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ONTOLOGY REPORT - ANNOTATIONS

Term:protein-lysine N-methyltransferase activity
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Accession:GO:0016279 term browser browse the term
Definition:Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate.
Synonyms:exact_synonym: protein (lysine) methyltransferase activity;   protein lysine methylase activity
 xref: RHEA:51736;   reactome:R-HSA-212263 "PRC2 trimethylates histone H3 at lysine-27";   reactome:R-HSA-8865237 "SETD6 methylates RELA in the NFkB complex";   reactome:R-HSA-8931858 "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB";   reactome:R-HSA-8931974 "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A";   reactome:R-HSA-8932221 "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8";   reactome:R-HSA-8932243 "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2";   reactome:R-HSA-8932275 "METTL22 transfers 3xCH3 from 3xAdoMet to KIN";   reactome:R-HSA-8932276 "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP";   reactome:R-HSA-8932413 "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1"


show annotations for term's descendants           Sort by:
protein-lysine N-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Antkmt adenine nucleotide translocase lysine methyltransferase enables ISO
IBA		 (PMID:31213526)
GO_REF:0000033		 RGD
GO_Central		 PMID:31213526 GO_REF:0000033 NCBI chr10:14,812,274...14,814,798
Ensembl chr10:14,812,269...14,814,193 		JBrowse link
G Atpsckmt ATP synthase c subunit lysine N-methyltransferase enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:30530489)
GO_REF:0000033
(PMID:29444090), (PMID:30530489)		 UniProt
RGD
GO_Central		 PMID:29444090 PMID:30530489 GO_REF:0000024 GO_REF:0000033 NCBI chr 2:82,603,086...82,618,325
Ensembl chr 2:82,603,009...82,618,308 		JBrowse link
G Eef1akmt1 EEF1A lysine methyltransferase 1 enables ISO (PMID:26545399) RGD PMID:26545399 NCBI chr15:31,694,284...31,711,367
Ensembl chr15:31,694,292...31,711,336 		JBrowse link
G Eef1akmt2 EEF1A lysine methyltransferase 2 enables ISO (PMID:25144183) RGD PMID:25144183 NCBI chr 1:187,616,156...187,640,934
Ensembl chr 1:187,500,744...187,640,937 		JBrowse link
G Eef1akmt3 EEF1A lysine methyltransferase 3 enables ISO
IBA		 (PMID:28108655), (PMID:28663172)
GO_REF:0000033		 RGD
GO_Central		 PMID:28108655 PMID:28663172 GO_REF:0000033 NCBI chr 7:62,853,304...62,864,558
Ensembl chr 7:62,854,899...62,864,617 		JBrowse link
G Eef1akmt4 EEF1A lysine methyltransferase 4 enables ISO (PMID:28520920) RGD PMID:28520920 NCBI chr11:80,292,113...80,299,670
Ensembl chr11:80,291,978...80,299,659 		JBrowse link
G Eef2kmt eukaryotic elongation factor 2 lysine methyltransferase enables ISO
IBA		 (PMID:25231979)
GO_REF:0000033		 RGD
GO_Central		 PMID:25231979 GO_REF:0000033 NCBI chr10:10,336,933...10,349,463
Ensembl chr10:10,336,974...10,347,039 		JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 enables ISO (PMID:20118233) RGD PMID:20118233 NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 enables ISO (PMID:19144645), (PMID:20118233) RGD PMID:19144645 PMID:20118233 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Etfbkmt electron transfer flavoprotein subunit beta lysine methyltransferase enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:25023281)
GO_REF:0000033
(PMID:25023281), (PMID:25416781)		 UniProt
RGD
GO_Central		 PMID:25023281 PMID:25416781 GO_REF:0000024 GO_REF:0000033 NCBI chr 4:182,140,492...182,204,635
Ensembl chr 4:182,140,559...182,150,305 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit enables ISO (PMID:19144645)
(PMID:25547114)		 RGD PMID:19144645 PMID:25547114 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Kmt5a lysine methyltransferase 5A enables ISO (PMID:17707234) RGD PMID:17707234 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711 		JBrowse link
G Mettl13 methyltransferase 13, eEF1A N-terminus and K55 enables ISO (PMID:30143613) RGD PMID:30143613 NCBI chr13:74,886,151...74,899,937
Ensembl chr13:74,886,155...74,899,870 		JBrowse link
G Mettl21a methyltransferase 21A, HSPA lysine enables ISO
IBA		 (PMID:22948820), (PMID:23921388)
GO_REF:0000033		 RGD
GO_Central		 PMID:22948820 PMID:23921388 GO_REF:0000033 NCBI chr 9:65,934,253...65,999,964
Ensembl chr 9:65,978,051...65,987,550 		JBrowse link
G Mettl21c methyltransferase 21C, AARS1 lysine enables ISO
IBA		 (PMID:22948820), (PMID:32611769)
GO_REF:0000033
(PMID:32611769)		 RGD
GO_Central		 PMID:22948820 PMID:32611769 GO_REF:0000033 NCBI chr 9:46,130,451...46,145,128
Ensembl chr 9:46,134,001...46,145,112 		JBrowse link
G Mettl21cl1 methyltransferase like 21C-like 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 9:46,382,141...46,397,299
Ensembl chr 9:46,383,687...46,397,266 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase enables ISO (PMID:28753426) RGD PMID:28753426 NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489 		JBrowse link
G Setd3 SET domain containing 3, actin N3(tau)-histidine methyltransferase NOT|enables ISO (PMID:30785395) RGD PMID:30785395 NCBI chr 6:127,023,058...127,090,020
Ensembl chr 6:127,023,058...127,090,008 		JBrowse link
G Setd6 SET domain containing 6, protein lysine methyltransferase enables ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:21131967), (PMID:21515635), (PMID:23324626), (PMID:30189201)		 UniProt
GO_Central
RGD		 PMID:21131967 PMID:21515635 PMID:23324626 PMID:30189201 GO_REF:0000024 GO_REF:0000033 NCBI chr19:9,343,309...9,350,477
Ensembl chr19:9,347,458...9,350,453 		JBrowse link
G Setd7 SET domain containing 7, histone lysine methyltransferase enables ISO
IBA		 (PMID:16415881), (PMID:17108971), (PMID:35210392)
GO_REF:0000033
(PMID:23509280), (PMID:27292644), (PMID:35210392)		 RGD
GO_Central		 PMID:16415881 PMID:17108971 PMID:23509280 PMID:27292644 PMID:35210392 GO_REF:0000033 NCBI chr 2:135,562,683...135,605,468
Ensembl chr 2:135,562,683...135,605,468 		JBrowse link
G Smyd2 SET and MYND domain containing 2 enables ISS
ISO		 GO_REF:0000024
(PMID:17108971), (PMID:20870719)		 UniProt
RGD		 PMID:17108971 PMID:20870719 GO_REF:0000024 NCBI chr13:101,425,270...101,466,576
Ensembl chr13:101,425,273...101,466,576 		JBrowse link
G Smyd5 SMYD family member 5 enables ISO (PMID:39048817), (PMID:39103523) RGD PMID:39048817 PMID:39103523 NCBI chr 4:117,969,615...117,984,082
Ensembl chr 4:117,969,626...117,984,347 		JBrowse link
G Vcpkmt valosin containing protein lysine methyltransferase enables ISO (PMID:22948820), (PMID:23349634) RGD PMID:22948820 PMID:23349634 NCBI chr 6:88,036,485...88,042,151
Ensembl chr 6:88,036,494...88,042,000 		JBrowse link
calmodulin-lysine N-methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camkmt calmodulin-lysine N-methyltransferase enables IEA
ISO
IBA		 GO_REF:0000003
(PMID:26247364)
GO_REF:0000033		 UniProt
RGD
GO_Central		 PMID:26247364 GO_REF:0000003 GO_REF:0000033 NCBI chr 6:9,198,945...9,580,200
Ensembl chr 6:9,198,947...9,580,242 		JBrowse link
histone H3K27 dimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsd3 nuclear receptor binding SET domain protein 3 enables ISO (PMID:16682010) RGD PMID:16682010 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423 		JBrowse link
histone H3K27 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ehmt1 euchromatic histone lysine methyltransferase 1 enables ISO (PMID:15774718) RGD PMID:15774718 NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 enables ISO (PMID:15774718), (PMID:17212651) RGD PMID:15774718 PMID:17212651 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit enables ISO
IBA		 (PMID:33514705)
GO_REF:0000033
(PMID:19303854)		 RGD
GO_Central		 PMID:19303854 PMID:33514705 GO_REF:0000033 NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit enables ISO
IBA		 (PMID:15385962), (PMID:22323599), (PMID:28229514), (PMID:30026490), (PMID:30923826)
GO_REF:0000033
(PMID:16717091)		 RGD
GO_Central		 PMID:15385962 PMID:16717091 PMID:22323599 PMID:28229514 PMID:30026490 More... GO_REF:0000033 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Jarid2 jumonji and AT-rich interaction domain containing 2 NOT|contributes_to ISO (PMID:20064375)
(PMID:20064376)		 RGD PMID:20064375 PMID:20064376 NCBI chr17:19,777,487...19,957,696
Ensembl chr17:19,777,266...19,955,690 		JBrowse link
G Nsd3 nuclear receptor binding SET domain protein 3 enables ISO (PMID:16682010) RGD PMID:16682010 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423 		JBrowse link
histone H3K27 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ezh1 enhancer of zeste 1 polycomb repressive complex 2 subunit enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr10:86,126,023...86,162,001
Ensembl chr10:86,126,015...86,161,921 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362 		JBrowse link
G Nsd3 nuclear receptor binding SET domain protein 3 enables ISO (PMID:16682010) RGD PMID:16682010 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423 		JBrowse link
histone H3K36 dimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Setmar SET domain and mariner transposase fusion gene enables ISS
ISO		 GO_REF:0000024
(PMID:16332963)		 UniProt
RGD		 PMID:16332963 GO_REF:0000024 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
G Smyd3 SET and MYND domain containing 3 enables ISO (PMID:16805913) RGD PMID:16805913 NCBI chr13:90,709,263...91,266,209
Ensembl chr13:90,709,270...91,266,253 		JBrowse link
histone H3K36 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ash1l ASH1 like histone lysine methyltransferase enables ISO (PMID:26002201) RGD PMID:26002201 NCBI chr 2:174,346,267...174,483,057
Ensembl chr 2:174,346,150...174,483,055 		JBrowse link
G Nsd1 nuclear receptor binding SET domain protein 1 enables ISO
IBA		 (PMID:20837538), (PMID:21196496)
(PMID:12805229)
GO_REF:0000033		 RGD
GO_Central		 PMID:12805229 PMID:20837538 PMID:21196496 GO_REF:0000033 NCBI chr17:9,311,963...9,426,373
Ensembl chr17:9,315,237...9,425,358 		JBrowse link
G Nsd2 nuclear receptor binding SET domain protein 2 enables ISO
IBA		 (PMID:24595546), (PMID:33941880)
GO_REF:0000033		 RGD
GO_Central		 PMID:24595546 PMID:33941880 GO_REF:0000033 NCBI chr14:76,833,179...76,911,304
Ensembl chr14:76,835,637...76,913,641 		JBrowse link
G Nsd3 nuclear receptor binding SET domain protein 3 enables ISO
IBA		 (PMID:21555454)
GO_REF:0000033		 RGD
GO_Central		 PMID:21555454 GO_REF:0000033 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423 		JBrowse link
G Prdm9 PR/SET domain 9 enables ISS
ISO
IBA		 GO_REF:0000024
(PMID:27362481)
GO_REF:0000033
(PMID:24634223)		 UniProt
RGD
GO_Central		 PMID:24634223 PMID:27362481 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase enables ISO
IBA		 (PMID:19141475), (PMID:23043551), (PMID:23325844), (PMID:23622243), (PMID:24843002), (PMID:26002201), (PMID:27474439), (PMID:28753426)
MGI:4437211 (PMID:18157086), (PMID:20133625), (PMID:24036311), (PMID:25242323)
GO_REF:0000033		 RGD
GO_Central		 PMID:18157086 PMID:19141475 PMID:20133625 PMID:23043551 PMID:23325844 More... GO_REF:0000033 NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489 		JBrowse link
G Setd3 SET domain containing 3, actin N3(tau)-histidine methyltransferase enables IBA
ISO		 GO_REF:0000033
(PMID:21832073)		 GO_Central
RGD		 PMID:21832073 GO_REF:0000033 NCBI chr 6:127,023,058...127,090,020
Ensembl chr 6:127,023,058...127,090,008 		JBrowse link
G Setd4 SET domain containing 4 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr11:32,829,509...32,859,162
Ensembl chr11:32,838,063...32,858,243 		JBrowse link
G Setd5 SET domain containing 5 enables ISO (PMID:31515109) RGD PMID:31515109 NCBI chr 4:146,217,172...146,294,896
Ensembl chr 4:146,217,180...146,294,894 		JBrowse link
G Setmar SET domain and mariner transposase fusion gene enables ISO (PMID:21187428), (PMID:22231448) RGD PMID:21187428 PMID:22231448 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
G Smyd2 SET and MYND domain containing 2 enables ISS
ISO		 GO_REF:0000024
(PMID:16805913), (PMID:22862948)		 UniProt
RGD		 PMID:16805913 PMID:22862948 GO_REF:0000024 NCBI chr13:101,425,270...101,466,576
Ensembl chr13:101,425,273...101,466,576 		JBrowse link
histone H3K36 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsd2 nuclear receptor binding SET domain protein 2 enables ISO (PMID:19483677) RGD PMID:19483677 NCBI chr14:76,833,179...76,911,304
Ensembl chr14:76,835,637...76,913,641 		JBrowse link
G Prdm9 PR/SET domain 9 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652 		JBrowse link
G Setd2 SET domain containing 2, histone lysine methyltransferase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:110,511,808...110,597,475
Ensembl chr 8:110,511,772...110,597,489 		JBrowse link
G Smyd5 SMYD family member 5 enables IEA
ISO		 GO_REF:0000107
(PMID:35680905), (PMID:39083378)		 Ensembl
RGD		 PMID:35680905 PMID:39083378 GO_REF:0000107 NCBI chr 4:117,969,615...117,984,082
Ensembl chr 4:117,969,626...117,984,347 		JBrowse link
histone H3K37 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
histone H3K4 dimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsd3 nuclear receptor binding SET domain protein 3 enables ISO (PMID:16682010) RGD PMID:16682010 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423 		JBrowse link
histone H3K4 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ash1l ASH1 like histone lysine methyltransferase enables IBA
ISO		 GO_REF:0000033
(PMID:24012418)		 GO_Central
RGD		 PMID:24012418 GO_REF:0000033 NCBI chr 2:174,346,267...174,483,057
Ensembl chr 2:174,346,150...174,483,055 		JBrowse link
G Kmt2a lysine methyltransferase 2A enables ISO
IBA		 (PMID:15960975), (PMID:19187761), (PMID:19556245), (PMID:22012064), (PMID:24235145)
MGI:3839794 (PMID:12453418), (PMID:16618927), (PMID:21113167), (PMID:25834037)
GO_REF:0000033		 RGD
GO_Central		 PMID:12453418 PMID:15960975 PMID:16618927 PMID:19187761 PMID:19556245 More... GO_REF:0000033 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Kmt2b lysine methyltransferase 2B enables ISO
IBA		 (PMID:17166833), (PMID:17500065)
MGI:3056522|MGI:3623309 (PMID:20808952), (PMID:33766931)
GO_REF:0000033		 RGD
GO_Central		 PMID:17166833 PMID:17500065 PMID:20808952 PMID:33766931 GO_REF:0000033 NCBI chr 1:85,821,700...85,840,987
Ensembl chr 1:85,821,753...85,841,326 		JBrowse link
G Kmt2c lysine methyltransferase 2C enables ISO (PMID:17500065)
(PMID:18172164)		 RGD PMID:17500065 PMID:18172164 NCBI chr 4:9,620,638...9,834,787
Ensembl chr 4:9,609,627...9,833,539 		JBrowse link
G Kmt2d lysine methyltransferase 2D enables ISO (PMID:20808952) RGD PMID:20808952 NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325 		JBrowse link
G Nsd3 nuclear receptor binding SET domain protein 3 enables ISO (PMID:16682010) RGD PMID:16682010 NCBI chr16:66,354,030...66,466,202
Ensembl chr16:66,358,973...66,465,423 		JBrowse link
G Prdm9 PR/SET domain 9 enables ISO
IBA
ISS		 (PMID:24095733), (PMID:24634223), (PMID:26833727)
(PMID:16292313), (PMID:22028627), (PMID:24095733), (PMID:27362481), (PMID:32374261)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:16292313 PMID:22028627 PMID:24095733 PMID:24634223 PMID:26833727 More... GO_REF:0000024 GO_REF:0000033 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652 		JBrowse link
G Setbp1 SET binding protein 1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:72,190,542...72,551,272
Ensembl chr18:72,191,035...72,552,556 		JBrowse link
G Setd1a SET domain containing 1A, histone lysine methyltransferase enables ISO
IBA		 (PMID:20862685)
MGI:5568936 (PMID:24550110), (PMID:29490266)
GO_REF:0000033		 RGD
GO_Central		 PMID:20862685 PMID:24550110 PMID:29490266 GO_REF:0000033 NCBI chr 1:182,386,197...182,411,695
Ensembl chr 1:182,388,060...182,411,090 		JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase contributes_to
enables		 ISO
IBA		 (PMID:17355966)
GO_REF:0000033		 RGD
GO_Central		 PMID:17355966 GO_REF:0000033 NCBI chr12:33,395,963...33,421,671
Ensembl chr12:33,396,120...33,426,934 		JBrowse link
G Setd3 SET domain containing 3, actin N3(tau)-histidine methyltransferase enables IBA
ISO		 GO_REF:0000033
(PMID:21832073)		 GO_Central
RGD		 PMID:21832073 GO_REF:0000033 NCBI chr 6:127,023,058...127,090,020
Ensembl chr 6:127,023,058...127,090,008 		JBrowse link
G Setd4 SET domain containing 4 enables IBA
ISO		 GO_REF:0000033
(PMID:31376731)		 GO_Central
RGD		 PMID:31376731 GO_REF:0000033 NCBI chr11:32,829,509...32,859,162
Ensembl chr11:32,838,063...32,858,243 		JBrowse link
G Setmar SET domain and mariner transposase fusion gene enables ISS
ISO		 GO_REF:0000024
(PMID:16332963)		 UniProt
RGD		 PMID:16332963 GO_REF:0000024 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
G Smyd1 SET and MYND domain containing 1 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:103,195,330...103,252,989
Ensembl chr 4:103,200,322...103,311,766 		JBrowse link
G Wdr5 WD repeat domain 5 enables IEA
ISO		 GO_REF:0000107
(PMID:24051374)		 Ensembl
RGD		 PMID:24051374 GO_REF:0000107 NCBI chr 3:10,836,964...10,856,682
Ensembl chr 3:10,837,025...10,856,671 		JBrowse link
histone H3K4 monomethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmt2a lysine methyltransferase 2A enables IEA GO_REF:0000116 RHEA GO_REF:0000116 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Setd7 SET domain containing 7, histone lysine methyltransferase enables IEA GO_REF:0000003
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000003 NCBI chr 2:135,562,683...135,605,468
Ensembl chr 2:135,562,683...135,605,468 		JBrowse link
histone H3K4 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmt2a lysine methyltransferase 2A enables ISO (PMID:20861184) RGD PMID:20861184 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181 		JBrowse link
G Kmt2b lysine methyltransferase 2B enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:85,821,700...85,840,987
Ensembl chr 1:85,821,753...85,841,326 		JBrowse link
G Kmt2d lysine methyltransferase 2D enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325 		JBrowse link
G Prdm9 PR/SET domain 9 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652 		JBrowse link
G Setd1b SET domain containing 1B, histone lysine methyltransferase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:33,395,963...33,421,671
Ensembl chr12:33,396,120...33,426,934 		JBrowse link
G Smyd2 SET and MYND domain containing 2 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr13:101,425,270...101,466,576
Ensembl chr13:101,425,273...101,466,576 		JBrowse link
histone H3K56 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 enables ISO (PMID:22387026) RGD PMID:22387026 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
histone H3K79 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dot1l DOT1 like histone lysine methyltransferase enables IBA
ISO		 GO_REF:0000033
(PMID:15851025)		 GO_Central
RGD		 PMID:15851025 GO_REF:0000033 NCBI chr 7:8,918,764...8,959,474
Ensembl chr 7:8,917,786...8,956,475 		JBrowse link
histone H3K79 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dot1l DOT1 like histone lysine methyltransferase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 7:8,918,764...8,959,474
Ensembl chr 7:8,917,786...8,956,475 		JBrowse link
histone H3K9 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ash1l ASH1 like histone lysine methyltransferase enables ISO (PMID:22939622) RGD PMID:22939622 NCBI chr 2:174,346,267...174,483,057
Ensembl chr 2:174,346,150...174,483,055 		JBrowse link
G Ehmt1 euchromatic histone lysine methyltransferase 1 enables ISO
IBA		 (PMID:12004135)
GO_REF:0000033
(PMID:15774718), (PMID:18818694)		 RGD
GO_Central		 PMID:12004135 PMID:15774718 PMID:18818694 GO_REF:0000033 NCBI chr 3:7,580,680...7,729,046
Ensembl chr 3:7,580,683...7,729,007 		JBrowse link
G Ehmt2 euchromatic histone lysine methyltransferase 2 enables ISO
IBA		 MGI:3718790 (PMID:15774718), (PMID:15788566), (PMID:17212651), (PMID:17599069), (PMID:17707230), (PMID:18818694), (PMID:19144645)
GO_REF:0000033		 RGD
GO_Central		 PMID:15774718 PMID:15788566 PMID:17212651 PMID:17599069 PMID:17707230 More... GO_REF:0000033 NCBI chr20:3,919,623...3,936,751
Ensembl chr20:3,919,624...3,941,547 		JBrowse link
G ENSRNOG00000063631 enables IEA GO_REF:0000117 UniProt GO_REF:0000117 Ensembl chr  X:141,794,027...141,795,524 JBrowse link
G LOC120093070 PHD finger protein 11-like enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:33,526,380...33,549,382
Ensembl chr15:33,453,952...33,606,470 		JBrowse link
G LOC120093163 PHD finger protein 11-like enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr15:33,453,948...33,475,669
Ensembl chr15:33,453,952...33,606,470 		JBrowse link
G Mecom MDS1 and EVI1 complex locus enables ISO (PMID:22939622) RGD PMID:22939622 NCBI chr 2:112,909,353...113,464,583
Ensembl chr 2:112,909,321...113,464,590 		JBrowse link
G Prdm16 PR/SET domain 16 enables ISO (PMID:22939622) RGD PMID:22939622 NCBI chr 5:164,879,864...165,203,986
Ensembl chr 5:164,880,587...165,203,601 		JBrowse link
G Prdm8 PR/SET domain 8 enables ISO (PMID:19646955) RGD PMID:19646955 NCBI chr14:11,403,202...11,424,059
Ensembl chr14:11,404,407...11,410,993 		JBrowse link
G Setd5 SET domain containing 5 enables ISO (PMID:22939622) RGD PMID:22939622 NCBI chr 4:146,217,172...146,294,896
Ensembl chr 4:146,217,180...146,294,894 		JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 enables ISO
IBA		 (PMID:14536086)
(PMID:11791185), (PMID:22079090), (PMID:22939622)
GO_REF:0000033		 RGD
GO_Central		 PMID:11791185 PMID:14536086 PMID:22079090 PMID:22939622 GO_REF:0000033 NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506 		JBrowse link
G Setdb2 SET domain bifurcated histone lysine methyltransferase 2 enables ISO
IBA		 (PMID:20404330)
GO_REF:0000033		 RGD
GO_Central		 PMID:20404330 GO_REF:0000033 NCBI chr15:33,553,657...33,606,586
Ensembl chr15:33,453,952...33,606,470 		JBrowse link
G Setmar SET domain and mariner transposase fusion gene enables IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr 4:141,046,058...141,058,183
Ensembl chr 4:141,046,069...141,058,197 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase enables ISO
IBA		 (PMID:10949293), (PMID:18004385), (PMID:18485871), (PMID:23509280)
MGI:1890396|MGI:2445449 (PMID:10949293), (PMID:15788566), (PMID:18004385), (PMID:23509280), (PMID:23695662), (PMID:24413057)
GO_REF:0000033		 RGD
GO_Central		 PMID:10949293 PMID:15788566 PMID:18004385 PMID:18485871 PMID:23509280 More... GO_REF:0000033 NCBI chr  X:14,421,028...14,433,993
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 enables ISO (PMID:10949293), (PMID:18004385), (PMID:18485871), (PMID:23509280)
MGI:1890396|MGI:2445449 (PMID:10949293), (PMID:15788566), (PMID:18004385), (PMID:23509280), (PMID:23695662), (PMID:24413057)		 RGD PMID:10949293 PMID:15788566 PMID:18004385 PMID:18485871 PMID:23509280 More... NCBI chr  X:141,792,589...141,795,257 JBrowse link
G Suv39h2 SUV39H2 histone lysine methyltransferase enables ISO
IBA		 (PMID:10949293)
MGI:1099440 (PMID:15788566)
GO_REF:0000033		 RGD
GO_Central		 PMID:10949293 PMID:15788566 GO_REF:0000033 NCBI chr17:74,756,290...74,775,332
Ensembl chr17:74,756,306...74,775,332 		JBrowse link
histone H3K9 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prdm2 PR/SET domain 2 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 5:155,421,066...155,531,884
Ensembl chr 5:155,422,134...155,531,825 		JBrowse link
G Prdm9 PR/SET domain 9 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652 		JBrowse link
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 enables ISO (PMID:14536086) RGD PMID:14536086 NCBI chr 2:182,898,738...182,930,283
Ensembl chr 2:182,898,738...182,930,506 		JBrowse link
G Suv39h1 SUV39H1 histone lysine methyltransferase enables ISO (PMID:30111536) RGD PMID:30111536 NCBI chr  X:14,421,028...14,433,993
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 enables ISO (PMID:30111536) RGD PMID:30111536 NCBI chr  X:141,792,589...141,795,257 JBrowse link
G Suv39h2 SUV39H2 histone lysine methyltransferase enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr17:74,756,290...74,775,332
Ensembl chr17:74,756,306...74,775,332 		JBrowse link
histone H3K9me2 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Suv39h1 SUV39H1 histone lysine methyltransferase enables ISO MGI:1890396 (PMID:23451023) RGD PMID:23451023 NCBI chr  X:14,421,028...14,433,993
Ensembl chr  X:14,421,109...14,433,982 		JBrowse link
G Suv39h1-ps1 SUV39H1 histone lysine methyltransferase, pseudogene 1 enables ISO MGI:1890396 (PMID:23451023) RGD PMID:23451023 NCBI chr  X:141,792,589...141,795,257 JBrowse link
G Suv39h2 SUV39H2 histone lysine methyltransferase enables ISO MGI:1099440 (PMID:23451023) RGD PMID:23451023 NCBI chr17:74,756,290...74,775,332
Ensembl chr17:74,756,306...74,775,332 		JBrowse link
histone H4K12 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carm1 coactivator-associated arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 8:20,097,262...20,141,950
Ensembl chr 8:20,097,254...20,147,689 		JBrowse link
G N6amt1 N-6 adenine-specific DNA methyltransferase 1 enables ISO (PMID:31061526) RGD PMID:31061526 NCBI chr11:26,584,750...26,597,790
Ensembl chr11:26,584,724...26,608,248 		JBrowse link
G Ndufaf7 NADH:ubiquinone oxidoreductase complex assembly factor 7 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 6:16,108,630...16,119,810
Ensembl chr 6:16,103,003...16,119,810 		JBrowse link
G Prmt1 protein arginine methyltransferase 1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345 		JBrowse link
G Prmt5 protein arginine methyltransferase 5 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr15:27,968,893...27,978,291
Ensembl chr15:27,968,910...27,978,296 		JBrowse link
histone H4K20 methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07010705.1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr 2:142,289,467...142,290,623 JBrowse link
G AABR07033047.1 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 Ensembl chr11:3,479,411...3,480,543 JBrowse link
G ENSRNOG00000067141 enables IEA GO_REF:0000002 InterPro GO_REF:0000002 Ensembl chr10:31,086,733...31,087,921 JBrowse link
G Kmt5a lysine methyltransferase 5A enables ISO
IBA		 (PMID:27338793)
GO_REF:0000033		 RGD
GO_Central		 PMID:27338793 GO_REF:0000033 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711 		JBrowse link
G Kmt5al2 lysine methyltransferase 5A like 2 enables IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:92,178,344...92,180,517
Ensembl chr  X:92,178,016...92,179,731 		JBrowse link
G Kmt5b lysine methyltransferase 5B enables ISS
ISO
IBA
IEA		 GO_REF:0000024
(PMID:15145825), (PMID:24049080)
GO_REF:0000033
GO_REF:0000117
(PMID:24396869), (PMID:28114273)		 UniProt
RGD
GO_Central		 PMID:15145825 PMID:24049080 PMID:24396869 PMID:28114273 GO_REF:0000024 GO_REF:0000033 GO_REF:0000117 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819 		JBrowse link
G Kmt5c lysine methyltransferase 5C enables ISO
IBA
ISS		 (PMID:24049080), (PMID:24396869), (PMID:28114273)
(PMID:15145825), (PMID:25335925)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:15145825 PMID:24049080 PMID:24396869 PMID:25335925 PMID:28114273 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145 		JBrowse link
G Nsd1 nuclear receptor binding SET domain protein 1 enables ISO (PMID:12805229) RGD PMID:12805229 NCBI chr17:9,311,963...9,426,373
Ensembl chr17:9,315,237...9,425,358 		JBrowse link
G Setd4 SET domain containing 4 enables ISO (PMID:31308046) RGD PMID:31308046 NCBI chr11:32,829,509...32,859,162
Ensembl chr11:32,838,063...32,858,243 		JBrowse link
G Smyd5 SMYD family member 5 enables IBA
ISO		 GO_REF:0000033
(PMID:22921934), (PMID:28250819)		 GO_Central
RGD		 PMID:22921934 PMID:28250819 GO_REF:0000033 NCBI chr 4:117,969,615...117,984,082
Ensembl chr 4:117,969,626...117,984,347 		JBrowse link
histone H4K20 monomethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07010705.1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 Ensembl chr 2:142,289,467...142,290,623 JBrowse link
G AABR07033047.1 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 Ensembl chr11:3,479,411...3,480,543 JBrowse link
G Kmt5a lysine methyltransferase 5A enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr12:32,139,353...32,167,777
Ensembl chr12:32,139,178...32,162,711 		JBrowse link
G Kmt5al2 lysine methyltransferase 5A like 2 enables IEA GO_REF:0000003 UniProt GO_REF:0000003 NCBI chr  X:92,178,344...92,180,517
Ensembl chr  X:92,178,016...92,179,731 		JBrowse link
G Kmt5b lysine methyltransferase 5B enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819 		JBrowse link
G Kmt5c lysine methyltransferase 5C enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145 		JBrowse link
G Prdm9 PR/SET domain 9 enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652 		JBrowse link
histone H4K20 trimethyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ttll12 tubulin tyrosine ligase like 12 NOT|enables ISO (PMID:23251473) RGD PMID:23251473 NCBI chr 7:114,731,890...114,751,237
Ensembl chr 7:114,731,892...114,751,356 		JBrowse link
histone H4K20me methyltransferase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kmt5b lysine methyltransferase 5B enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:201,000,444...201,049,819
Ensembl chr 1:201,000,444...201,049,819 		JBrowse link
G Kmt5c lysine methyltransferase 5C enables IEA GO_REF:0000003
GO_REF:0000116		 UniProt
RHEA		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:69,099,531...69,107,145
Ensembl chr 1:69,099,539...69,107,145 		JBrowse link
G Prdm9 PR/SET domain 9 enables IEA GO_REF:0000116
GO_REF:0000003		 RHEA
UniProt		 GO_REF:0000003 GO_REF:0000116 NCBI chr 1:56,505,579...56,525,726
Ensembl chr 1:56,505,579...56,525,652 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20627
    catalytic activity 6029
      catalytic activity, acting on a protein 2508
        protein methyltransferase activity 104
          protein-lysine N-methyltransferase activity 69
            [cytochrome c]-lysine N-methyltransferase activity 0
            calmodulin-lysine N-methyltransferase activity 1
            histone H3K27 methyltransferase activity + 6
            histone H3K36 methyltransferase activity + 13
            histone H3K37 methyltransferase activity 4
            histone H3K4 methyltransferase activity + 17
            histone H3K56 methyltransferase activity 5
            histone H3K79 methyltransferase activity + 1
            histone H3K9 methyltransferase activity + 18
            histone H4K12 methyltransferase activity 5
            histone H4K20 methyltransferase activity + 12
Path 2
Term Annotations click to browse term
  molecular_function 20627
    catalytic activity 6029
      transferase activity 2396
        transferase activity, transferring one-carbon groups 213
          methyltransferase activity 203
            S-adenosylmethionine-dependent methyltransferase activity 169
              lysine N-methyltransferase activity 69
                protein-lysine N-methyltransferase activity 69
                  [cytochrome c]-lysine N-methyltransferase activity 0
                  calmodulin-lysine N-methyltransferase activity 1
                  histone H3K27 methyltransferase activity + 6
                  histone H3K36 methyltransferase activity + 13
                  histone H3K37 methyltransferase activity 4
                  histone H3K4 methyltransferase activity + 17
                  histone H3K56 methyltransferase activity 5
                  histone H3K79 methyltransferase activity + 1
                  histone H3K9 methyltransferase activity + 18
                  histone H4K12 methyltransferase activity 5
                  histone H4K20 methyltransferase activity + 12
paths to the root