Entry
Symbol
FDPS
Name
Pathway
map00900 Terpenoid backbone biosynthesis
map01110 Biosynthesis of secondary metabolites
map05166 Human T-cell leukemia virus 1 infection
Module
M00366 C10-C20 isoprenoid biosynthesis, plants
M00367 C10-C20 isoprenoid biosynthesis, non-plant eukaryotes
Reaction
R01658 dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase
R02003 geranyl-diphosphate:isopentenyl-diphosphate geranyltrans-transferase
Disease
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09109 Metabolism of terpenoids and polyketides
00900 Terpenoid backbone biosynthesis
K00787 FDPS; farnesyl diphosphate synthase
09160 Human Diseases
09172 Infectious disease: viral
05166 Human T-cell leukemia virus 1 infection
K00787 FDPS; farnesyl diphosphate synthase
05164 Influenza A
K00787 FDPS; farnesyl diphosphate synthase
09180 Brite Hierarchies
09181 Protein families: metabolism
01006 Prenyltransferases
K00787 FDPS; farnesyl diphosphate synthase
Enzymes [BR:ko01000 ]
2. Transferases
2.5 Transferring alkyl or aryl groups, other than methyl groups
2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
2.5.1.1 dimethylallyltranstransferase
K00787 FDPS; farnesyl diphosphate synthase
2.5.1.10 (2E,6E)-farnesyl diphosphate synthase
K00787 FDPS; farnesyl diphosphate synthase
Prenyltransferases [BR:ko01006 ]
Terpene biosynthesis
Prenyl diphosphate synthase
K00787 FDPS; farnesyl diphosphate synthase
BRITE hierarchy
Other DBs
Genes
» show all
Taxonomy UniProt
Reference
Authors
Vandermoten S, Haubruge E, Cusson M
Title
New insights into short-chain prenyltransferases: structural features, evolutionary history and potential for selective inhibition.
Journal
Reference
Authors
Cunillera N, Arro M, Delourme D, Karst F, Boronat A, Ferrer A
Title
Arabidopsis thaliana contains two differentially expressed farnesyl-diphosphate synthase genes.
Journal
Reference
Authors
Wilkin DJ, Kutsunai SY, Edwards PA
Title
Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester.
Journal
J Biol Chem 265:4607-14 (1990)
Sequence
LinkDB
All DBs