendelson J, Song S, Li Y, Maru DM, Mishra B, Davila M, Hofstetter WL, Mishra L. Dysfunctional transforming growth factor-β signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma. Cancer 2011; 117(16):3691-702. PMCID: PMC3236645.
  82. Song S, Mishra L. Reply to dysfunctional transforming growth factor-β signaling with constitutively active notch signaling in Barrett's esophageal adenocarcinoma. Cancer. 2011; Sept 6 e-Pub PMID: 21898378.
  83. Song S, Krishnan K, Liu K, Bresalier RS. Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression. Clin Cancer Res 2009; 15(2):622-31. PMID: 19147768.
  84. Song S, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K, Hung MC, Bresalier RS. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3 beta activity. Cancer Res 2009; 69(4):1343-9. PMID: 19190323.
  85. Song S, Guan B, Men T, Hoque A, Lotan R, Xu XC. Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2. Cancer Prev Res (Phila Pa) 2009; 2(3):274-80. PMID: 19258542.
  86. Song S, Guha S, Liu KF, Buttar NS, Bresalier RS. Induction of COX-2 by unconjugated bile acids involves reactive oxygen species-mediated signaling pathway in the esophagus. Gut 2007; 56:1512-1521.PMID:17604323.
  87. Song S, Byrd JC, Koo JS, Bresalier RS. Bile acids induce MUC2 overexpression in human colon carcinoma cells. 2005; Cancer 103(8):1606-14. PMID: 15754327.
  88. Song S, Byrd JC, Mazurek N, Liu K, Koo JS, Bresalier RS. Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation. Gastroenterology 2005; 129(5):1581-91. PMID: 16285957.
  89. Song S, Lippman SM, Zou Y, Ye X, Ajani JA, Xu XC. Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression. Oncogene 2005; 24(56):8268-76. PMID: 16170369.
  90. Jiang B, Liu W, Qu H, Meng L, Song S, Quyang T,Shou C. A novel peptide isolated from a phage display peptide library with Trastuzumab can mimic antigen epitope of HER2. The Journal of Biological Chemistry 2005; 280 (6):4656-4662.
  91. An P, Lei H, Zhang J, Song S, He L, Jin G, Liu X, Wu J, Meng L, Liu M, Shou C. Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library. Int J Cancer 2004; 111(2):165-73. PMID: 15197767.
  92. Xu XC, Shappell SB, Liang Z, Song S, Menter D, Subbarayan V, Iyengar S, Tang DG, Lippman SM. Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398. Neoplasia 2003; 5(2):121-7. PMID: 12659684.
  93. Li M, Song S, Lippman SM, Zhang XK, Liu X, Lotan R, Xu XC. Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. Oncogene 2002; 21(3):411-8. PMID: 11821953.
  94. Lei H, An P, Song S, Liu X, He L, Wu J, Meng L, Liu M, Yang J, Shou C. A Novel Peptide Isolated from a Phage Display Library Inhibits Tumor Growth and Metastasis by Blocking the Binding of Vascular Endothelial Growth factor to its Kinase Domain Receptor. J. Bio Chem. 2002; 277:43137-43142.
  95. Song S, Xu XC. Effect of benzo[a]pyrene diol epoxide on expression of retinoic acid receptor-beta in immortalized esophageal epithelial cells and esophageal cancer cells. Biochem Biophys Res Commun 2001; 281(4):872-7. PMID: 11237740.
  96. Tian X, Song S, Wu J, Meng L, Dong Z, Shou C. Vascular endothelial growth factor: acting as an autocrine growth factor for human gastric adenocarcinoma cell MGC803. Biochem Biophys Res Commun 2001; 286(3):505-12. PMID: 11511087.
  97. Song S, Wu J, Shou C. Inhibition of Monoclonal Antibodies against Extracellular I-IV domains of Vascular Endothelial Cell Growth Factor Receptor KDR on the Proliferation EC and Formation of Chicken embryo blood Vessels. Chin J Microbiol Immunol 2000; 20(4):327-330.
  98. Song S, Shou C. Inhibition of prokaryotic expressed soluble KDR receptor on activity of Vascular Endothelial Growth Factor. Natl Med J China 2000; 80:226-227.
  99. Song S, Shou C. Cloning and Expression of Truncated KDR Binding to Vascular Endothelial Growth. Prog. Biochem. Biophys. 1999; 26:481-484.
  100. Song S, Zeng L, et al. Cloning and McAb Preparation of VEGF Receptor KDR Extracellular V-VII domains and its expression in Different Originated Tumors. Chinese Journal of Oncology1999; 21:96-98.
  101. Song S, Wu J, Shou C. Expression of VEGF Receptor II, KDR, in Different Originated Carcinoma. Chinese Journal of Cancer Research 1998;10(3):104-108.
  102. Song S, Shou C. Molecular cloning and prokaryotic expression of Vascular Endothelial Growth Factor Receptor KDR. Journal of Chinese Biochemistry and Molecular Biology 1998; 14:57-6.
  103. Song S, Wu J, Shou C. The Preparation and Identification of Monoclonal Antibodies against Vascular endothelial Cell Growth Factor Receptor (KDR) Journal of Beijing Medical University 1998;30:509-511.
  104. Song S, Shou C. Molecular-biology research progression of VEGF and VEGF receptor. Foreign Medical Molecular Biology Fascicle 1997;19:245-250.
  105. Song S Shou C. Telomerase---the new target for cancer therapy. Foreign Medical Oncology Fascicle 1997;17:86-89.
  106. Song S et al. Examination of HSV-2 antigen in autoplastic cervical cancer and proliferated tissue in mice. Cancer Research of Prevention and Treatment 1995; 22(3):144-145.
  107. Song S, Chen M. Cancer of autoplastic cervix and vagina induced with Herpes Simplex Virus type2 in mice. Journal China Experimental and clinical Virology1992; 6:227-232.
  108. Zhang Y, Song S, et al. Development of desmin and its role for tumor distinguished diagnosis. Cancer Research of Prevention and Treatment 1992;19(2):24-28.
  109. Li J, Song S. LAK cells from abdominal ascites treating a case of hepatic cancer. Cancer Research of Prevention and Treatment 1994; 21:98-99.